NCT06129123

Brief Summary

The goal of this intervention development and pilot clinical trial is to determine whether receiving the brief online intervention results in greater reductions in past 7-day e-cigarette use frequency and smoking susceptibility over an 8-week period compared to receiving the control condition in young adults who currently use e-cigarettes. Participants in the experimental condition will be asked to complete the 30-minute mobile-based program. Participants in the assessment-only control will be given the option to access the intervention after they complete their final survey at 8 weeks. All participants will complete our online surveys at baseline as well as 2-weeks, 4-weeks, and 8-weeks post-randomization. Researchers will compare outcomes among the intervention and control groups to determine the efficacy of the intervention.

Trial Health

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Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 8, 2023

Completed
5 days until next milestone

First Posted

Study publicly available on registry

November 13, 2023

Completed
1.6 years until next milestone

Study Start

First participant enrolled

July 1, 2025

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 23, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 23, 2026

Completed
Last Updated

January 16, 2026

Status Verified

January 1, 2026

Enrollment Period

7 months

First QC Date

November 8, 2023

Last Update Submit

January 14, 2026

Conditions

E-cigarette Use

Outcome Measures

Primary Outcomes (2)

  • E-cigarette Use

    Participants will report the number of (1) days they vaped, (2) times they picked up their device to vape per day, and (3) puffs they took before putting their vaping device away per day in the past 7 days and 30 days

    8 weeks

  • Smoking Susceptibility

    4-item Expanded Susceptibility to Smoking Index (ESSI)

    8 weeks

Secondary Outcomes (6)

  • Perceived harms and benefits of vaping

    8 weeks

  • Perceived harms and benefits of smoking

    8 weeks

  • Motivation to vape

    8 weeks

  • Motivation to smoke

    8 weeks

  • Quitting vaping self-efficacy

    8 weeks

  • +1 more secondary outcomes

Study Arms (2)

Intervention

EXPERIMENTAL

Participants will be asked to complete a 30-minute intervention that is accessible on a mobile device, delivered via a webpage, and personalized to their individual vaping behavior and beliefs (based on the baseline surveys). The intervention will contain personalized normative feedback (PNF), Motivational Enhancement (ME), and education. Participants will complete assessments at baseline as well as 2-weeks, 4-weeks, and 8-weeks post randomization.

Behavioral: Live Free From E-cigarettes

Waitlist Control

NO INTERVENTION

Participants will complete assessments at baseline as well as 2-weeks, 4-weeks, and 8-weeks post randomization. They will not receive the intervention during the active study phase, lasting 8 weeks. Participants will have the option to access the intervention once this active study phase is over.

Interventions

Live Free From E-cigarettesBEHAVIORAL

This is a 30-minute online educational program that focuses on providing information about e-cigarette and smoking social norms, harms of e-cigarettes and cigarettes, and ways to quit or reduce using e-cigarettes.

Intervention

Eligibility Criteria

Age18 Years - 24 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • be between the ages of 18 to 24
  • be able to read English
  • report vaping at least one day per week in the past month
  • report no history of cigarette use at screening and baseline.

You may not qualify if:

  • reporting severe mental health, illicit drug use, or alcohol use disorder
  • currently receiving nicotine cessation services

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Southern California

Los Angeles, California, 90089, United States

RECRUITING

Related Publications (1)

  • Tran DD, Davis JP, Buch K, Leventhal AM, Ewing SWF, Pedersen ER. A novel online vaping intervention and smoking prevention program for young adults who vape: protocol for a randomized controlled trial. Addict Sci Clin Pract. 2025 Apr 21;20(1):36. doi: 10.1186/s13722-025-00566-x.

    PMID: 40259422DERIVED

MeSH Terms

Conditions

Vaping

Condition Hierarchy (Ancestors)

SmokingBehavior

Study Officials

  • Denise D Tran, PhD

    University of Southern California

    PRINCIPAL INVESTIGATOR

Central Study Contacts

I-Wen Contracts and Grants Coordinator

CONTACT

310-918-0538i-wen.lai@med.usc.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

November 8, 2023

First Posted

November 13, 2023

Study Start

July 1, 2025

Primary Completion

January 23, 2026

Study Completion

January 23, 2026

Last Updated

January 16, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

No identifying participant information will be shared with other researchers. In the case where another researcher requests access to our data, we will de-identify our data set before sharing these data.

Locations

US(1)