Glycogen and Appetite

NCT05417659 | Completed

• 1 other identifier: EIRA1-7142
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is the outcome of chronic excessive energy intake and reduced energy expenditure leading to energy imbalance. It is a risk factor for many preventable diseases such as metabolic disease and its consequences such as type 2 diabetes and cardiovascular disease. Sedentary adults have been shown to have an increased appetite in excess of energy requirements and adults who are more active are able to better regulate energy intake. It is thought that carbohydrate availability and specifically hepatic glycogen utilisation during exercise is a regulator of appetite. However, the majority of research so far does not support this theory, potentially due to research not examining the tissue-specific link between glycogen use and appetite. The aim of this study is to assess whether altering substrate utilisation during exercise by suppressing lipolysis influences GLP-1 levels and caloric intake post exercise. Additionally, the study will explore if there is a tissue specific link between substrate utilisation and post exercise energy intake and examine potential sex differences.

Conditions

Energy Intake

Outcome Measures

Primary Outcomes (1)

• Difference in ad libitum energy intake

  Difference between ad libitum energy intake (kcal) post exercise between trials

  2 hours post exercise

Other Outcomes (13)

• Change in plasma GLP-1 concentrations post exercise

  2 hours

• Change in plasma leptin concentrations post exercise

  2 hours

• Change in plasma insulin concentrations during exercise

  1 hour

Study Arms (3)

Control

PLACEBO COMPARATOR

A placebo drink to be consumed 1 hour prior to exercise and every 15 minutes during exercise and placebo tablets to be consumed 30 minutes prior to exercise, at the onset of exercise and 30 minutes into exercise.

Other: Placebo

Exercise plus carbohydrate

ACTIVE COMPARATOR

A high carbohydrate drink (1.6g/kg) to be consumed 1 hour prior to exercise and further drinks (0.2g/kg) every 15 minutes during exercise.

Dietary Supplement: Exercise plus carbohydrate

Exercise plus niacin

EXPERIMENTAL

A dose of niacin (10mg/kg) to be consumed 30 minutes prior to exercise and two further doses (5mg/kg) at the onset of exercise and 30 minutes into exercise.

Dietary Supplement: Exercise plus niacin

Interventions

Exercise plus carbohydrate DIETARY_SUPPLEMENT

A high carbohydrate drink to be consumed 1 hour prior to exercise and every 15 minutes during exercise.

Exercise plus carbohydrate

Exercise plus niacin DIETARY_SUPPLEMENT

A dose of niacin to be consumed 30 minutes prior to exercise, at onset of exercise and 30 minutes into exercise.

Exercise plus niacin

Placebo OTHER

A placebo drink to be consumed 1 hour prior to exercise and every 15 minutes during exercise and placebo tablets to be consumed 30 minutes prior to exercise, at the onset of exercise and 30 minutes into exercise.

Control

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males aged 18-60 and premenopausal women
• Physically active (at least 30 minutes of exercise 3 times a week)
• Body mass index 18.0-30.0 kg·m-2

You may not qualify if:

• Weight instability (\>5kg change in body mass over last 6 months)
• Restrained eater (e.g. limiting food intake, calorie counting)
• Current smoker
• Aversion or allergy to test meal foods
• Pregnant or lactating
• Amenorrhoea in women
• Any medical condition or medication that could introduce bias into the study (e.g., diabetes, CVD, lipid or glucose metabolism altering medications)
• Any cardiopulmonary condition prohibiting exercise testing
• Any contraindication to niacin or aspirin (e.g., diabetes, gout, clotting disorders, allergy to non-steroidal anti-inflammatory drugs)

Sponsors & Collaborators

• University of Bath: lead

Study Sites (1)

Department for Health, University of Bath

Bath, BA2 7AY, United Kingdom

Location

MeSH Terms

Interventions

Exercise; Carbohydrates; Niacin

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Nicotinic Acids; Acids, Heterocyclic; Heterocyclic Compounds; Pyridines; Heterocyclic Compounds, 1-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Student

Study Record Dates

• First Submitted: May 17, 2022
• First Posted: June 14, 2022
• Study Start: October 10, 2022
• Primary Completion: March 15, 2024
• Study Completion: August 30, 2024
• Last Updated: March 27, 2025

Record last verified: 2023-10

Locations

GB (1)