Impact of a Sleep Debt in Middle-Aged and Older Adults

NCT00817700 | Completed

• 2 other identifiers: #13159A5P01AG011412
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

This project has 6 aims.

1. 1.To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
2. 2.To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
3. 3.To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
4. 4.To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
5. 5.To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
6. 6.To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.

Conditions

Sleep Restriction

Keywords

Sleep; young adults; middle-age adults; older adults

Outcome Measures

Primary Outcomes (1)

• Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery.

  Completion of 23 day study

Study Arms (2)

Normal (8 hours) sleep time

NO INTERVENTION

Subjects are studied under normal sleep time conditions.

Sleep restriction

EXPERIMENTAL

Sleep restriction to 4 hours of sleep per night. Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.

Other: Sleep restriction

Interventions

Sleep restriction OTHER

Sleep restriction.

Sleep restriction

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• normal weight
• healthy
• age 18-75 old

You may not qualify if:

• sleep disorder
• irregular life habits (shift workers, travelers)
• smokers
• on medication
• consumption of \> 2 alcohol or caffeinated beverages/day

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

The University of Chicago

Chicago, Illinois, 60637, United States

Location

Study Officials

• Eve Van Cauter, PhD

  University of Chicago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2009
• First Posted: January 6, 2009
• Study Start: April 1, 2005
• Primary Completion: November 1, 2007
• Study Completion: May 1, 2008
• Last Updated: January 11, 2017

Record last verified: 2017-01

Locations

US (1)