Acute Effects of Cricket Fast Bowling on Bone Turnover and Signaling Markers

NCT07260318 | Enrolling By Invitation

• 1 other identifier: 11201
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to investigate the acute effects of cricket fast bowling on the bone turnover and signaling markers in healthy young males. The main question aims to answer: • Does a single bout acute fast bowling change serum C-terminal telopeptide of type I collagen (CTX-I) and other bone turnover and signaling markers levels? Participants complete both the bowling and control trials, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 2-hour post bowling/rest.

Conditions

Health Adults

Keywords

Cricket; Fast bowling; Bone turnover; Stress injuries

Outcome Measures

Primary Outcomes (1)

• Serum C-terminal telopeptide of type I collagen (CTX-I) concentration

  Serum CTX-I concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).

  Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.

Secondary Outcomes (7)

• Serum N-terminal propeptide of type I collagen (PINP) concentration

  Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.

• Serum parathyroid hormone (PTH) concentration

  Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.

• Serum sclerostin concentration

  Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.

• Serum dickkopf Wnt signaling pathway inhibitor 1 (DKK1) concentration

  Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.

• Serum osteoprotegerin (OPG) concentration

  Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.

Study Arms (2)

Arm Bowling + Control

EXPERIMENTAL

Participants first perform the bowling trial, followed by the control trial, with a minimum interval of one week between the two trials.

Behavioral: Exercise

Arm Control + Bowling

EXPERIMENTAL

Participants first perform the control trial, followed by the bowling trial, with a minimum interval of one week between the two trials.

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

During the bowling trial, participants perform 8 sets of 6 deliveries (bowl at match intensity throughout), followed by 2-hour rest. Each set is interspersed by a 3-minute randomized fielding simulation. During the control trial, participants rest throughout instead of bowling.

Arm Bowling + Control; Arm Control + Bowling

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male
• Aged 18 - 30
• Cricket fast bowlers (a ball speed of \~100kmh) playing for a university team or above, such as British Universities and Colleges Sport (BUCS) or University Centre of Cricketing Excellence (UCCE)
• Injury free for the last 3 months

You may not qualify if:

• Diagnosed with any disease or use of any medication that affects bone turnover
• Fracture experienced within the previous year/season

Sponsors & Collaborators

• Loughborough University: lead

Study Sites (1)

Loughborough Univeristy

Loughborough, Leicestershire, LE11 3TU, United Kingdom

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Katherine Brooke-Wavell

  Loughborough University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: December 3, 2025
• Study Start: February 20, 2023
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: December 3, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)