Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

NCT05628935 | Completed

• 1 other identifier: 2020-22/17
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.

Conditions

Inflammation; Anesthesia

Keywords

General Anesthesia; Neutrophil Lymphocyte Ratio; Peripheral Nerve Block

Outcome Measures

Primary Outcomes (1)

• Neutrophil/lymphocyte ratio

  Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block

  up to 24 hours after surgery

Secondary Outcomes (2)

• Platelet/lymphocyte ratio

  up to 24 hours after surgery

• Mean Platelet Volume

  up to 24 hours after surgery

Study Arms (2)

Group G

Patients Undergoing Forearm Surgery under general anesthesia

Group P

Patients Undergoing Forearm Surgery under peripheral nerve block

Procedure: peripheral nerve block

Interventions

peripheral nerve block PROCEDURE

local anesthetic application to the brachial plexus

Group P

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 18-65 years who have underwent forearm surgery

You may qualify if:

• Underwent forearm surgery
• Between aged 18-70
• Under general anesthesia or peripheral nerve block

You may not qualify if:

• acute infection
• morbid obesity
• chronic treatment with steroids or immunosuppressants
• recently received chemotherapy
• hepatic and renal dysfunction;
• chronic alcohol abusers
• Multiple trauma
• Patients with missing data in their files

Sponsors & Collaborators

• Zonguldak Bulent Ecevit University: lead

Study Sites (1)

Zonguldak Bülent Ecevit University Medicine Faculty

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: medical doctor

Study Record Dates

• First Submitted: November 17, 2022
• First Posted: November 29, 2022
• Study Start: January 1, 2018
• Primary Completion: November 1, 2020
• Study Completion: November 1, 2021
• Last Updated: November 29, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)