Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement
1 other identifier
observational
178,214
1 country
1
Brief Summary
Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function. However, their impact on other outcomes is poorly described. Therefore, this comparative effectiveness study will estimate the independent association between nerve blocks and health outcomes after knee replacement surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2002
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2002
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2014
CompletedFirst Submitted
Initial submission to the registry
April 13, 2016
CompletedFirst Posted
Study publicly available on registry
April 19, 2016
CompletedApril 19, 2016
April 1, 2016
11.9 years
April 13, 2016
April 18, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Hospital length of stay
Determined from the Canadian Institute for Health Information Discharge Abstract Database record for the index hospitalization
Day of surgery to day of discharge, or up to 365 days, whichever comes first
Secondary Outcomes (3)
Hospital readmission
The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any readmission in this time period will be considered an event.
In-hospital fall
hospital admission
Emergency department visit
The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any emergency department visit in this time period will be considered an event.
Other Outcomes (1)
All cause mortality
Day of surgery to 30 days after surgery
Study Arms (2)
Peripheral nerve block
Intervention arm. Participants who receive a peripheral nerve block identified through submission of an appropriate physician billing code
No peripheral nerve block
Control arm. Participants who do not receive a peripheral nerve block identified through lack of a submission of an appropriate physician billing code
Interventions
A physician billing code for deposition of a local anesthetic solution around an anatomically defined nerve or nerve plexus
Eligibility Criteria
All adults having their first total knee replacement during the study period
You may qualify if:
- first primary total knee replacement during the study period
You may not qualify if:
- Revision arthroplasty
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ottawa Hospital Research Institute
Ottawa, Ontario, K1Y4E9, Canada
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Scientist
Study Record Dates
First Submitted
April 13, 2016
First Posted
April 19, 2016
Study Start
April 1, 2002
Primary Completion
March 1, 2014
Study Completion
March 1, 2014
Last Updated
April 19, 2016
Record last verified: 2016-04
Data Sharing
- IPD Sharing
- Will not share