Brief Summary

The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of smoking and older adult smokers.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

150

participants targeted

Target at P75+ for not_applicable

Timeline

Completed

Started May 2023

Shorter than P25 for not_applicable

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

9 months study duration

First Submitted

Initial submission to the registry

May 9, 2023

Completed

9 days until next milestone

First Posted

Study publicly available on registry

May 18, 2023

Completed

12 days until next milestone

Study Start

First participant enrolled

May 30, 2023

Completed

9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 26, 2024

Completed

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 26, 2024

Completed

1.1 years until next milestone

Results Posted

Study results publicly available

April 10, 2025

Completed

Last Updated

April 10, 2025

Status Verified

March 1, 2025

Enrollment Period

9 months

First QC Date

May 9, 2023

Results QC Date

January 17, 2025

Last Update Submit

March 21, 2025

Conditions

Nicotine Nicotine Vaping E-cigarette Use

Outcome Measures

Primary Outcomes (3)

Behavioral Intentions for Continued Use
Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product.
The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.
Intensity of Sensory Attributes
5-item self-report measure completed following e-cigarette self-administration, using the general Labeled Magnitude Scale (gLMS). Scores range from 0 (no sensation) to 100 (strongest imaginable) with higher scores indicating a greater sensation intensity.
The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.
Degree of Liking or Disliking of Sensations
Self-report measure completed following e-cigarette self-administration, using the Labeled Hedonic Scale (LHS). Scores range from -100 (most disliked imaginable) to 100 (most liked imaginable) with higher scores indicating a greater degree of liking.
The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

Secondary Outcomes (1)

Subjective Appeal
The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.

Study Arms (2)

Young adult EC users

ACTIVE COMPARATOR

Young Adult EC users

Behavioral: Vaping study EC ABehavioral: Vaping study EC BBehavioral: Vaping study EC CBehavioral: Vaping study EC DBehavioral: Vaping study EC EBehavioral: Vaping study EC FBehavioral: Vaping study EC GBehavioral: Vaping study EC HBehavioral: Vaping study EC IBehavioral: Vaping study EC J

Older adult smokers

ACTIVE COMPARATOR

Adult smokers