The Effect of Anthropometrics on Desflurane Rise Time

NCT06026033 | Completed DMC

• 1 other identifier: 2022/11
• Study Type: observational
• Target: 361
• Locations: 1 country
• Sites: 1

Brief Summary

Desflurane is increasingly used in general anesthesia. Its pharmacokinetic properties are known and its distribution is easily modeled. Yet these models fail in practice. In order to increase accuracy, any model should include cardiac output, alveolar ventilation and alveolar dead space, all of which are either hard to measure or impractical, at least. A previous study performed by the same investigator showed that time to target endtidal concentration of sevoflurane is prolonged with increased cardiac output, but only if the patient has increased muscle mass. Although desflurane has lower muscle and fat solubility, our observations suggest a similar prolongation in case of increased muscle mass. The investigators aim to investigate if patient characteristics such as gender, age, height, weight, body type prolongs time to reach target endtidal desflurane concentration in low flow anesthesia.

Conditions

Desflurane; Anesthesia, General

Keywords

Anesthetics, Inhalation; Anesthesia, General; Desflurane

Outcome Measures

Primary Outcomes (2)

• Rate of rise in expiratory desflurane concentration

  Correlation between the time required for the endtidal expiratory desflurane concentration to reach 8% and patient characteristics

  intraoperative

• Rate of rise in inspiratory desflurane concentration

  Correlation between the time required for the endtidal inspiratory desflurane concentration to reach 6% and patient characteristics

  intraoperative

Secondary Outcomes (2)

• Correlation between occurrence of hypertension and patient characteristics

  intraoperative

• Correlation between occurrence of tachycardia and patient characteristics

  intraoperative

Study Arms (1)

Patients scheduled for general anesthesia

Patients scheduled for elective general anesthesia will be included, if accepts and signs the informed consent. The inhalational anesthetic should be desflurane. No other inhalational agent should be used during the induction of anesthesia. The inspiratory and expiratory concentration of any inhalational agent should be zero before the induction of anesthesia.

Drug: Desflurane induction

Interventions

Desflurane induction DRUG

Following tracheal intubation, the fresh gas flow will be set to 1 liters/minute, desflurane vaporizer will be set to maximum.

Patients scheduled for general anesthesia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients, who are scheduled for elective general anesthesia. Maintenance of anesthesia with desflurane should be included in the routine anesthesia plan.

You may qualify if:

• age \> 18 years
• planned elective surgery
• planned inhalational anesthesia
• planned use of desflurane

You may not qualify if:

• emergency surgery
• use of other inhalational anesthetic agent (sevoflurane, isoflurane, nitrous oxide)
• disclosed or recognized pregnancy

Sponsors & Collaborators

• Recep Tayyip Erdogan University: lead

Study Sites (1)

Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation

Rize, 53100, Turkey (Türkiye)

Location

Related Publications (3)

• Weber J, Missbach C, Schmidt J, Wenzel C, Schumann S, Philip JH, Wirth S. Prediction of expiratory desflurane and sevoflurane concentrations in lung-healthy patients utilizing cardiac output and alveolar ventilation matched pharmacokinetic models: A comparative observational study. Medicine (Baltimore). 2021 Feb 12;100(6):e23570. doi: 10.1097/MD.0000000000023570.

  PMID: 33578509 RESULT

• Athiraman U, Ravishankar M, Jahagirdhar S. Performance of computer simulated inhalational anesthetic uptake model in comparison with real time isoflurane concentration. J Clin Monit Comput. 2016 Dec;30(6):791-796. doi: 10.1007/s10877-015-9776-6. Epub 2015 Sep 19.

  PMID: 26386708 RESULT

• Philip JH. Using screen-based simulation of inhaled anaesthetic delivery to improve patient care. Br J Anaesth. 2015 Dec;115 Suppl 2:ii89-94. doi: 10.1093/bja/aev370.

  PMID: 26658205 RESULT

MeSH Terms

Conditions

Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Başar Erdivanlı, Assoc. Prof.

  Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation

  STUDY DIRECTOR

• Alihan Madran, M.D.

  Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc Prof

Study Record Dates

• First Submitted: March 31, 2023
• First Posted: September 6, 2023
• Study Start: February 1, 2022
• Primary Completion: August 30, 2023
• Study Completion: September 1, 2023
• Last Updated: December 22, 2023

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)