NCT07101718

Brief Summary

This is a multi-center study to investigate the impact of fibrotic liver greafts in liver transplant recipient.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25,419

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2024

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2024

Completed
9 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 10, 2024

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

July 28, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

August 3, 2025

Completed
Last Updated

August 3, 2025

Status Verified

July 1, 2025

Enrollment Period

9 days

First QC Date

July 28, 2025

Last Update Submit

July 28, 2025

Conditions

Liver Transplant

Outcome Measures

Primary Outcomes (1)

  • Overall survival rates

    The overall survival of liver transplant recipients.

    January 2015 to December 2024

Secondary Outcomes (1)

  • Graft survival rates

    January 2015 to December 2024

Study Arms (3)

No fibrotic

Liver transplant recipient receiving no fibrotic liver grafts.

Other: No intervention

Mild fibrotic

Liver transplant recipient receiving mild fibrotic liver grafts.

Other: No intervention

Significant

Liver transplant recipient receiving significant fibrotic liver grafts.

Other: No intervention

Interventions

No interventionOTHER

No intervention

Mild fibroticNo fibroticSignificant

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

A total of 25419 patients underwent liver transplant were studied.

You may qualify if:

  • patients receiving liver transplantation during the period from March 2015 to March 2024

You may not qualify if:

  • recipients under 18 years old
  • re-transplantation cases
  • multiorgan transplant cases, reduced-size or split LT cases
  • lacking follow-up records or graft biopsy records

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Zhejiang University school of Medicine

Hangzhou, Zhejiang, 310006, China

Location

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

July 28, 2025

First Posted

August 3, 2025

Study Start

July 1, 2024

Primary Completion

July 10, 2024

Study Completion

December 31, 2024

Last Updated

August 3, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations

CN(1)