Comparison of Perioperative Analgesic Efficacy of Femoral Nerve Block, Adductor Canal Block and 4in1 Block

NCT05643040 | Completed

• 1 other identifier: 06/06/2022 139/13
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Central neuraxial and regional anesthesia and analgesia techniques significantly reduce perioperative morbidity and mortality in the knee and below-knee surgeries.Nerve blocks appear to have better analgesic efficacy compared to placebo or patient-controlled analgesia (PCA). In addition, opioid-related side effects such as postoperative nausea, vomiting, pruritus, sedation, and respiratory depression are less. Therefore, interest in regional blocks such as femoral, sciatic, adductor, combined femoral, and sciatic is increasing. The knee joint is innervated by various nerves (genicular nerves) from the femoral, obturator, and sciatic nerves, and a comprehensive but simple technique is needed for postoperative analgesia. Complete and comprehensive postoperative analgesia was possible with this block, a simple single injection technique. The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block, and 4in1 block in patients who will undergo knee surgery.

Conditions

Block; Analgesia

Keywords

4 in 1 block; femoral block; adductor canal block

Outcome Measures

Primary Outcomes (1)

• intraoperative analgesia efficacy

  The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.

  perioperative period

Secondary Outcomes (1)

• postoperative analgesia efficacy

  perioperative period

Study Arms (3)

femoral nerve block

EXPERIMENTAL

To evaluate the intraoperative analgesia effectiveness of femoral nerve block in patients who will have knee surgery.

Other: femoral nerve block

adductor canal block

EXPERIMENTAL

To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery.

Other: adductor canal block

4in1 block

EXPERIMENTAL

To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery.

Other: 4in1 block

Interventions

femoral nerve block OTHER

To evaluate the intraoperative analgesia effectiveness of femoral block in patients who will have knee surgery.

femoral nerve block

adductor canal block OTHER

To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery.

adductor canal block

4in1 block OTHER

To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery.

4in1 block

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients between the ages of \>18
• undergone knee surgery
• American Society of Anesthesiologists (ASA) classification I-III group.

You may not qualify if:

• Patients who do not want to participate in the study coagulopathy peripheral neuropathy local anesthetic drug allergy chronic opioid users anticoagulant users pregnant patients

Sponsors & Collaborators

• Diskapi Yildirim Beyazit Education and Research Hospital: lead

Study Sites (1)

University of Medical Science, Yıldırım Beyazıt Training and Research Hospital

Ankara, 06000, Turkey (Türkiye)

Location

Related Publications (2)

• Rodgers A, Walker N, Schug S, McKee A, Kehlet H, van Zundert A, Sage D, Futter M, Saville G, Clark T, MacMahon S. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ. 2000 Dec 16;321(7275):1493. doi: 10.1136/bmj.321.7275.1493.

  PMID: 11118174 BACKGROUND

• Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for total knee arthroplasty: Ultrasound guided single injection modified 4 in 1 block. J Anaesthesiol Clin Pharmacol. 2020 Apr-Jun;36(2):261-264. doi: 10.4103/joacp.JOACP_260_19. Epub 2020 Jun 15.

  PMID: 33013045 BACKGROUND

MeSH Terms

Conditions

Bites and Stings; Agnosia

Condition Hierarchy (Ancestors)

Poisoning; Chemically-Induced Disorders; Wounds and Injuries; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Diskapi Yildirim Beyazit Education and Research Hospital

Model Details: Group I: Femoral nerve block Group II: Adductor canal block Group III: 4in1 block

Study Record Dates

• First Submitted: November 23, 2022
• First Posted: December 8, 2022
• Study Start: September 1, 2022
• Primary Completion: June 20, 2025
• Study Completion: June 30, 2025
• Last Updated: July 3, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)