Tissue Kallikrein Protect Against Ischemic Stroke

NCT06422572 | Completed

• 1 other identifier: TJ-IRB202303109
• Study Type: observational
• Target: 8,602
• Locations: 1 country
• Sites: 1

Brief Summary

The results of previous studies were used to assess the causal association between TK levels and stroke occurrence at 5 and 12 years of follow-up, respectively.

Conditions

Stroke, Ischemic

Keywords

Stroke

Outcome Measures

Primary Outcomes (1)

• Incidence of Stroke

  The primary outcome measure will be the occurrence of stroke during the 5-year follow-up period. Stroke events will be assessed and recorded based on predetermined diagnostic criteria, such as clinical symptoms, imaging findings, and/or medical records review. The data will be aggregated and reported as the total number of stroke cases observed in the study population.

  5 years

Study Arms (1)

Population without stroke

1. Control population in a case-controlled study of prior stroke ; 2. Control population in a case-controlled study of preexisting coronary heart disease; 3. Population in previous community cross-sectional studies .

Other: No Intervention

Interventions

No Intervention OTHER

No Intervention

Population without stroke

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

1. Control population in the previous stroke case-control study; 2. The CHD case-control population in the previous study; 3. The population in the community cross-sectional study of the previous study.

You may qualify if:

• \) Control population in the previous stroke case-control study;
• \) The CHD case-control population in the previous study;
• \) The population in the community cross-sectional study of the previous study.

You may not qualify if:

• Stroke patient

Sponsors & Collaborators

• Qin Zhang: lead
• National Natural Science Foundation of China: collaborator

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

Location

Biospecimen

Retention: NONE RETAINED

Part of the sample consisted of 1210 stroke controls and 905 coronary heart disease controls enrolled from December 2000 to November 2001 in the previous study. The other part comes from 6,487 cases of community population in Rizhao area from May to August 2010.

MeSH Terms

Conditions

Ischemic Stroke; Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• QIN Zhang, phd

  Tongji Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PROFESSOR

Study Record Dates

• First Submitted: May 7, 2024
• First Posted: May 21, 2024
• Study Start: May 1, 2023
• Primary Completion: December 30, 2023
• Study Completion: December 30, 2023
• Last Updated: May 21, 2024

Record last verified: 2023-03

Locations

CN (1)