Comparison of QLB Block and TAP Block in Morbid Obese Patients

NCT05820620 | Completed DMC

• 1 other identifier: 2015-KAEK-76-23-02
• Study Type: interventional
• Target: 124
• Locations: 1 country
• Sites: 2

Brief Summary

Quadratus lumborum block (QLB) and Transversus abdominis plane (TAP) blocks are regional anesthesia techniques that are frequently used to reduce postoperative pain and are an important part of the current analgesic regimen for many abdominal surgeries. In our clinic, researchers perform both blocks to provide postoperative analgesia. The primary aim of our study is to compare the effectiveness of TAP block and QLB block in postoperative pain control in laparoscopic sleeve gastrectomy. Secondary outcomes evaluated in this study were to assess postoperative nausea and vomiting (PONV), time to discharge, and patient satisfaction.

Conditions

Pain, Postoperative

Keywords

Morbid Obesity; TAP Block; QLB block; Analgesia

Outcome Measures

Primary Outcomes (2)

• Pain management

  VAS value (Visual Analogue Scale) : 10cm line, with two end points representing 0 ('no pain') and 10 ('pain as bad as it could possibly be')

  24th hours after surgery

• Pain management

  Morphine consumption

  24th hours after surgery

Secondary Outcomes (1)

• Patient Satisfaction

  Preoperative and after 7 days

Study Arms (3)

Control group

PLACEBO COMPARATOR

No intervention + Patient Control Analgesia (PCA)

Other: Control Group

QLB group

EXPERIMENTAL

QLB group Block will be applied + Patient Control Analgesia (PCA)

Procedure: QLB block

TAP group

EXPERIMENTAL

TAP Block group will be applied + Patient Control Analgesia (PCA)

Procedure: TAP block

Interventions

TAP block PROCEDURE

The transversus abdominis plane (TAP) block was introduced as a landmark-guided technique via the triangle of Petit to achieve a field block. It involves the injection of a local anesthetic solution into a plane between the internal oblique muscle and transversus abdominis muscle.

Also known as: Transversus abdominis plane (TAP)

TAP group

QLB block PROCEDURE

Quadratus lumborum block is a block of the posterior abdominal wall, "interfascial plane block," which is performed exclusively under ultrasound guidance. It was described as a variant of the TAP block.

Also known as: Quadratus lumborum block (QLB)

QLB group

Control Group OTHER

Control Group + Patient Control Analgesia (PCA)

Control group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI\> 35 kg/m2
• Laparoscopic sleeve gastrectomy operation
• ASA I-III
• General anesthesia will be applied and patients who agree to participate in the study will be included.

You may not qualify if:

• Patients younger than 18 years of age
• Bleeding disorders (INR: 1.2, antithrombotic, antiaggregant drug use, hematological disorders, etc.) That are contraindications for regional anesthesia, and those with infection at the planned skin site
• Psychiatric or neurological disorders, and substance addictions

Sponsors & Collaborators

• Biruni University: lead

Study Sites (2)

Suna Koç

Istanbul, Besyol, 34295, Turkey (Türkiye)

Location

Suna Koç

Istanbul, Kucukcekmece, 34295, Turkey (Türkiye)

Location

Related Publications (7)

• 1. Sarandan M, Balasa CG, Papurica M et al (2011) Anesthesia in laparoscopic bariatric surgery (gastric sleeve) preliminary experience. TMJ 61:1-2

  RESULT

• 2. Melzack R, Katz J (1994) Pain measurements in persons in pain. In Wall PD, Melzack R (Eds) Textbook of pain. Churchill Livingstone, Edinburgh, pp 409-426

  RESULT

• Macintyre PE, Loadsman JA, Scott DA. Opioids, ventilation and acute pain management. Anaesth Intensive Care. 2011 Jul;39(4):545-58. doi: 10.1177/0310057X1103900405.

  PMID: 21823370 RESULT

• Sinclair DR, Chung F, Mezei G. Can postoperative nausea and vomiting be predicted? Anesthesiology. 1999 Jul;91(1):109-18. doi: 10.1097/00000542-199907000-00018.

  PMID: 10422935 RESULT

• Niraj G, Searle A, Mathews M, Misra V, Baban M, Kiani S, Wong M. Analgesic efficacy of ultrasound-guided transversus abdominis plane block in patients undergoing open appendicectomy. Br J Anaesth. 2009 Oct;103(4):601-5. doi: 10.1093/bja/aep175. Epub 2009 Jun 26.

  PMID: 19561014 RESULT

• 6. Bisgaard T (2006) Laparoskopik kolesistektomi sonrası analjezik tedavisi. Anesteziyoloji 104:835-846

  RESULT

• Emile SH, Abdel-Razik MA, Elbahrawy K, Elshobaky A, Shalaby M, Elbaz SA, Gado WA, Elbanna HG. Impact of Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative Pain and Early Outcome After Laparoscopic Bariatric Surgery: a Randomized Double-Blinded Controlled Trial. Obes Surg. 2019 May;29(5):1534-1541. doi: 10.1007/s11695-019-03720-y.

  PMID: 30706309 RESULT

MeSH Terms

Conditions

Pain, Postoperative; Obesity, Morbid; Agnosia

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• Mehmet I Buget, Assoc Prof

  Biruni Universty

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor Dr

Model Details: After the patients are routinely put to sleep, TAP block will be applied to the 1st group, QLB block will be applied to the 2nd group, and no intervention will be performed to the 3rd group as it is the control group.

Study Record Dates

• First Submitted: March 27, 2023
• First Posted: April 19, 2023
• Study Start: April 20, 2023
• Primary Completion: February 20, 2024
• Study Completion: February 21, 2024
• Last Updated: February 21, 2024

Record last verified: 2024-02

Locations

TU (2)