Brain Stimulation Effects on Cognitive Task Performance

NCT05556655 | Recruiting FDA Device

• 1 other identifier: 3502
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.

Conditions

Cognitive Function

Keywords

Transcranial Magnetic Stimulation; TMS

Outcome Measures

Primary Outcomes (2)

• Sternberg Memory Task (Accuracy)

  Mean item accuracy on a computerized Sternberg memory task.

  Single study appointment. 1 hour. There will be no follow up.

• Sternberg Memory Task (Reaction Time)

  Mean item reaction time on a computerized Sternberg memory task.

  Single study appointment. 1 hour. There will be no follow up.

Study Arms (2)

Active TMS

EXPERIMENTAL

Repetitive TMS for the brain

Device: Transcranial Magnetic Stimulation

Sham TMS

PLACEBO COMPARATOR

Scalp stimulation that does not affect the brain.

Device: Transcranial Magnetic Stimulation

Interventions

Transcranial Magnetic Stimulation DEVICE

Transcranial Magnetic Stimulation (TMS) is a noninvasive method for stimulating neurons (axons not cell bodies) in the brain.

Active TMS; Sham TMS

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Right-handed
• Fluent in English

You may not qualify if:

• History of seizures or epilepsy
• Family history of epilepsy
• Significant medical or neurological diagnoses
• History of common headache or migraine
• History of common or recent syncope
• History of moderate/severe, multiple mild, or past 12 months head injury
• History of psychiatric, psychological, or neurodevelopmental disorder
• History of alcohol or recreational drug abuse or dependence
• Current visual or hearing difficulties that interfere with cognitive testing
• History of cochlear implants
• Current pregnancy
• History of metal in the head or neck (except braces and fillings)
• Current non-removable piercings in the neck or head
• History of implanted neurostimulator
• History of cardiac pacemaker or intracardiac lines

Sponsors & Collaborators

• Colorado State University: lead

Study Sites (1)

Colorado State University Department of Psychology

Fort Collins, Colorado, 80523, United States

RECRUITING

MeSH Terms

Interventions

Transcranial Magnetic Stimulation

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics

Central Study Contacts

Michael Thomas, PhD

CONTACT

(970) 491-6820; Michael.L.Thomas@colostate.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants are blinded to TMS therapy, sham control
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Mechanistic study of impact of transcranial magnetic stimulation (TMS) on cognitive function.

Study Record Dates

• First Submitted: September 20, 2022
• First Posted: September 27, 2022
• Study Start: April 20, 2023
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): January 1, 2028
• Last Updated: April 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)