Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity

NCT05934760 | Unknown

• 1 other identifier: Mi-HIIT CMMP
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this interventional study is to learn about the role of mitochondrial function in healthy aging, and then go on and assess the role of a home-based exercise program on the changes seen. The main question\[s\] it aims to answer are:

• What alterations in skeletal muscle mitochondrial function are seen in healthy aging?
• Can a short-term exercise program alter these alterations seen? The older participants will be invited to take part in a home-based 4 week exercise intervention involving either:
• High intensity interval training
• Resistance based training (resistance bands will be provided) Researchers will compare the two exercise groups to see if it alters mitochondrial function.

Conditions

Aging; Sarcopenia

Keywords

Exercise; Mitochondrial function; Healthy Aging

Outcome Measures

Primary Outcomes (3)

• Mitochondrial activity across age

  Mitochondrial oxidative phosphorylation capacity changes seen across the age groups investigated Mitochondrial oxidative phosphorylation capacity will be measured according to oxygen consumption determined by the use of a high-definition respirometer. This will then be compared across ages and expressed as a ratio of maximal consumption.

  This will be compared across baseline assessment dates in all ages.

• Mitochondrial activity change with a short-term home-based exercise program in older participants

  The effect of either a resistance exercise-based and high-intensity interval training-based home-based training program on mitochondrial function in those over aged 60 Mitochondrial oxidative phosphorylation capacity will be measured according to oxygen consumption determined by the use of a high-definition respirometer. The changes seen throughout the treatment will then be expressed as a percentage in order to express the changes seen from the baseline.

  Assessed prior to and after the completion of a 4 week exercise program

• The altered response to training type

  The differing responses to either high intensity interval training or resistance based training Mitochondrial oxidative phosphorylation capacity will be measured according to oxygen consumption determined by the use of a high-definition respirometer. The changes caused by the training regimen will then be expressed as a percentage in order to express the changes seen from the baseline, and in order to allow comparison between training modality.

  4 weeks

Study Arms (2)

High intensity interval training (HIIT)

EXPERIMENTAL

Older participants (over 60) will be randomized to perform home-based unsupervised exercise, the HIIT group will perform the HIIT intervention 3 times a week, at home, unsupervised for 4 weeks. This will be supported by regular contact from a member of the research team to provide support and to encourage adherance. Our research group has conducted many similar exercise regimes of this intensity to subjects in the anticipated age-range without incident. Participants will be adviced to terminate exercise training immediately if experiencing: * Chest pain or tightness * Faintness * Sudden pallor * Loss of co-ordination * Confusion * Dizziness * Palpitations * Sudden breathlessness Should any participant experience these effects during any session, they will be advised to seek urgent medical attention and will be withdrawn from the exercise arm of the study for safety purposes.

Other: High intensity interval training (HIIT)

Resistance exercise training (RET)

EXPERIMENTAL

Older participants (over 60) will be randomized to perform home-based unsupervised exercise, the RET group will perform the RET intervention at home, 3 times a week unsupervised for 4 weeks.This will be supported by regular contact from a member of the research team to provide support and to encourage adherance. Our research group has conducted many similar exercise regimes of this intensity to subjects in the anticipated age-range without incident. Participants will be adviced to terminate exercise training immediately if experiencing: * Chest pain or tightness * Faintness * Sudden pallor * Loss of co-ordination * Confusion * Dizziness * Palpitations * Sudden breathlessness Should any participant experience these effects during any session, they will be advised to seek urgent medical attention and will be withdrawn from the exercise arm of the study for safety purposes.

Other: Resistance based training (RET)

Interventions

High intensity interval training (HIIT) OTHER

Each HIIT session last 15 minutes. Participants will be asked to measure their own heart rate during their rest periods and provided with an estimated max heart rate which they should be aiming to achieve within the final 2 exercises. Participants will be provided with a logbook to record the heart rate achieved in each exercise. The regimen will include: * 2 min warm-up: jogging on the spot * Each of the following exercises performed for 60seconds, interspaced by 90 seconds rest * Star jumps * Standing squats * On-the-spot sprints * Standing squats * Star jumps * 2 min cool-down: jogging on the spot

High intensity interval training (HIIT)

Resistance based training (RET) OTHER

Each RET session lasts an estimated 20minutes. Participants will be provided with a set of resistance bands to provide resistance to their workout, and a logbook to record the number of repetitions and band used. Each session will include: * 2 min warm-up jogging on the spot * 2 sets of 12-15 repetitions of: * Squats * Hip flexion * Hip extension * Hip abduction * Seated row * Bench press * Lateral raises * 2 min jogging on the spot cooldown. Each exercise will be separated by 1-minute rest, with participants encouraged to workout to mild fatigue on their final repetition in each set. If able to perform more than the allocated maximum of 15 repetitions prior to fatigue, then participants will be informed to increase the resistance by using a tougher resistance band.

Resistance exercise training (RET)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ● Healthy male or female aged over 18 years old able to give informed, written consent.

You may not qualify if:

• ● Current participation in a formal exercise regime
• Inability to use a static exercise bike
• A BMI \<18 or \>35 kg/m2
• Active cardiovascular disease:
• Uncontrolled hypertension (BP \> 160/100)
• Angina
• Heart failure (class III/IV)
• Significant arrhythmia
• Right to left cardiac shunt
• Recent cardiac event
• Taking beta-adrenergic blocking agents
• Cerebrovascular disease:
• Previous stroke
• Aneurysm (large vessel or intracranial)
• Epilepsy

Sponsors & Collaborators

• University of Nottingham: lead

Study Sites (1)

Graduate Entry Medical School, University of Nottingham, Royal Derby Hospital

Derby, Derbyshire, DE223NE, United Kingdom

Location

MeSH Terms

Conditions

Sarcopenia; Motor Activity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Due to the nature of exercise interventions, it is not possible to blind the participants or investigators.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 28, 2023
• First Posted: July 7, 2023
• Study Start: December 17, 2019
• Primary Completion: December 30, 2023
• Study Completion: March 30, 2024
• Last Updated: November 30, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)