Study on the Development of Neonatal Cerebral Blood Flow Based on Ultrafast Ultrasound Doppler Imaging

NCT05761548 | Unknown

• 1 other identifier: M2022211
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Recently, with the development of perinatal medicine in China, the establishment of neonatal intensive care unit (NICU) and the improvement of respiratory support technology, the survival rate of preterm and term neonates has been significantly improved. However, the brain development of preterm neonates is incomplete compared with that of full-term neonates. Therefore, during the extrauterine cultivation of preterm neonates, clinical intervention should be carried out according to their brain development to achieve the same development status as that of full-term neonates. There are many clinical inspection methods to monitor the brain development of preterm neonates, such as EEG, functional near-infrared spectroscopy imaging, etc. However, these technologies cannot assess the brain development of premature infants systematically and completely. Because of the existence of neurovascular coupling, brain function and cerebral blood flow are closely related, so the detection of cerebral blood flow can reflect brain development and brain function. Ultrafast ultrasound power Doppler imaging technology is an emerging, real-time, high-resolution microvascular imaging technology. In this study, we first used ultrafast ultrasound power Doppler imaging technology to image the cerebral blood flow of preterm neonates at different gestational ages to evaluate the development of cerebral blood flow of preterm and term neonates and provide guidance for the clinical intervention of preterm neonates.

Conditions

Premature Birth

Outcome Measures

Primary Outcomes (2)

• Intrauterine cerebral blood flow development of neonates

  30 min

• Extrauterine cerebral blood flow development of neonates

  30 min

Study Arms (2)

mature

Diagnostic Test: ultrafast ultrasound power Doppler imaging

preterm

Diagnostic Test: ultrafast ultrasound power Doppler imaging

Interventions

ultrafast ultrasound power Doppler imaging DIAGNOSTIC_TEST

ultrafast ultrasound power Doppler imaging for neonatal brain microvessels

mature; preterm

Eligibility Criteria

• Age: 24 Weeks - 40 Weeks
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

From May 2022 to May 2023, newborns hospitalized in neonatal and NICU wards in the Peking University Third Hospital.

You may qualify if:

• neonates without cerebral diseases

You may not qualify if:

• neonates with cerebral diseases

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

RECRUITING

MeSH Terms

Conditions

Premature Birth

Condition Hierarchy (Ancestors)

Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate chief physician

Study Record Dates

• First Submitted: February 27, 2023
• First Posted: March 9, 2023
• Study Start: May 19, 2022
• Primary Completion: May 15, 2023
• Study Completion: July 1, 2023
• Last Updated: March 9, 2023

Record last verified: 2023-02

Locations

CN (1)