Brief Summary

This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

participants targeted

Target at P25-P50 for not_applicable

Timeline

Completed

Started Jun 2022

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

11 months study duration

First Submitted

Initial submission to the registry

December 14, 2021

Completed

22 days until next milestone

First Posted

Study publicly available on registry

January 5, 2022

Completed

6 months until next milestone

Study Start

First participant enrolled

June 29, 2022

Completed

11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 2, 2023

Completed

5 days until next milestone

Study Completion

Last participant's last visit for all outcomes

June 7, 2023

Completed

1.3 years until next milestone

Results Posted

Study results publicly available

September 26, 2024

Completed

Last Updated

January 30, 2025

Status Verified

August 1, 2024

Enrollment Period

11 months

First QC Date

December 14, 2021

Results QC Date

August 30, 2024

Last Update Submit

January 28, 2025

Conditions

Cigarette Smoking Nicotine Vaping

Outcome Measures

Primary Outcomes (2)

Nicotine/Tobacco Products Substitution
Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will depend on the experimental condition. The degree to which other nicotine/tobacco products substitute for conventional cigarettes as a function of novel product (e.g. nicotine vaping products, heated tobacco products, nicotine pouch products) prices will be assessed. To obtain estimates of substitution of price-constant products in the different ETM conditions, the investigators will use ordinary least squares regression to model the relationship of the price-manipulated product to predict total quantity purchased of the price-constant product.
1 day
Cigarette Demand
Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will depend on the experimental condition. The degree to which other nicotine/tobacco products substitute for conventional cigarettes as a function of novel product (e.g. nicotine vaping products, heated tobacco products, nicotine pouch products) prices will be assessed. To obtain dependent measures of demand, participants' purchasing of the price-manipulated commodity in the ETM task will be fit to a modified exponential equation to quantify the relationship between the price of each commodity and purchasing: Q=Q0\*10k(exp(-αQ0C)-1) where Q is purchasing of the commodity, C is the price, Q0 is the derived initial purchasing without cost constraints (demand intensity), k is the span of the function in logarithmic units, and α is the demand elasticity.
1 day

Study Arms (2)

Exclusive cigarette smokers

EXPERIMENTAL

Exclusive cigarette smokers will be recruited and will be exposed to all of the conditions described in the intervention section.

Other: All nicotine/ tobacco products at market priceOther: Nicotine vaping products at 1/2 market priceOther: Nicotine vaping products at 2x market priceOther: Heated tobacco products at 1/2 market price.Other: Heated tobacco products at 2x market price.Other: Nicotine pouch products at 1/2 market price.Other: Nicotine pouch products at 2x market price.

Dual cigarette/ nicotine vaping product users

EXPERIMENTAL

Dual cigarette and nicotine vaping product users will be recruited and will be exposed to all of the conditions described in the intervention section.

Interventions

All nicotine/ tobacco products at market priceOTHER

Nicotine/tobacco products available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.