The Relationship of Sevoflurane Consumption With Metabolic Age

NCT06018597 | Completed FDA Drug

• 1 other identifier: Inonu 2022/92
• Study Type: observational
• Target: 79
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this clinical study is to determine the consumption of sevoflurane, which is one of the inhalation anesthetics, with metabolic age and basal metabolic rate. The basal metabolic rates and metabolic ages of the patients who will be given sevoflurane- maintained general anesthesia were measured preoperatively. The relationship between the amount of sevoflurane consumption and the measured data of the patients in the postoperative period was examined.

Conditions

Sevoflurane

Keywords

Sevoflurane Consumption, Metabolic Age, Tanita

Outcome Measures

Primary Outcomes (1)

• consumption of sevoflurane

  Reducing patients' consumption of sevoflurane according to metabolic law

  patients during surgery

Study Arms (3)

percent age difference < -6.6%

The percentage age difference in the negative direction represents patients whose metabolic age is greater than their chronological age. When we analyze the ROC analysis in the negative direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percentage age difference is -6,6%. This group refers to those whose percentage age difference is less than -6.6%

Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL

percent age difference -6.6% to 11.7% those between

When we analyze the ROC analysis in the negative direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percentage age difference is -6,6%. When we analyze the ROC analysis in the positive direction, the cut-off value of the percent age difference is 11.7%. This group refers to those whose percentage age difference between -6.6% and 11.7%

Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL

percent age difference > 11.7%

the percent age difference in the positive direction represents patients whose metabolic age is less than their chronological age. When we analyze the ROC analysis in the positive direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percent age difference is 11.7%. This group refers to those whose percentage age difference is more than 11.7%

Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL

Interventions

Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL DRUG

No procedure was performed on the patient other than routine anesthesia management.We compared sevoflurane consumption amount in the patient undergoing general anesthesia with sevoflurane according to their metabolic age.

Also known as: No procedure was performed on the patient other than routine anesthesia management.

percent age difference -6.6% to 11.7% those between; percent age difference < -6.6%; percent age difference > 11.7%

Eligibility Criteria

• Age: 18 Years - 65 Years
• Gender Eligibility Details: ALL CENDER
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

18-65 AGE

You may qualify if:

• Between the ages of 18-65 who are scheduled for rhinoplasty or septoplasty with ASA I-II Cases lasting 1 to 3 hours
• Exclude Criteria:
• Patients at high risk of malignant hyperthermia, with a history of allergy to general anesthesia or any of the drugs to be used in the study, accepted as ASA III- ASA IV

Sponsors & Collaborators

• Inonu University: lead

Study Sites (1)

Inonu universitesi

Malatya, 44050, Turkey (Türkiye)

Location

Related Publications (2)

• St-Onge MP, Gallagher D. Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation? Nutrition. 2010 Feb;26(2):152-5. doi: 10.1016/j.nut.2009.07.004. Epub 2009 Dec 8.

  PMID: 20004080 BACKGROUND

• Ng JCM, Schooling CM. Effect of Basal Metabolic Rate on Cancer: A Mendelian Randomization Study. Front Genet. 2021 Sep 9;12:735541. doi: 10.3389/fgene.2021.735541. eCollection 2021.

  PMID: 34567085 BACKGROUND

MeSH Terms

Interventions

Fluid Therapy

Intervention Hierarchy (Ancestors)

Drug Therapy; Therapeutics

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: August 9, 2023
• First Posted: August 30, 2023
• Study Start: September 9, 2022
• Primary Completion: March 1, 2023
• Study Completion: March 3, 2023
• Last Updated: August 30, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)