Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)

NCT06740136 | Recruiting

• 2 other identifiers: 2022-0072022-A01308-35
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.

Conditions

Healthy

Keywords

Muscle damage; Single nucleotide polymorphism; exercise

Outcome Measures

Primary Outcomes (1)

• The association between single nucleotide polymorphisms and exercise induced blood creatine kinase variation

  Association between blood creatine kinase level variations and single nucleotide polymorphisms. The Outcome Measure in this study is focused on the variation in plasma CPK levels following an exercise inducing muscle damage. The result is expressed as a change in plasma CPK concentration, measured in units per liter (U/L). This single measurement is used to investigate its association with genetic polymorphisms. Therefore a regression analysis will be performed to identify the association. This study is exploratory and the genetic polymorphisms are not pre-identified but will be investigated through a comprehensive analysis.

  Evolution of kinetics from Day 0 to Day 3 post experiment

Study Arms (1)

Exercise

EXPERIMENTAL

exercise group

Other: Exercise

Interventions

Exercise OTHER

Muscle induced-damage eccentric exercise

Exercise

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female
• Aged between 18 and 35
• Weighing more than 50 kg
• Member of a sports club affiliated to an Olympic federation
• Socially insured
• Willing to comply with all study procedures and duration of the study

You may not qualify if:

• Medical history contraindicating sporting activities
• Current medical treatment
• Not a member of a sports club affiliated to an Olympic federation
• Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.

Sponsors & Collaborators

• Lille University: lead

Study Sites (1)

Eurasport

Loos, 59120, France

RECRUITING

Related Links

• Related Info

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Intervention model

Study Record Dates

• First Submitted: December 10, 2024
• First Posted: December 18, 2024
• Study Start: March 13, 2023
• Primary Completion: June 28, 2024
• Study Completion: December 19, 2025
• Last Updated: December 18, 2024

Record last verified: 2024-12

Locations

FR (1)