Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults

NCT04015479 | Completed

• 1 other identifier: 19-249
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in older adult men and women.

Conditions

Aging; Sarcopenia

Keywords

muscle protein synthesis; resistance training; protein supplementation; skeletal muscle physiology; inflammatory cytokines; fecal microbiome; plant protein

Outcome Measures

Primary Outcomes (2)

• Change in acute myofibrillar protein synthesis rates

  Change in right leg vastus lateralis myofibrillar protein synthesis rates using the integrated deuterium oxide technique from biopsies immediately before and 24 hours after resistance exercise

  24 hours

• Change in mid-thigh skeletal muscle area and quality

  peripheral quantitative computed tomography (pQCT) cross-sectional image of mid-right thigh assessed for total muscle cross-sectional area, subcutaneous adipose tissue area, total intra- and inter-muscular adipose tissue area and overall muscle density

  0-10 weeks

Secondary Outcomes (5)

• Change in whole-body and appendicular body composition

  0-10 weeks

• Change in Type I and II Muscle Fiber Cross-Sectional Area

  0-10 weeks

• Change in leg extensor isokinetic dynamometry

  0-10 weeks

• Change in inflammatory biomarkers

  0-10 weeks

• Change in fecal microbiome composition

  0-10 weeks

Study Arms (2)

Immediate Intervention Group

EXPERIMENTAL

Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder (72g/day) will be provided for daily consumption during the study period

Dietary Supplement: Peanut Protein Powder; Behavioral: Full body resistance training

Wait-list Control Group

ACTIVE COMPARATOR

Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder will be provided after the study period

Behavioral: Full body resistance training

Interventions

Peanut Protein Powder DIETARY_SUPPLEMENT

Peanut protein powder will be provided to participants who will be instructed to consume 72g daily, mixed with water

Immediate Intervention Group

Full body resistance training BEHAVIORAL

Participants will undergo supervised resistance training two times per week (5 exercises, 3 sets of 8-12 repetitions per set)

Immediate Intervention Group; Wait-list Control Group

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• body mass index (body mass/height squared) less than 35 kg/m2
• resting blood pressure averaging less than 140/90 mmHg (with or without medication)

You may not qualify if:

• known peanut allergy
• actively participating in resistance training for more than 2 days/week
• any known overt cardiovascular or metabolic disease
• metal implants that will interfere with x-ray procedures
• medically necessary radiation exposure in the last six months (except dental x-ray)
• any medical condition that would contradict participating in an exercise program, giving blood or donating a skeletal muscle biopsy (i.e. blood clotting disorder or taking blood thinners)

Sponsors & Collaborators

• Auburn University: lead
• Edward Via Virginia College of Osteopathic Medicine: collaborator
• The Peanut Institute: collaborator

Study Sites (1)

Auburn University

Auburn, Alabama, 36849, United States

Location

Related Publications (1)

• Lamb DA, Moore JH, Smith MA, Vann CG, Osburn SC, Ruple BA, Fox CD, Smith KS, Altonji OM, Power ZM, Cerovsky AE, Ross CO, Cao AT, Goodlett MD, Huggins KW, Fruge AD, Young KC, Roberts MD. The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals. J Int Soc Sports Nutr. 2020 Dec 14;17(1):66. doi: 10.1186/s12970-020-00397-y.

  PMID: 33317565 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Michael Roberts, PhD

  Auburn University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: PI and Co-Is will be blind to participant randomization. One study staff member will be responsible for administering the supplements to participants per randomization
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Intervention group will receive the supplement during the study period and the wait-listed control group will receive the supplement after the study period. Both groups will participate in resistance training during the 10 week period

Study Record Dates

• First Submitted: July 9, 2019
• First Posted: July 11, 2019
• Study Start: September 26, 2019
• Primary Completion: May 1, 2020
• Study Completion: May 1, 2020
• Last Updated: January 12, 2021

Record last verified: 2021-01

Locations

US (1)