A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults

NCT05869526 | Completed

• 1 other identifier: FISHKRILL
• Study Type: interventional
• Target: 61
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.

Conditions

Sarcopenia

Keywords

muscle mass; strength; omega-3; ageing

Outcome Measures

Primary Outcomes (1)

• Change in knee extensor maximal isometric torque ( MVC)

  Knee extensor maximal isometric torque measured during a maximal voluntary contraction

  Change from baseline to 16 weeks

Secondary Outcomes (9)

• Change in fat mass

  Change from baseline to 16 weeks

• Change in lean mass

  Change from baseline to 16 weeks

• Blood sample

  Change from baseline to 16 weeks

• Change in Grip strength

  Change from baseline to 16 weeks

• Change in Muscle thickness

  Change from baseline to 16 weeks

Other Outcomes (20)

• Step Time (Sec)

  Change from baseline to 16 weeks

• Cycle Time (Sec)

  Change from baseline to 16 weeks

• Step Length (CM)

  Change from baseline to 16 weeks

Study Arms (3)

Fish oil

ACTIVE COMPARATOR

Fish oil 4 g/day

Dietary Supplement: Fish oil

Krill oil

ACTIVE COMPARATOR

Krill oil 4g/day

Dietary Supplement: Kril oil

Placebo

PLACEBO COMPARATOR

Vegetable oil 4g/day

Dietary Supplement: Vegetable oil

Interventions

Fish oil DIETARY_SUPPLEMENT

EPA rich fish oil

Fish oil

Kril oil DIETARY_SUPPLEMENT

Superba Krill Oil

Krill oil

Vegetable oil DIETARY_SUPPLEMENT

Mixed vegetable oil

Placebo

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Older adults (aged 60 years or older). BMI less than 30kg/m2

You may not qualify if:

• Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.

Sponsors & Collaborators

• University of Glasgow: lead

Study Sites (1)

Stuart Robert Gray

Glasgow, Scotland, United Kingdom

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Fish Oils; Plant Oils

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Oils; Lipids; Plant Preparations; Biological Products; Complex Mixtures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Supplements will be identical in look and taste
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: 1:1:1 basis

Study Record Dates

• First Submitted: May 11, 2023
• First Posted: May 22, 2023
• Study Start: May 1, 2023
• Primary Completion: February 1, 2024
• Study Completion: April 1, 2024
• Last Updated: March 30, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)