Evaluation of the Impact of Laterality on Brain Activation During a Virtual Mirror Therapy Task in Healthy Subjects

NCT05793762 | Completed

• 1 other identifier: CHRO-2022-17
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the differences in brain activation in healthy subjects during virtual mirror therapy tasks, depending on the laterality of the task. It seems that mirror therapy-related brain activation is greater when the visual feedback represents the non-dominant hand. The aim of this study is to highlight brain activation profiles during the use of virtual mirror therapy according to the lateralization of the feedback.

Conditions

Healthy

Keywords

mirror therapy; laterality; cortical activation; functional near-infrared spectroscopy; upper limb

Outcome Measures

Primary Outcomes (2)

• Mean change in the concentration of oxyhemoglobin during the task

  Changes in the concentration of oxyhemoglobin during the task measured with fnirs device

  Baseline

• Mean change in the concentration of deoxyhemoglobin during the task

  Changes in the concentration of deoxyhemoglobin during the task measured with fnirs device

  Baseline

Secondary Outcomes (2)

• Compare the cortical regions involved during the different mirror therapy tasks

  Baseline

• Compare the feelings of the subjects

  Baseline

Study Arms (1)

Healthy participants

30 right handed healthy participants aged between 18 and 60.

Device: Left virtual mirror therapy task; Device: Right virtual mirror therapy task

Interventions

Left virtual mirror therapy task DEVICE

the participant is seated on a chair facing the screen of the virtual mirror therapy device. both hands resting under the screen. The participant is asked, for each block of 20 seconds, to observe the visual feedback of the virtual left hand on the screen (flexion / extension movements of the fingers at 0.5 Hz).

Healthy participants

Right virtual mirror therapy task DEVICE

the participant is seated on a chair facing the screen of the virtual mirror therapy device. both hands resting under the screen. The participant is asked, for each block of 20 seconds, to observe the visual feedback of the virtual right hand on the screen (flexion / extension movements of the fingers at 0.5 Hz).

Healthy participants

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

right handed healthy subjects aged between 18 and 60

You may qualify if:

• Age:18 to 60
• Right handed
• No neurological disease

You may not qualify if:

• Person under tutorship or curatorship
• Known allergy to components of the fNIRS device: neoprene

Sponsors & Collaborators

• Centre Hospitalier Régional d'Orléans: lead

Study Sites (1)

CHR Orléans

Orléans, 45067, France

Location

Related Publications (10)

• Bartur G, Pratt H, Dickstein R, Frenkel-Toledo S, Geva A, Soroker N. Electrophysiological manifestations of mirror visual feedback during manual movement. Brain Res. 2015 May 5;1606:113-24. doi: 10.1016/j.brainres.2015.02.029. Epub 2015 Feb 23.

  PMID: 25721791 BACKGROUND

• Altschuler EL, Wisdom SB, Stone L, Foster C, Galasko D, Llewellyn DM, Ramachandran VS. Rehabilitation of hemiparesis after stroke with a mirror. Lancet. 1999 Jun 12;353(9169):2035-6. doi: 10.1016/s0140-6736(99)00920-4. No abstract available.

  PMID: 10376620 BACKGROUND

• Chang CS, Lo YY, Chen CL, Lee HM, Chiang WC, Li PC. Alternative Motor Task-Based Pattern Training With a Digital Mirror Therapy System Enhances Sensorimotor Signal Rhythms Post-stroke. Front Neurol. 2019 Nov 22;10:1227. doi: 10.3389/fneur.2019.01227. eCollection 2019.

  PMID: 31824406 BACKGROUND

• Ferrari M, Quaresima V. A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application. Neuroimage. 2012 Nov 1;63(2):921-35. doi: 10.1016/j.neuroimage.2012.03.049. Epub 2012 Mar 28.

  PMID: 22510258 BACKGROUND

• Giraux P, Sirigu A. Illusory movements of the paralyzed limb restore motor cortex activity. Neuroimage. 2003 Nov;20 Suppl 1:S107-11. doi: 10.1016/j.neuroimage.2003.09.024.

  PMID: 14597303 BACKGROUND

• Lee SH, Jin SH, An J. The difference in cortical activation pattern for complex motor skills: A functional near- infrared spectroscopy study. Sci Rep. 2019 Oct 1;9(1):14066. doi: 10.1038/s41598-019-50644-9.

  PMID: 31575954 BACKGROUND

• Michielsen ME, Selles RW, van der Geest JN, Eckhardt M, Yavuzer G, Stam HJ, Smits M, Ribbers GM, Bussmann JB. Motor recovery and cortical reorganization after mirror therapy in chronic stroke patients: a phase II randomized controlled trial. Neurorehabil Neural Repair. 2011 Mar-Apr;25(3):223-33. doi: 10.1177/1545968310385127. Epub 2010 Nov 4.

  PMID: 21051765 BACKGROUND

• Ramachandran VS, Rogers-Ramachandran D, Cobb S. Touching the phantom limb. Nature. 1995 Oct 12;377(6549):489-90. doi: 10.1038/377489a0. No abstract available.

  PMID: 7566144 BACKGROUND

• Thieme H, Morkisch N, Mehrholz J, Pohl M, Behrens J, Borgetto B, Dohle C. Mirror therapy for improving motor function after stroke. Cochrane Database Syst Rev. 2018 Jul 11;7(7):CD008449. doi: 10.1002/14651858.CD008449.pub3.

  PMID: 29993119 BACKGROUND

• Wang J, Fritzsch C, Bernarding J, Krause T, Mauritz KH, Brunetti M, Dohle C. Cerebral activation evoked by the mirror illusion of the hand in stroke patients compared to normal subjects. NeuroRehabilitation. 2013;33(4):593-603. doi: 10.3233/NRE-130999.

  PMID: 24018372 BACKGROUND

Study Officials

• Julien BONNAL

  CHR d'Orléans

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 8, 2023
• First Posted: March 31, 2023
• Study Start: March 9, 2023
• Primary Completion: March 23, 2023
• Study Completion: March 23, 2023
• Last Updated: May 6, 2023

Record last verified: 2023-05

Locations

FR (1)