Energy Balance in Extreme Environments: Finding the EI Limit

NCT05773469 | Completed

• 1 other identifier: 595711
• Study Type: observational
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

This project is feasibility study looking at extreme exercise and possible diet intervention study to counter muscle and weight loss during a 2 person Greenland Ski Traverse in April 2023. By increasing energy intake to above the currently theoretical capacity (2.5 x RMR) the aim is to test a method to find out if there is a maximum to energy intake and whether energy deficit can be minimised; weight loss attenuated, and whether muscle can be preserved. If not, what are the likely adaptive mechanisms and use this to inform future work on dietary interventions

Conditions

Energy Expenditure; Atrophy, Muscular; Energy Intake

Keywords

polar; ultra endurance; doubly labelled water; energy expenditure; energy intake; limit

Outcome Measures

Primary Outcomes (1)

• body mass loss

  total amount of weight lost

  4 weeks

Secondary Outcomes (2)

• muscle loss

  4 weeks

• energy deficit

  4 weeks

Interventions

Exercise OTHER

Ski traverse of Greenland polar Icecap

Nutrition OTHER

Maximising energy intake by consuming over the theoretical 2.4 x RMR

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

2 persons undertaking a ski traverse across Greenland April - May 2023. 1 male and 1 female

You may qualify if:

• \*Partaking in ski traverse across Greenland April - May 2023

You may not qualify if:

• No neurological, neuromuscular, or musculoskeletal disorders that could impair the quality of the muscle. eg. CP, muscular dystrophy or SCI
• Not pregnant

Sponsors & Collaborators

• University of Exeter: lead

Study Sites (1)

University

Exeter, Devon, EX2 4TH, United Kingdom

Location

MeSH Terms

Conditions

Muscular Atrophy

Interventions

Exercise; Nutritional Status

Condition Hierarchy (Ancestors)

Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Health Status; Demography; Population Characteristics

Study Officials

• Francis Stephens

  University of Exeter

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 6, 2023
• First Posted: March 17, 2023
• Study Start: February 28, 2023
• Primary Completion: May 25, 2023
• Study Completion: November 26, 2023
• Last Updated: January 11, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)