NCT06080308

Brief Summary

Searching for new targets for the diagnosis and treatment of liver ischemia-reperfusion injury.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
270

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2023

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 6, 2023

Completed
4 days until next milestone

Study Start

First participant enrolled

October 10, 2023

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 12, 2023

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 20, 2023

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2024

Completed
Last Updated

April 10, 2024

Status Verified

April 1, 2024

Enrollment Period

2 months

First QC Date

October 6, 2023

Last Update Submit

April 8, 2024

Conditions

Liver Injury

Keywords

Hepatic ischemia; Reperfusion injury

Outcome Measures

Primary Outcomes (1)

  • Length of hospital stay

    Length of hospital stay

    7days

Interventions

No interventionOTHER

No intervention

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Criteria for liver ischemia-reperfusion injury patients: patients undergoing elective liver resection surgery with hepatic pedicle occlusion and reperfusion during the procedure.

You may qualify if:

  • Willingness to participate in the study and has signed an informed consent form. 2) Age ≥ 18 years and ≤ 70 years. 3) ASA classification ≤ III. 4) Criteria for liver ischemia-reperfusion injury patients: patients undergoing elective liver resection surgery with hepatic pedicle occlusion and reperfusion during the procedure.

You may not qualify if:

  • \) Patients with adverse events during surgery. 2) Patients in the end stage of disease with liver failure. 3) Liver tumor metastasis with concomitant severe heart failure or chronic renal insufficiency, etc. 4) Deemed unsuitable for participation in the study based on the judgment of the researchers.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

During the procedure, the remaining blood samples are checked for blood gas analysis, and then plasma is taken

MeSH Terms

Conditions

Reperfusion Injury

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesPostoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
phd

Study Record Dates

First Submitted

October 6, 2023

First Posted

October 12, 2023

Study Start

October 10, 2023

Primary Completion

December 20, 2023

Study Completion

September 30, 2024

Last Updated

April 10, 2024

Record last verified: 2024-04

Locations

CN(1)