Postoperative Analgesic Efficacy of Adjuvant Quadratus Lumborum Block in Open Inguinal Hernia Surgery

NCT06664164 | Completed

• 1 other identifier: GAZIAOSMANPASA TREHAQ
• Study Type: interventional
• Target: 67
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluation of Postoperative Analgesic Efficacy of Adjuvant Use in Quadratus Lumborum Blocks

Conditions

Pain, Postoperative

Keywords

anterior quadratus lumborum block; postoperative pain; adjuvant; dexamethasone; inguinal hernia

Outcome Measures

Primary Outcomes (1)

• time to first rescue analgesic requirement.

  Compare the time to first rescue analgesia in patients

  24 hour

Secondary Outcomes (3)

• Total analgesic Consumption

  24 hour

• To compare the NRS (Numering rating scale) values (resting and dynamic) at 4. 8. 12 . 24. hours in the postoperative follow-up of the patients

  24 hour

• To compare postoperative side effects such as nausea, vomiting

  24 hour

Study Arms (2)

QLB Group

ACTIVE COMPARATOR

anterior quadratus lumborum block group

Procedure: ANTERİOR QUADRATUS LUMBORUM BLOCK

adjuvant QLB Group

ACTIVE COMPARATOR

with adjuvant anterior quadratus lumborum block group

Procedure: ANTERİOR QUADRATUS LUMBORUM BLOCK WİTH ADJUVANT

Interventions

ANTERİOR QUADRATUS LUMBORUM BLOCK PROCEDURE

Patients are placed in the lateral decubitus position. The area where the block will be applied is disinfected with povidine iodine. A convex ultrasound probe is placed on the midaxillary line above the iliac crest. By visualizing the transverse process adjacent to the psoas major and quadratus lumborum muscles, using the in-plane technique, using a 22 gauge 80 mm peripheral block needle after negative aspiration into the anterior layer of the thoracolumbar fascia anterior to the quadratus lumborum muscle muscle, 0.5-1 ml of serum After observing hydrodissection with physiological, 20 ml of 0.25% bupivacaine is injected.

QLB Group

ANTERİOR QUADRATUS LUMBORUM BLOCK WİTH ADJUVANT PROCEDURE

Patients are placed in the lateral decubitus position. The area where the block will be applied is disinfected with povidine iodine. A convex ultrasound probe is placed on the midaxillary line above the iliac crest. By visualizing the transverse process adjacent to the psoas major and quadratus lumborum muscles, using the in-plane technique, using a 22 gauge 80 mm peripheral block needle after negative aspiration into the anterior layer of the thoracolumbar fascia anterior to the quadratus lumborum muscle muscle, 0.5-1 ml of serum After observing hydrodissection with physiological, 20 ml of 0.25% bupivacaine and 8 mg de-xamethasone are injected.

adjuvant QLB Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• local anesthetic allergy
• Infection at the procedure site
• Body Mass Index \>35 kg/m2
• Anticoagulant use with bleeding disorder
• Chronic analgesia and opioid use -with mental and psychiatric disorders -

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

Study Sites (1)

Gaziosmanpasa Research and Training Hospital

Istanbul, 34255, Turkey (Türkiye)

Location

Related Publications (2)

• Priyadarshini K, Behera BK, Tripathy BB, Misra S. Ultrasound-guided transverse abdominis plane block, ilioinguinal/iliohypogastric nerve block, and quadratus lumborum block for elective open inguinal hernia repair in children: a randomized controlled trial. Reg Anesth Pain Med. 2022 Apr;47(4):217-221. doi: 10.1136/rapm-2021-103201. Epub 2022 Jan 17.

  PMID: 35039439 BACKGROUND

• Favaro ML, Gabor S, Souza DBF, Araujo AA, Milani ALC, Ribeiro Junior MAF. Quadratus Lumborum Block As A Single Anesthetic Method For Laparoscopic Totally Extraperitoneal (Tep) Inguinal Hernia Repair: A Randomized Clinical Trial. Sci Rep. 2020 May 22;10(1):8526. doi: 10.1038/s41598-020-65604-x.

  PMID: 32444629 BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative; Hernia, Inguinal

Interventions

Adjuvants, Pharmaceutic

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Hernia, Abdominal; Hernia; Pathological Conditions, Anatomical

Intervention Hierarchy (Ancestors)

Pharmaceutic Aids; Pharmaceutical Preparations; Specialty Uses of Chemicals; Chemical Actions and Uses

Study Officials

• Serpil Sehirlioglu, MD

  Gaziosmanpasa Research and Training Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Everyone except the person preparing the medication for the patient will be blinded. The person performing the block, the participants, and those monitoring during the postoperative period will be blinded to the study.
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: October 27, 2024
• First Posted: October 29, 2024
• Study Start: November 1, 2024
• Primary Completion: August 12, 2025
• Study Completion: August 13, 2025
• Last Updated: August 28, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: always
• Access Criteria: drserpilsahin@gmail.com

Locations

TU (1)