Effects of Magnesium Supplementation on Hemodynamic Parameters and Cognitive Function
1 other identifier
interventional
50
1 country
1
Brief Summary
Using a double-blind randomized controlled trial design, this study intends to evaluate the short-term effect of magnesium citrate on cognitive functions and hemodynamic parameters in MCI elders, including Montreal Cognitive Assessment, working memory test-digit span test, carotid artery flow velocity, ankle-brachial blood pressure ratio, and urinary magnesium.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Oct 2018
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 22, 2018
CompletedFirst Posted
Study publicly available on registry
October 23, 2018
CompletedStudy Start
First participant enrolled
October 23, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2021
CompletedJanuary 26, 2022
January 1, 2022
8 months
October 22, 2018
January 25, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
End-diastolic velocity
End-diastolic velocity of internal carotid artery
Two hours from intervention to follow-up measurement
Study Arms (2)
Magnesium supplement group
EXPERIMENTALSubjects receive citrate acid drinks with additional magnesium citrate (300mg magnesium)
placebo group
PLACEBO COMPARATORSubjects receive citrate acid drinks without additional magnesium
Interventions
Pure Magnesium citrate powder 2.07 gram from NOW FOODS (Bloomingdale, IL, USA)
Food grade citrate acid 0.1 gram from San Fu Chemical Co., Ltd (Taipei, Taiwan)
Splenda 1.0 gram from Splenda(Carmel, Indiana, USA)
Eligibility Criteria
You may qualify if:
- Participants with mild cognitive impairment (Mini-Metal State Examination \< 26 points)
- Participants signing the informed consent form
You may not qualify if:
- Participants regularly taking magnesium supplements
- Participants who had severe illness (e.g. cancer, ridden bed)
- Participants unable to speak, with visual disorder and hearing impairment)
- Participants hospitalized who live in elderly homes
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Academia Sinica, Taiwanlead
- National Health Research Institutes, Taiwancollaborator
- Taipei Veterans General Hospital, Taiwancollaborator
Study Sites (1)
Academia Sinica
Taipei, 115, Taiwan
MeSH Terms
Interventions
Study Officials
- PRINCIPAL INVESTIGATOR
Wen-Harn Pan, Ph.D.
Institute of Biomedical Sciences, Academia Sinica
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, CARE PROVIDER
- Purpose
- PREVENTION
- Intervention Model
- SEQUENTIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Distinguished Research Fellow
Study Record Dates
First Submitted
October 22, 2018
First Posted
October 23, 2018
Study Start
October 23, 2018
Primary Completion
June 30, 2019
Study Completion
June 30, 2021
Last Updated
January 26, 2022
Record last verified: 2022-01