Short-term Sleep Restriction on Taste Preference and Perception

NCT05524701 | Unknown

• 1 other identifier: 200210063
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims is to investigate the effects of sleep restriction on sweet and fat taste perception and preference in both fasted and fed states. This is a randomised crossover trial with sleep restriction (4 hours per night for 2 nights) and normal sleep (at least 8 hours sleep for 2 nights) conditions, with a four-week washout period between conditions.

Conditions

Sleep Restriction; Normal Sleep

Outcome Measures

Primary Outcomes (4)

• Sweet Taste Preference

  Preference for sweetness will be assessed by providing participants with 5ml volumes of 5 sucrose solutions with concentrations 3%, 6%, 12%, 24% and 36% in random order. Preference for sweetness will be assessed by asking participants to rate the pleasantness of the solution on a VAS with anchors of 'not at all pleasant' and 'extremely pleasant'. To determine the preferred optimal sweetness, participants will be presented with pairs of 5 sucrose solutions and asked which solution they prefer. This will continue until the participants consistently choose a preference for a solution twice a row. A maximum of 10 trials will be conducted to assess preference. This assessment will be done fasted and fed state.

  0-4 weeks

• Sweet Taste Perception

  Perception of sweetness will be assessed by providing participants with 5ml volumes of 5 sucrose solutions with concentrations 3%, 6%, 12%, 24% and 36% in random order. The perception of sweetness will be measured via visual analogue scale (VAS) to rate the sweetness of the solution with anchors of 'not at all sweet' and 'extremely sweet'.

  0-4 weeks

• Fat Taste Preference

  Preference for fat taste will be assessed by providing participants with 5ml volumes 5 solutions with combinations with concentrations 3%, 6%, 12%, 24% and 36% fat (comprising skimmed milk and double cream mixes of different proportions) in random order. Preference for fat taste will be assessed by asking participants to rate pleasantness of the solution on a VAS with anchors of 'not at all' and 'extremely'. To determine the preferred optimal fat taste, participants will be presented with 5 pairs of milk and cream mix solutions and asked which solution they prefer. This will continue until the participants consistently choose a preference for one solution twice in a row. A maximum of 10 trials will be conducted to assess preference. This assessment will be done fasted and fed state.

  0-4 weeks

• Fat Taste Perception

  Perception and preference for fat will be assessed by providing participants with 5ml volumes 5 solutions with combinations with concentrations 3%, 6%, 12%, 24% and 36% fat (comprising skimmed milk and double cream mixes of different proportions) in random order. The perception of fat will be measured via a visual analogue scale (VAS) to rate the creaminess of solution with anchors of 'not at all' and 'extremely'.

  0-4 weeks

Secondary Outcomes (7)

• Food preference - explicit liking

  0-4 weeks

• Food preference - explicit wanting

  0-4 weeks

• Food reward - implicit wanting

  0-4 weeks

• Control of Eating Questionnaire - Craving control

  0-4 weeks

• Control of Eating Questionnaire - Craving for sweet

  0-4 weeks

Study Arms (2)

Sleep Restriction Condition

EXPERIMENTAL

Participants will be asked to restrict their sleep duration to a maximum of four hours per night (3 am to 7 am) for the two nights prior to the measurement day.

Behavioral: Sleep Restriction and Normal Sleep

Normal Sleep Condition

EXPERIMENTAL

Participants will be asked to sleep for at least eight hours per night (11 pm to 7 am) for two nights prior to the measurement day.

Behavioral: Sleep Restriction and Normal Sleep

Interventions

Sleep Restriction and Normal Sleep BEHAVIORAL

The intervention will consist of either sleep restriction (4 hours per night, 3 am to 7 am) or normal sleep (8 hours per night 11 pm to 7 am) for a duration of two nights.

Normal Sleep Condition; Sleep Restriction Condition

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years and above
• Self Reported sleep of \>7 hours a night

You may not qualify if:

• Dairy allergy
• Presence of any serious medical conditions which might influence sleep i.e cardiovascular diseases, diabetes, cancer, respiratory disease, other than mild asthma)
• History of bariatric surgery
• Taking any kind of medication which might affect regular sleep
• Taking any type of medication which might affect appetite
• Participating in any kind of dietary and/or weight loss programs
• Taking antidepressants
• Substance or alcohol abuse
• Shift work
• Currently having to wake up at night to care for another person
• Suffering from and/or receiving treatment for mental health conditions or sleep apnoea.

Sponsors & Collaborators

• University of Glasgow: lead

Study Sites (1)

University of Glasgow

Glasgow, G12 8QQ, United Kingdom

RECRUITING

Study Officials

• Jason Gill, PhD

  University of Glasgow

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jason Gill, PhD

CONTACT

141 330 2916; jason.gill@glasgow.ac.uk

Ayan Merchant, MSc.

CONTACT

141 330 2671; a.merchant.1@research.gla.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: A randomised crossover trial with one group undergoing two conditions- a sleep restriction condition and a normal sleep condition.

Study Record Dates

• First Submitted: August 29, 2022
• First Posted: September 1, 2022
• Study Start: September 1, 2022
• Primary Completion: February 28, 2023
• Study Completion: February 28, 2023
• Last Updated: September 1, 2022

Record last verified: 2022-08

Locations

GB (1)