Acute Immunological Effects of Exercise in Cancer Patients
ACTIVE
ACTIVE- Acute Effects of a Single Physical Exercise Intervention on Immune Cells and Inflammation in Cancer Patients and a Healthy Comparison Group
1 other identifier
interventional
60
1 country
1
Brief Summary
The aim of the study is to evaluate and compare immune response to a single exercise intervention in cancer patients and healthy age-maged individuals.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_2 cancer
Started Dec 2022
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 13, 2022
CompletedFirst Posted
Study publicly available on registry
December 19, 2022
CompletedStudy Start
First participant enrolled
December 19, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2025
CompletedDecember 6, 2024
December 1, 2024
1.6 years
November 13, 2022
December 3, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Number of Natural Killer Cells
NK cells, subgroups and innate lymphoid cells
Change from pre Intervention to immediately after intervention and 1 hour post intervention
Secondary Outcomes (3)
Subjective Quality of Life
Once after intervention
Fatigue
Once after intervention
Nutritional status
Once after intervention
Study Arms (2)
Cancer patients
EXPERIMENTALSingle exercise intervention following a HIIT protocol, duration \~20 mins
Healthy adults
ACTIVE COMPARATORSingle exercise intervention following a HIIT protocol, duration \~20 mins
Interventions
Endurance training adapted to age, resting heart rate
Eligibility Criteria
You may qualify if:
- Adolescents and young adults \>14 years of age
- undergoing acute cancer treatment (chemotherapy)
- signed informed consent
You may not qualify if:
- Inability to follow and implement test instructions
- medical contraindication to HIIT on cycle ergometer
- chemotherapeutic treatment 48 h prior
- Hb \<8g/dl; platelets \< 20,000/ul.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Essen
Essen, North Rhine-Westphalia, 45147, Germany
Related Publications (1)
Deppe I, Beller R, Kiehl F, Lazzari N, Bennstein SB, Reinhardt D, Dirksen U, Gotte M. The impact of a single HIIT intervention on the mobilization of NK cells and ILCs in adolescents and young adults (AYA) undergoing cancer treatment: an interventional controlled trial. BMC Cancer. 2025 Apr 14;25(1):689. doi: 10.1186/s12885-025-14058-3.
PMID: 40229731DERIVED
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Miriam Götte, Dr.
University Hospital, Essen
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
November 13, 2022
First Posted
December 19, 2022
Study Start
December 19, 2022
Primary Completion
July 31, 2024
Study Completion
July 1, 2025
Last Updated
December 6, 2024
Record last verified: 2024-12
Data Sharing
- IPD Sharing
- Will not share