Study of Cerebral Activation by fNIRS During Gait With Different Rhythmic Auditory Stimulations in Healthy Subjects

NCT05789121 | Completed

• 1 other identifier: CHRO-2022-09
• Study Type: observational
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the cerebral activation in healthy subjects in 4 conditions of gait :

• Gait at preferred cadence without auditory stimulation (Gait1)
• Gait with low tempo rhythmic auditory stimulation by music (RAS-Slow). The beat rate of the music was 68.5 per minute for all participants.
• Gait with fast tempo synchronous rhythmic auditory stimulation by music (RAS-Fast). The beat rate of the music was set to 10% above each patient's preferred gait cadence . The preferred cadence was considered as the mean of the 6 trials during Gait 1.
• Gait without auditory stimulation (Gait2) The investigators goal is to compare cerebral activation and gait parameters during the 4 different tasks using fNIRS.

Conditions

Healthy

Keywords

Rhythmic auditory stimulation; Gait; Near infrared spectroscopy

Outcome Measures

Primary Outcomes (2)

• Mean change in the concentration of oxyhemoglobin during the task

  Day 0

• Mean change in the concentration of deoxyhemoglobin during the task

  Day 0

Secondary Outcomes (4)

• Walking speed

  Day 0

• Number of steps within a minute walk (in steps/min)

  Day 0

• stride length

  Day 0

• double support time

  Day 0

Study Arms (1)

Healthy subjects

30 healthy subject aged between 18 and 40.

Device: walking 25 m in 4 different conditions

Interventions

walking 25 m in 4 different conditions DEVICE

The protocol consisted of walking 25 m in 4 different conditions in the following order: Gait1, RAS-Slow, RAS-fast, Gait2. * Gait 1 : preferred cadence without auditory stimulation * RAS-Slow : Gait with low tempo rhythmic auditory stimulation by music (68.5 per minute). * RAS-Fast : Gait with fast tempo (10% above each Gait1 cadence). * Gait2 : preferred cadence without auditory stimulation

Healthy subjects

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy subjects aged between 18 and 40 years

You may qualify if:

• Age 18 to 40 years old.
• No known neurological disease
• Benefiting from a social security coverage.
• Sufficient knowledge of the French language to understand the instructions

You may not qualify if:

• Person under tutorship or curatorship
• Known allergy to components of the fNIRS device: neoprene
• History of neurological disease
• History of rheumatological disease affecting walking
• Pregnant or breastfeeding women
• Subjects opposed to participating in the study

Sponsors & Collaborators

• Centre Hospitalier Régional d'Orléans: lead

Study Sites (1)

CHR Orléans

Orléans, 45067, France

Location

Related Publications (7)

• Altenmuller E, Schlaug G. Apollo's gift: new aspects of neurologic music therapy. Prog Brain Res. 2015;217:237-52. doi: 10.1016/bs.pbr.2014.11.029. Epub 2015 Feb 11.

  PMID: 25725918 BACKGROUND

• Bonnal J, Monnet F, Le BT, Pila O, Grosmaire AG, Ozsancak C, Duret C, Auzou P. Relation between Cortical Activation and Effort during Robot-Mediated Walking in Healthy People: A Functional Near-Infrared Spectroscopy Neuroimaging Study (fNIRS). Sensors (Basel). 2022 Jul 25;22(15):5542. doi: 10.3390/s22155542.

  PMID: 35898041 BACKGROUND

• Braunlich K, Seger CA, Jentink KG, Buard I, Kluger BM, Thaut MH. Rhythmic auditory cues shape neural network recruitment in Parkinson's disease during repetitive motor behavior. Eur J Neurosci. 2019 Mar;49(6):849-858. doi: 10.1111/ejn.14227. Epub 2018 Dec 3.

  PMID: 30375083 BACKGROUND

• Farid L, Jacobs D, Do Santos J, Simon O, Gracies JM, Hutin E. FeetMe(R) Monitor-connected insoles are a valid and reliable alternative for the evaluation of gait speed after stroke. Top Stroke Rehabil. 2021 Mar;28(2):127-134. doi: 10.1080/10749357.2020.1792717. Epub 2020 Jul 13.

  PMID: 32654627 BACKGROUND

• Koshimori Y, Thaut MH. Future perspectives on neural mechanisms underlying rhythm and music based neurorehabilitation in Parkinson's disease. Ageing Res Rev. 2018 Nov;47:133-139. doi: 10.1016/j.arr.2018.07.001. Epub 2018 Jul 10.

  PMID: 30005957 BACKGROUND

• Merchant H, Grahn J, Trainor L, Rohrmeier M, Fitch WT. Finding the beat: a neural perspective across humans and non-human primates. Philos Trans R Soc Lond B Biol Sci. 2015 Mar 19;370(1664):20140093. doi: 10.1098/rstb.2014.0093.

  PMID: 25646516 BACKGROUND

• Thaut MH. The discovery of human auditory-motor entrainment and its role in the development of neurologic music therapy. Prog Brain Res. 2015;217:253-66. doi: 10.1016/bs.pbr.2014.11.030. Epub 2015 Feb 2.

  PMID: 25725919 BACKGROUND

Study Officials

• Auzou PASCAL, Dr

  CHR d'Orleans

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2023
• First Posted: March 29, 2023
• Study Start: March 14, 2023
• Primary Completion: March 24, 2023
• Study Completion: March 24, 2023
• Last Updated: March 31, 2023

Record last verified: 2023-03

Locations

FR (1)