Sevoflurane Versus Propofol: Effect on Stress Response

NCT06386965 | Completed

• 1 other identifier: 010.99/15
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Stress is defined as hormonal and metabolic changes in the biological system that follow any injury. The stress response occurs as a general systemic response to injury and includes a wide range of endocrinological, immunological and hematological effects. The level of stress in the surgical process can affect not only the patients outcome but also the overall health system. The two main agents used in maintenance for general anesthesia are inhalation and intravenous anesthetics. Both inhalation anesthesia and TIVA (Total Intravenous Anesthesia) approaches provide general anesthesia suitable for surgical operations. However, the mechanisms of action of these two methods differ and are not fully understood. The aim of investigators' for this study was to investigate the effect of different anesthetic agents on stress inflammatory response in the preoperative, peroperative and postoperative periods.

Conditions

Propofol; Sevoflurane; Inflammatory Response

Keywords

propofol; sevoflurane; inflammatory response

Outcome Measures

Primary Outcomes (1)

• compare inflammatory markers with sevolurane and propofol : glucose, WBC, procalcitonin, CRP, erytrocyte sedimentation rate, ferritin, pre albumin, albumin,tranferrin

  The primary aim of investigators' for this study was to compare the effect of different anesthetic agents on stress inflammatory response in the preoperative, peroperative and postoperative periods.

  preoperative, intraoperative, postoperative 12-24 h (an average of 3 months)

Study Arms (2)

propofol

General anesthesia will maintain with propofol in this group.

Other: taking blood sample

sevoflurane

General anesthesia will maintain with sevoflurane in this group.

Other: taking blood sample

Interventions

taking blood sample OTHER

A blood sample will be taken from the patients for 3 times to evaluate the stress inflammatory markers.

propofol; sevoflurane

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Between April and June 2023, ASA I-II, 18-65 years old 40 patients with single level lumbar disc herniation who underwent elective surgery in the neurosurgery operating room were planned to participate.

You may qualify if:

• Extruded disc
• Motor deficit
• L4-5, L5-S1 levels disc herniation
• years
• ASA I-II

You may not qualify if:

• Recurrence disc operation
• Narrow channel
• Trauma
• Infection
• Endocrine disease

Sponsors & Collaborators

• Dr. Lutfi Kirdar Kartal Training and Research Hospital: lead

Study Sites (1)

University of Health Science, Kartal Dr Lutfi Kırdar Training and Researh Hospital

Istanbul, Turkey (Türkiye)

Location

Related Publications (1)

• Yediyildiz MB, Durmus I, Ak HY, Taskin K, Ceylan MAD, Yuce Y, Cevik B, Aydogmus E. Comparison of inhalation and total intravenous anesthesia on inflammatory markers in microdiscectomy: a double-blind study. BMC Anesthesiol. 2025 May 10;25(1):238. doi: 10.1186/s12871-025-03119-6.

  PMID: 40348954 DERIVED

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology Specialist, MD

Study Record Dates

• First Submitted: April 18, 2024
• First Posted: April 26, 2024
• Study Start: May 23, 2024
• Primary Completion: June 5, 2024
• Study Completion: June 5, 2024
• Last Updated: August 9, 2024

Record last verified: 2024-08

Locations

TU (1)