Resistance Training on Growth Factors

NCT06114550 | Unknown

• 1 other identifier: zuochongwen
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:

1. 1.Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.
2. 2.whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.

Conditions

Cognitive Function

Keywords

neurotrophic growth factors; IGF-1; BDNF; VEGF; Irisin; Hcy

Outcome Measures

Primary Outcomes (7)

• Rata of perceived exertion

  The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.

  "0 minutes" "60 minutes" "90 minutes"

• Blood lactate

  serum blood lactate

  "0 minutes" "60 minutes" "90 minutes"

• BDNF

  regulators of neurogenesis

  "0 minutes" "60 minutes" "90 minutes"

• IGF-1

  regulators of neurogenesis

  "0 minutes" "60 minutes" "90 minutes"

• VEGF

  regulators of neurogenesis

  "0 minutes" "60 minutes" "90 minutes"

• Irisin

  regulators of neurogenesis

  "0 minutes" "60 minutes" "90 minutes"

• Hcy

  homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction

  "0 minutes" "60 minutes" "90 minutes"

Secondary Outcomes (2)

• Reactive time

  "0 minutes" "60 minutes" "90 minutes"

• Accuracy rate

  "0 minutes" "60 minutes" "90 minutes"

Study Arms (2)

High-intensity resistance training group (HIRT)

EXPERIMENTAL

All subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set.

Other: High intensity resistance training

low-intensity resistance training group (LIRT)

EXPERIMENTAL

All subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order.

Other: Low intensity resistance training

Interventions

High intensity resistance training OTHER

The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.

High-intensity resistance training group (HIRT)

Low intensity resistance training OTHER

For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.

low-intensity resistance training group (LIRT)

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age between 18 to 30 years
• no experiencing musculoskeletal disorders or sports injuries
• had not participated any regular aerobic endurance or resistance training with in the previous half years
• no smoking habit or intake alcohol and other medication (e.g., steroid hormone)
• good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)

You may not qualify if:

• experiencing musculoskeletal disorders or sports injuries in recent 1 month
• had regular resistance training exercise
• intake any supplementary(drug and hormone)

Sponsors & Collaborators

• Air Force Military Medical University, China: lead

Study Officials

• chongwen zuo, Doctoral

  Air Force Medical Center of Chinese PLA

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chongwen Zuo, Doctoral

CONTACT

+86 18810716505; zuochongwen@cupes.edu.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctoral

Study Record Dates

• First Submitted: October 24, 2023
• First Posted: November 2, 2023
• Study Start: February 27, 2024
• Primary Completion: March 30, 2024
• Study Completion: April 7, 2024
• Last Updated: February 1, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: SAP
• Time Frame: When this study was published.
• Access Criteria: Shall not be used for secondary analysis or repeated publication