To Compare the Consumption of Sevoflurane and Desflurane in Low Flow Anaesthesia

NCT06602947 | Completed

• 1 other identifier: Res/SCM/23/2017/53
• Study Type: observational
• Target: 564
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to compare sevoflurane and Desflurane consumption in low-flow anaesthesia using the ASA (American Society of Anaesthesiology). Environmental Sustainability Committee recommendations. The patients aged 20-65 years, ASA I and II undergoing surgery under general anaesthesia were included in the study. Question: Can we reduce our carbon footprint of desflurane and sevoflurane using low-flow anaesthesia, according to the recommendations of the ASA Environment Sustainability Committee? PRIMARY To compare the mac hour consumption of sevoflurane and desflurane anaesthetic agents under low flow (one litre/min) conditions To calculate the carbon footprint of sevoflurane and desflurane in the study cases. SECONDARY To test whether a significant generation of carbon monoxide occurs due to the interaction of sevoflurane/desflurane with soda lime in the closed circuit Groups 1) low-flow sevoflurane (LFS)- 1 L/min gas flow 2) low- flow desflurane (LFD)- 1 L/min gas flow Anaesthesia will be administered according to the recommendations of the ASA Environment Sustainability Committee. Three strategies to reduce the fresh gas flow and environmental contamination are

1. 1.Induction: Set the Vaporizer to Deliver a Concentration Greater than Intended
2. 2.Intubation: Turn Off the Fresh Gas Flow, Not the Vaporizer.
3. 3.Maintenance: Minimize Fresh Gas Flow During Maintenance.

Conditions

Sevoflurane; Desflurane

Keywords

Low flow anesthesia; carbon footprint

Outcome Measures

Primary Outcomes (2)

• To compare the MAC hour consumption of sevoflurane under low flow conditions. To compare the mac hour consumption of sevoflurane and desflurane anasthetic agents under low flow (one litre/min) conditi

  To compare the mac hour consumption of sevoflurane anasthetic agents under low flow (one litre/min) conditions To calculate the carbon foot print of sevoflurane and desflurane in the low flow anaesthesia being used in this study

  Duration of surgery 4hours,4-6 hours, more than 6hours

• To calculate the carbon foot print of sevoflurane and desflurane in low flow anaesthesia

  Carbon foot print calculation according to the formula

  Duration of surgery

Secondary Outcomes (1)

• To test whether significant generation of carbon monoxide occurs due to interaction of sevoflurane / desflurane with sodalime in the closed circuit.

  end of surgery

Study Arms (2)

low-flow sevoflurane (LFS)

Anaesthesia will be administered according to the recommendations of ASA Enviornment Sustainability Committee. Three strategies to reduce the fresh gas flow and enviornmental contamination are 1. Induction: Set the Vaporizer to Deliver a Concentration Greater than Intended 2. Intubation: Turn Off the Fresh Gas Flow, Not the Vaporizer. 3. Maintanance: Minimize Fresh Gas Flow During Maintenance.

Other: Low flow anaesthesia using ASA enviormental sustanibility commitee recomendation

low- flow desflurane (LFD)

Anaesthesia will be administered according to the recommendations of ASA Enviornment Sustainability Committee. Three strategies to reduce the fresh gas flow and enviornmental contamination are 1. Induction: Set the Vaporizer to Deliver a Concentration Greater than Intended 2. Intubation: Turn Off the Fresh Gas Flow, Not the Vaporizer. 3. Maintanance: Minimize Fresh Gas Flow During Maintenance.

Other: Low flow anaesthesia using ASA enviormental sustanibility commitee recomendation

Interventions

Low flow anaesthesia using ASA enviormental sustanibility commitee recomendation OTHER

1. Induction: Set the Vaporizer to Deliver a Concentration Greater than Intended 2. Intubation: Turn Off the Fresh Gas Flow, Not the Vaporizer. 3. Maintanance: Minimize Fresh Gas Flow During Maintenance.

low- flow desflurane (LFD); low-flow sevoflurane (LFS)

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

564 patients aged 20-65 and ASA status I-II scheduled for procedures longer than three hours duration at RGCI\&RC from 2017-2018 will be included in this study

You may qualify if:

• Patients with American Society of Anesthesiologists grade (ASA) I \& II.
• Patients with age 20-65 years.

You may not qualify if:

• Contraindications to inhalation agents.
• Liver dysfunction.
• Chronic alcoholism.
• Chronic smokers.

Sponsors & Collaborators

• Rajiv Gandhi Cancer Institute & Research Center, India: lead

Study Sites (1)

RGCI& RC

Delhi, 110085, India

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Anaesthesia

Study Record Dates

• First Submitted: September 19, 2021
• First Posted: September 19, 2024
• Study Start: February 16, 2018
• Primary Completion: September 16, 2021
• Study Completion: December 1, 2021
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)