REBOUND PAIN AFTER PERIPHERAL NERVE BLOCKS

NCT05635383 | Completed

• 1 other identifier: 9.5.2022 137/01
• Study Type: observational
• Target: 386
• Locations: 1 country
• Sites: 2

Brief Summary

In recent years, the use of regional anesthesia techniques as part of multimodal analgesia strategies to maximize pain control in patients has reduced opioid requirements and promoted early mobility and rehabilitation in the perioperative period. Regional anesthesia has benefits, mainly peripheral nerve blocks (PNB), muscle relaxation, and postoperative analgesia, thus allowing for control of postoperative pain and early discharge from the hospital. In addition, using PNB techniques provides: Hemodynamic stability. Reduced need for a post-anesthetic care unit (PACU). Reduced unplanned hospitalization for pain control. Less airway management. Reduced incidence of opioid-related adverse events. Greater patient satisfaction The main feature of rebound pain is that it is severe pain, within 8-24 hours after PNB. It usually remains severe for 2-6 hours, but the subsequent pain trajectory is consistent with the recovery process expected at surgical intervention. Therefore, rebound pain is temporary and different from persistent post-surgical pain (PPSP). Rebound pain often occurs at night. However, this is probably related to the 8 to 12-hour duration of most single-injection PNBs and the completion of most elective surgeries during daylight hours.

Conditions

Pain; Block

Keywords

REBOUND PAIN; PERIPHERAL NERVE BLOCKS; analgesia

Outcome Measures

Primary Outcomes (1)

• incidence of rebound pain

  Rebound pain-defined as transient acute postoperative pain within 12-24hrs that ensues following resolution of sensory blocked.

  perioperative period

Secondary Outcomes (1)

• rebound pain risk factors

  perioperative period

Interventions

PERIPHERAL NERVE BLOCK OTHER

Observation of rebound pain after peripheral nerve block application

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged \>18 years who underwent orthopedic surgery with the peripheral nerve block will be included in the study.

You may qualify if:

• Patients aged \>18 years who underwent orthopedic surgery with the peripheral nerve block

You may not qualify if:

• Patients who did not want to participate in the study
• dementia
• severe psychiatric or cognitive dysfunction
• coagulopathy
• neuropathic disorder
• local anesthetic allergy
• serious heart-lung disease
• chronic opioid use

Sponsors & Collaborators

• Diskapi Yildirim Beyazit Education and Research Hospital: lead

Study Sites (2)

University of Medical Science, Yıldırım Beyazıt Training and Research Hospital

Ankara, 06000, Turkey (Türkiye)

Location

Diskapi Yildirim Beyazit Education and Research Hospital

Ankara, Turkey (Türkiye)

Location

Related Publications (3)

• Williams BA, Bottegal MT, Kentor ML, Irrgang JJ, Williams JP. Rebound pain scores as a function of femoral nerve block duration after anterior cruciate ligament reconstruction: retrospective analysis of a prospective, randomized clinical trial. Reg Anesth Pain Med. 2007 May-Jun;32(3):186-92. doi: 10.1016/j.rapm.2006.10.011.

  PMID: 17543812 BACKGROUND

• Gramke HF, de Rijke JM, van Kleef M, Kessels AG, Peters ML, Sommer M, Marcus MA. Predictive factors of postoperative pain after day-case surgery. Clin J Pain. 2009 Jul-Aug;25(6):455-60. doi: 10.1097/AJP.0b013e31819a6e34.

  PMID: 19542791 BACKGROUND

• Lavand'homme P. Rebound pain after regional anesthesia in the ambulatory patient. Curr Opin Anaesthesiol. 2018 Dec;31(6):679-684. doi: 10.1097/ACO.0000000000000651.

  PMID: 30124544 RESULT

MeSH Terms

Conditions

Pain; Bites and Stings; Agnosia

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Poisoning; Chemically-Induced Disorders; Wounds and Injuries; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 23, 2022
• First Posted: December 2, 2022
• Study Start: August 1, 2022
• Primary Completion: January 1, 2024
• Study Completion: March 12, 2024
• Last Updated: March 28, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (2)