Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Pulmonary Mechanics

NCT06118489 | Completed

• 1 other identifier: HamidiyeKAEK-98172
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The bronchodilator effects of volatile anesthetics have been the subject of many clinical studies. It is known that all volatile anesthetics, especially halothane, have similar effects. Sevoflurane has been shown to reduce airway resistance more than halothane and isoflurane. Desflurane is difficult to use as an induction agent due to its harsh and extremely pungent odor and airway irritating effect. However, it has been shown that the risk of cough, respiratory arrest and laryngospasm is no different from sevoflurane when administered after intravenous induction. Although it irritates the airway, it is thought to have a bronchodilation effect as it stimulates the sympathetic system. In spinal surgeries, prone position is required to access the operating field. When the patient is placed in the prone position, pulmonary physiology are affected. In the prone position, V/Q mismatch decreases and arterial oxygenation increases. However, lung compliance decreases and the peak inspiratory pressure required to reach the required tidal volume increases. The main purpose of this study is the effect of volatile agents on lung mechanics and oxygenisation in the prone position.

Conditions

Oxygenation; Spinal Surgery; Sevoflurane; Desflurane

Outcome Measures

Primary Outcomes (1)

• compliance

  pulmonary compliance before, during and after prone position

  2 hour

Study Arms (2)

sevoflurane

desflurane

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

ASA 1-2 patients between the ages of 18 and 65 who are scheduled for spinal surgery will be included in the study.

You may qualify if:

• years old
• ASA1-2
• Patients planned to undergo spinal surgery

You may not qualify if:

• Lung disease
• BMI 35 and above
• Smokers
• Those under the age of 18 and over the age of 65
• Hepatorenal disease
• Reynaud's disease
• Burger disease
• Hypotensive patient
• Neuromuscular disease
• Those who have had thoracic surgery before
• Those with bad Allen test results

Sponsors & Collaborators

• Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey: lead

Study Sites (1)

Yadigar Yılmaz

Istanbul, 34230, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: October 31, 2023
• First Posted: November 7, 2023
• Study Start: December 1, 2023
• Primary Completion: February 1, 2024
• Study Completion: February 1, 2024
• Last Updated: June 10, 2025

Record last verified: 2025-06

Locations

TU (1)