Reducing Falls With Progressive Resistance Training for the Oldest Old Adults With Reduced Muscle Strength

NCT05691166 | Active Not Recruiting

• 1 other identifier: 2022/462261
• Study Type: interventional
• Target: 241
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the effects of 12 months of high-intensity progressive resistance training compared with a control group on fall-rate in older adults with reduced muscle strength.

Conditions

Sarcopenia; Aging

Outcome Measures

Primary Outcomes (1)

• Falls

  Relative risk for falls, fall rate per person years. Self-report.

  12 months

Secondary Outcomes (29)

• Falls

  6 months

• Falls

  6, 12, 24, and 36 months.

• Falls requiring medical attention

  6, 12, 24, 36 months

• Fall-related injuries

  6, 12, 24, 36 months

• Dynamic muscular strength

  6 and 12 months

Other Outcomes (5)

• Musculoskeletal pain

  6, 12, 24, 36 months

• Mortality

  0-12 and 0-36 months

• Cognitive function

  24 and 36 months

Study Arms (2)

Progressive resistance training

EXPERIMENTAL

Twice weekly high-intensity progressive resistance training for 12 months

Behavioral: High-intensity progressive resistance training

Control

ACTIVE COMPARATOR

Participants randomised to the control group receive a booklet containing Norway's current recommendations for physical activity for older adults. These recommendations mean ≥150 minutes of moderate-intensity or ≥75 minutes of vigorous-intensity physical activity per week and two to three weekly balance and resistance training sessions. The booklet also includes pictures and instructions for seven exercises to help prevent falls.

Other: Written physical activity guidance

Interventions

High-intensity progressive resistance training BEHAVIORAL

Twice-weekly high-intensity progressive resistance training for 12 months, delivered at community-based fitness centres. Both weekly sessions are supervised during the first 6 months; from month 6 onward, one session per week may be completed without direct supervision, provided at least one session per week remains supervised.

Progressive resistance training

Written physical activity guidance OTHER

Participants receive a booklet containing Norway's current physical activity recommendations for older adults, including instructions for seven exercises intended to reduce fall risk.

Control

Eligibility Criteria

• Age: 80 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Aged 80 years or older
• Low muscular strength (grip strength: \<41.6 kg for males and \<23.4 kg for females \[from 18.09.2024\] or chair stand \>15 seconds)
• Community-dwelling incl. independent senior housing
• Ambulatory without supervision or physical assistance from another person. Assistive devices such as canes/crutches/walkers allowed.
• Able to see and hear sufficiently to undertake assessments and partake in the planned exercise training.

You may not qualify if:

• Pre-existing diagnosis of dementia
• Moderate or severe cognitive impairment (score \<18 on the Mini-Mental State Examination)
• Living in institutional care
• Non-ambulatory or requiring person or wheelchair to assist when walking
• Degenerative neurological and neuromuscular disease/disorder significantly influencing gait and mobility (e.g. amyotrophic lateral sclerosis \[ALS\] and Parkinson's disease).
• Amputation (other than toes)
• Contraindications to resistance training
• Unstable fracture
• Inability to comply with study requirements
• Currently undertaking progressive resistance training

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead

Study Sites (1)

Department of Circulation and Medical Imaging

Trondheim, 7491, Norway

Location

Related Publications (1)

• Svinoy OE, Hilde G, Bergland A, Strand BH. Reference values for Jamar+ digital dynamometer hand grip strength in healthy adults and in adults with non-communicable diseases or osteoarthritis: the Norwegian Tromso study 2015-2016. Eur J Ageing. 2023 Nov 24;20(1):44. doi: 10.1007/s10433-023-00791-w.

  PMID: 37999814 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Jonathan Berg, PhD

  Norwegian University of Science and Technology

  PRINCIPAL INVESTIGATOR

• Øivind Rognmo, PhD

  Norwegian University of Science and Technology

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2022
• First Posted: January 19, 2023
• Study Start: March 30, 2023
• Primary Completion: September 29, 2026
• Study Completion (Estimated): September 29, 2028
• Last Updated: October 2, 2026

Record last verified: 2026-09

Locations

NO (1)