Study of Cortical Activation During Hand and Shoulder Movements in Healthy Subjects

NCT05691777 | Completed

• 1 other identifier: CHRO-2020-04
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Characterization of cortical activation patterns during movements in healthy adults may help our understanding of how the injured brain works. Upper limb motor tasks are commonly used to assess impaired motor function and to predict recovery in individuals with neurological disorders such as stroke. This study aimed to explore cortical activation patterns associated with movements of the hand and shoulder using functional near-infrared spectroscopy (fNIRS). The investigators hypothesized that the activation pattern observed with fNIRS would differ for shoulder and hand movements. More specifically, the investigators hypothesized that the cerebral activation during hand movements would mainly involve the contralateral hemisphere, particularly the lateral part of primary motor cortex; whereas activation during shoulder movements would be more medial and more extensive than that of the hand.

Conditions

Healthy

Keywords

cortical activation; functional near-infrared spectroscopy; upper limb; motricity

Outcome Measures

Primary Outcomes (1)

• Mean change in the concentration of oxyhemoglobin and deoxyhemoglobin during the task

  Changes in the concentration of oxyhemoglobin and deoxyhemoglobin during the task measured with fNIRS device

  Day 0

Study Arms (1)

Healthy participants

right handed healthy participants aged between 18 and 40.

Device: Hand and shoulder task

Interventions

Hand and shoulder task DEVICE

Hand task: the participant is seated on a chair facing a table, both hands resting on the table. The participant is asked, for each block of 10 seconds, to perform flexion / extension movements of the fingers of the right hand at 0.5 Hz. Shoulder task: the participant is seated on a chair facing a table, both hands resting on the table. The participant is asked, for each block of 10 seconds, to perform alternating movement of abduction and adduction of the right shoulder at 0.5 Hz with the elbow flexed.

Healthy participants

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

right handed healthy subjects aged between 18 and 40

You may qualify if:

• Age:18 to 40
• Right handed
• No neurological, rhumatological or cardiac disease
• Having social security coverage
• Having expressed his non-objection

You may not qualify if:

• Person under tutorship or curatorship
• Known allergy to components of the fNIRS device: neoprene
• Person with known vascular problems

Sponsors & Collaborators

• Centre Hospitalier Régional d'Orléans: lead

Study Sites (1)

CHR Orléans

Orléans, 45067, France

Location

Related Publications (10)

• Nudo RJ, Milliken GW. Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys. J Neurophysiol. 1996 May;75(5):2144-9. doi: 10.1152/jn.1996.75.5.2144.

  PMID: 8734610 BACKGROUND

• Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC. Is neural activation within the rescued penumbra impeded by selective neuronal loss? Brain. 2013 Jun;136(Pt 6):1816-29. doi: 10.1093/brain/awt112. Epub 2013 May 16.

  PMID: 23682070 BACKGROUND

• Csipo T, Mukli P, Lipecz A, Tarantini S, Bahadli D, Abdulhussein O, Owens C, Kiss T, Balasubramanian P, Nyul-Toth A, Hand RA, Yabluchanska V, Sorond FA, Csiszar A, Ungvari Z, Yabluchanskiy A. Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans. Geroscience. 2019 Oct;41(5):495-509. doi: 10.1007/s11357-019-00122-x. Epub 2019 Nov 2.

  PMID: 31676966 BACKGROUND

• Delorme M, Vergotte G, Perrey S, Froger J, Laffont I. Time course of sensorimotor cortex reorganization during upper extremity task accompanying motor recovery early after stroke: An fNIRS study. Restor Neurol Neurosci. 2019;37(3):207-218. doi: 10.3233/RNN-180877.

  PMID: 31227675 BACKGROUND

• Kato J, Yamada T, Kawaguchi H, Matsuda K, Higo N. Functional near-infrared-spectroscopy-based measurement of changes in cortical activity in macaques during post-infarct recovery of manual dexterity. Sci Rep. 2020 Apr 15;10(1):6458. doi: 10.1038/s41598-020-63617-0.

  PMID: 32296087 BACKGROUND

• Lee SH, Jin SH, An J. The difference in cortical activation pattern for complex motor skills: A functional near- infrared spectroscopy study. Sci Rep. 2019 Oct 1;9(1):14066. doi: 10.1038/s41598-019-50644-9.

  PMID: 31575954 BACKGROUND

• Yang CL, Lim SB, Peters S, Eng JJ. Cortical Activation During Shoulder and Finger Movements in Healthy Adults: A Functional Near-Infrared Spectroscopy (fNIRS) Study. Front Hum Neurosci. 2020 Jul 8;14:260. doi: 10.3389/fnhum.2020.00260. eCollection 2020.

  PMID: 32733221 BACKGROUND

• Yeo SS, Chang PH, Jang SH. The cortical activation differences between proximal and distal joint movements of the upper extremities: a functional NIRS study. NeuroRehabilitation. 2013;32(4):861-6. doi: 10.3233/NRE-130910.

  PMID: 23867412 BACKGROUND

• Pinti P, Tachtsidis I, Hamilton A, Hirsch J, Aichelburg C, Gilbert S, Burgess PW. The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience. Ann N Y Acad Sci. 2020 Mar;1464(1):5-29. doi: 10.1111/nyas.13948. Epub 2018 Aug 7.

  PMID: 30085354 BACKGROUND

• Bonnal J, Ozsancak C, Monnet F, Valery A, Prieur F, Auzou P. Neural Substrates for Hand and Shoulder Movement in Healthy Adults: A Functional near Infrared Spectroscopy Study. Brain Topogr. 2023 Jul;36(4):447-458. doi: 10.1007/s10548-023-00972-x. Epub 2023 May 18.

  PMID: 37202647 DERIVED

Study Officials

• Julien BONNAL

  CHR d'Orléans

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 11, 2023
• First Posted: January 20, 2023
• Study Start: June 25, 2020
• Primary Completion: July 16, 2020
• Study Completion: July 16, 2020
• Last Updated: January 23, 2023

Record last verified: 2023-01

Locations

FR (1)