Effect of Gene Polymorphism on Cognitive Function

NCT05879341 | Unknown

• 1 other identifier: KMUHIRB-G(I)-20220005
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to study the effect of gene polymorphism on cognitive improvement in response to exercise in healthy participants. The main questions it aims to answer are: To investigate whether FNDC5/Irisin genotype polymorphism affects cognitive function and inter-individual variability in exercise response. To explore whether the FNDC5/Irisin gene polymorphism can act alone or interact with the BDNF gene to cause inter-individual differences in cognitive function responses to exercise gain. Participants will be asked to perform high-intensity interval training( HIIT) on a cycle ergometer. Each high-intensity training period will be 30 seconds followed by a 4-minute rest period. The participants will also perform cognitive tests (Vistorian stroop test and Fitlight trainer test) before and after the exercise.

Conditions

Polymorphosis; Cognitive Function

Keywords

Irisin; Cognition; Polymorphism; High intensity interval training

Outcome Measures

Primary Outcomes (8)

• Change in Serum BDNF levels

  Serum brain derived neurotrophic factor levels

  The blood sample will be collected immediately after the participant has signed the consent to assess pre exercise BDNF levels

• Change in Serum BDNF levels

  Serum brain derived neurotrophic factor levels

  The blood sample will be collected 30 minutes after the participant has completed high intensity exercise to assess post exercise BDNF levels

• Change in Serum Irisin Levels

  Serum Irisin levels

  The blood sample will be collected immediately after the participant has signed the consent to assess pre exercise Irisin levels

• Change in Serum Irisin Levels

  Serum Irisin levels

  The blood sample will be collected 30 minutes after the participant has completed high intensity exercise to assess post exercise Irisin levels

• Change in Stroop Reaction time

  Reaction time for Victorian version of Stroop test

  Baseline

• Change in Stroop Reaction time

  Reaction time for Victorian version of Stroop test

  Immediately after the procedure

• Change in Fitlight reaction time

  Mean Reaction time to Fitlight Trainer complex patterns

  Baseline

• Change in Fitlight reaction time

  Mean Reaction time to Fitlight Trainer complex patterns

  Immediately after the procedure

Secondary Outcomes (3)

• Monitor the Heart rate

  During the procedure

• Change in Fitlight simple reaction time

  Baseline

• Change in Fitlight simple reaction time

  Immediately after the procedure

Interventions

High intensitiy interval training OTHER

The participants will perform HIIT at 85% of their heart rate reserve. There will be 8 cycles of high intensity with four minutes of rest intervals in between.

Also known as: HIIT, High intensity interval Exercise

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Taiwanese National who perform less than 120 minutes of aerobic exercise per week.

You may qualify if:

• Taiwanese National who perform less than 120 minutes of aerobic exercise per week.
• The subjects will refrain from drinking alcoholic or caffeinated drinks 24 hours prior to the participation in the study

You may not qualify if:

• Subjects who are diagnosed with
• Hypertension
• Arrhythmia
• Depression
• Color blindness
• Musculoskeletal injury within one year
• Body Mass index higher than 25
• Pregnant females

Sponsors & Collaborators

• Kaohsiung Medical University Chung-Ho Memorial Hospital: lead
• Ministry of Science and Technology, Taiwan: collaborator

Study Sites (1)

Kaohsiung Medical University

Kaohsiung City, 807, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample will be collected from the participants which will be used to extract serum and DNA. Serum will be used to measure Irisin and BDNF levels. DNA will be used for BDNF and Irisin SNP Geno-typing.

MeSH Terms

Interventions

High-Intensity Interval Training

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Dean-Chuan Wang, PhD

  Kaohsiung Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Dean-Chuan Wang, PhD

CONTACT

+886-7-3121101; dcw@kmu.edu.tw

Muhammad Asad Chaudhary, MS

CONTACT

+886983257673; asadchaudhary97@gmail.com

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 6, 2023
• First Posted: May 30, 2023
• Study Start: June 10, 2022
• Primary Completion: July 1, 2024
• Study Completion: July 1, 2024
• Last Updated: May 30, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)