NCT05514535

Brief Summary

This study compares semaglutide, together with a lower dose of insulin glargine, to a higher dose of insulin glargine in participants with type 2 diabetes. The study looks at how well the study medicines control blood glucose levels. Participants will either get semaglutide together with a lower dose of insulin glargine or a higher dose of insulin glargine. The study will last for about 47 weeks (approximately 11 months). Participants will have 9 clinic visits, 15 phone/video calls and 1 home visit. Participants will be asked to wear a sensor that measures their blood sugar all the time in 2 periods of 10 days during the study.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
573

participants targeted

Target at P50-P75 for phase_3 diabetes-mellitus-type-2

Timeline
Completed

Started Aug 2022

Longer than P75 for phase_3 diabetes-mellitus-type-2

Geographic Reach
12 countries

239 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 22, 2022

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 24, 2022

Completed
5 days until next milestone

Study Start

First participant enrolled

August 29, 2022

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 5, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

April 9, 2025

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

May 11, 2026

Completed
Last Updated

May 11, 2026

Status Verified

April 1, 2026

Enrollment Period

2.5 years

First QC Date

August 22, 2022

Results QC Date

March 5, 2026

Last Update Submit

April 17, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Glycated Haemoglobin (HbA1c) [Noninferiority]

    Change in HbA1c (Noninferiority) from baseline (Week 0) to end of treatment (Week 40) were reported. Here noninferiority was assessed based on the clinically acceptable margin of 0.3%-point for the mean treatment difference in HbA1c.

    From baseline (week 0) to end of treatment (week 40)

Secondary Outcomes (13)

  • Change in Body Weight

    From baseline (week 0) to end of treatment (week 40)

  • Percentage Change in Daily Insulin Dose

    From baseline (week 0) to end of treatment (week 40)

  • Change in Glycated Haemoglobin (HbA1c ) [Superiority]

    From baseline (week 0) to end of treatment (week 40)

  • Score of Diabetes Treatment Satisfaction Questionnaire - Change Version (DTSQc)

    At end of treatment (week 40)

  • Number of Participants Achieving Insulin Dose = 0 Units/mL (U)

    At end of treatment (week 40)

  • +8 more secondary outcomes

Study Arms (2)

Insuline glargine U100 (reduced) + semaglutide

EXPERIMENTAL

Participants will initially receive 0.25 milligrams (mg) once-weekly semaglutide subcutaneously (s.c.) and the dose will be gradually escalated to 2 mg as an add-on to dose-reduced insulin glargine s.c. given once-daily. Insulin glargine U100 will be reduced by 10 U at the initiation of semaglutide and then again at each semaglutide dose escalation. Insulin glargine dose will be adjusted based on the mean of three pre-breakfast self-measured plasma glucose (SMPG) values (target SMPG: 4.4-7.2 millimoles per litre (mmol/L)).

Drug: SemaglutideDrug: Insuline glargine U100 (reduced)

Insuline glargine U100 (titrated)

ACTIVE COMPARATOR

Participants will receive titrated insuline glargine U100 s.c. once-daily. Insulin glargine U100 dose will be adjusted based on the mean of three pre-breakfast SMPG values (target SMPG: 4.4-7.2 mmol/L).

Drug: Insuline glargine U100 (titrated)

Interventions

Participants will receive titrated insulin glargine U100 s.c. once-daily up to 40 weeks. The dose will be adjusted based on the mean of three pre-breakfast SMPG values (target SMPG: 4.4-7.2 mmol/L).

Insuline glargine U100 (titrated)

Participants will receive once-weekly semaglutide s.c. for 40 weeks. Semaglutide 0.25 mg will be given at week 0 and then the dose will be escalated at weeks 4, 8 and 12 to 0.5 mg, 1 mg, 2 mg respectively.

Insuline glargine U100 (reduced) + semaglutide

Participants will receive insulin glargine U100 s.c. once-daily. Insulin glargine dose will be reduced by 10 U at initiation of semaglutide and then again at each semaglutide dose escalation up to 40 weeks. The dose will be adjusted based on the mean of three pre-breakfast SMPG values (target SMPG: 4.4-7.2 mmol/L).

Insuline glargine U100 (reduced) + semaglutide

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosed with Type 2 Diabetes Mellitus (T2D) mellitus greater than or equal to (\>=) 180 days before screening.
  • Glycated haemoglobin (HbA1c) of 7-10 percentage \[(53-86 millimoles per mole (mmol/mol)\] (both inclusive) as assessed by central laboratory on the day of screening.
  • Body mass index (BMI) greater than or equal to (\>=) 25 kilograms per meter square (kg/m\^2) on the day of screening.
  • Stable daily dose(s) greater than or equal to (\>=) 90 days before screening of any of the following anti-diabetic drugs or combination regimens:
  • Any metformin formulations greater than or equal to (\>=) 1500 milligrams (mg) or maximum tolerated or effective dose.
  • Any metformin combination formulation greater than or equal to (\>=) 1500 mg or maximum tolerated or effective dose.
  • The treatment can be with or without sodium glucose cotransporter 2 (SGLT-2) inhibitors.
  • Treated with a once daily basal insulin (e.g. insulin glargine Unit 100 or U300, neutral protamine hagedorn (NPH) insulin, insulin detemir, insulin degludec) less than or equal to (\<=) 40 units/day (U/day) for greater than or equal to (\>=) 90 days before screening. Short-term bolus insulin treatment for a maximum of 14 days before screening is allowed.

You may not qualify if:

  • Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
  • Potentially missed diagnosis of Type 1 diabetes (T1D) or latent autoimmune diabetes in adults (LADA) verified by C-peptide less than 0.26 nanomoles per litre (nmol/L) (or 260 picomoles per liter \[pmol/L\] \[0.78 nanograms per millilitre {ng/mL}\]) or antibodies to glutamic acid decarboxylase (anti-GAD) greater than 5 units/millilitre, as measured by the central laboratory at screening.
  • Presence or history of pancreatitis (acute or chronic).
  • Renal impairment measured as estimated Glomerular Filtration Rate (eGFR) value of less than 30 millilitre per minute per 1.73 meter square at screening as defined by Kidney Disease: Improving Global Outcomes (KDIGO) 2012 classification.
  • Any episodes of diabetic ketoacidosis within 90 days before screening.
  • Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire question 8.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (239)

Shoals Primary Care

Sheffield, Alabama, 35660, United States

Location

Lenzmeier Fam Med CCT Research

Glendale, Arizona, 85308, United States

Location

Synexus Clinical Research US, Inc./Desert Clinical Research,

Mesa, Arizona, 85213, United States

Location

OneLife Direct Care Inc.

Searcy, Arkansas, 72143, United States

Location

Unity Health-Searcy Medical Center

Searcy, Arkansas, 72143, United States

Location

San Fernando Valley Hlth Inst, LLC

Canoga Park, California, 91304, United States

Location

Velocity Clin Res-Chula Vista

Chula Vista, California, 91911, United States

Location

John Muir Physicians Network

Concord, California, 94520, United States

Location

Valley Research

Fresno, California, 93720, United States

Location

Ascada Research

Fullerton, California, 92835, United States

Location

Providence Medical Foundation

Fullerton, California, 92835, United States

Location

Velocity Clinical Research Huntington Park

Huntington Park, California, 90255, United States

Location

Scripps Memorial Hospital La Jolla

La Jolla, California, 92037, United States

Location

Velocity Clin Res San Diego

La Mesa, California, 91942, United States

Location

First Valley Medical Group

Lancaster, California, 93534, United States

Location

Loma Linda Univ Hlth Cr Endo

Loma Linda, California, 92354, United States

Location

Torrance Clin Res Inst, Inc.

Lomita, California, 90717, United States

Location

NRC Research Institute

Los Angeles, California, 90015, United States

Location

Downtown LA Res Ctr. Inc.

Los Angeles, California, 90017, United States

Location

Velocity Clin Res Los Angeles

Los Angeles, California, 90017, United States

Location

Valley Clinical Trials, Inc.

Northridge, California, 91325, United States

Location

San Diego Family Care_San Diego

San Diego, California, 92111, United States

Location

Wetlin Research Associates, Inc.

San Diego, California, 92120, United States

Location

University Clin Investigators

Tustin, California, 92780, United States

Location

Velocity Clin Res, Denver

Denver, Colorado, 80209, United States

Location

Chase Medical Research LLC

Waterbury, Connecticut, 06708, United States

Location

Indago Research & Health Center Inc.

Hialeah, Florida, 33012, United States

Location

Encore Medical Research LLC

Hollywood, Florida, 33024, United States

Location

Northeast Res Inst. Inc.

Jacksonville, Florida, 32204, United States

Location

Jacksonville Ctr For Clin Res

Jacksonville, Florida, 32216, United States

Location

Care-Partners-Clinical-Research, LLC

Jacksonville, Florida, 32277, United States

Location

Suncoast Research Group, LLC

Miami, Florida, 33135, United States

Location

New Horizon Research Center

Miami, Florida, 33165, United States

Location

Elite Research Center

Miami, Florida, 33169, United States

Location

Diverse Clinical Research Miami

Miami, Florida, 33175, United States

Location

Reyes Clinical Research, Inc

Miami, Florida, 33175, United States

Location

International Research Associates, LLC_Miami

Miami, Florida, 33183, United States

Location

South Broward Research LLC

Miramar, Florida, 33027, United States

Location

Suncoast Clin Res Port Richey

New Port Richey, Florida, 34652, United States

Location

Suncoast Clinical Research, Inc._New Port Richey

New Port Richey, Florida, 34652, United States

Location

Renstar Medical Research

Ocala, Florida, 34470, United States

Location

Clinical Research Trials of Florida

Tampa, Florida, 33607, United States

Location

CVS Store Number: 7689

Atlanta, Georgia, 30329-4015, United States

Location

East Coast Institute for Res

Canton, Georgia, 30114, United States

Location

Coastal Heritage Clinical Research

Hinesville, Georgia, 31313, United States

Location

East Coast Institute for Res

Macon, Georgia, 31210, United States

Location

Endocrine Research Solutions

Roswell, Georgia, 30076, United States

Location

CVS Store Number: 05520

Savannah, Georgia, 31405-6901, United States

Location

Solaris Clinical Research

Meridian, Idaho, 83646, United States

Location

Cedar-Crosse Research Center

Chicago, Illinois, 60607, United States

Location

WellNow Urgent Care

Chicago, Illinois, 60661, United States

Location

Brengle Family Medicine

Indianapolis, Indiana, 46260, United States

Location

West Broadway Clinic

Council Bluffs, Iowa, 51501, United States

Location

Iowa Diab & Endo Res Center

West Des Moines, Iowa, 50265, United States

Location

Iowa Diab & Endo Res Center

West Des Moines, Iowa, 50266, United States

Location

Cotton O'Neil Diab & Endo Ctr

Topeka, Kansas, 66606, United States

Location

The Research Group of Lexington LLC

Lexington, Kentucky, 40503, United States

Location

L-MARC Research Center

Louisville, Kentucky, 40213, United States

Location

Arthritis And Diabetes Clinic, Inc.

Monroe, Louisiana, 71203, United States

Location

AMR New Orleans

New Orleans, Louisiana, 70119, United States

Location

Ileana J. Tandron, MD APMC (a private medical office)

Slidell, Louisiana, 70461, United States

Location

MedStar Hlth Res Institute

Hyattsville, Maryland, 20782, United States

Location

Endo And Metab Cons

Rockville, Maryland, 20852, United States

Location

Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Joslin Diabetes Center

Boston, Massachusetts, 02215, United States

Location

Northern Pines Hlth Ctr, PC

Buckley, Michigan, 49620, United States

Location

Henry Ford Health System

Detroit, Michigan, 48202, United States

Location

Elite Research Center

Flint, Michigan, 48532, United States

Location

Arcturus HC PLC Troy Med Res

Troy, Michigan, 48098, United States

Location

StudyMetrix Research LLC

City of Saint Peters, Missouri, 63303, United States

Location

Mercury Str Med Grp, PLLC

Butte, Montana, 59701, United States

Location

Clinical Research Advantage, Inc./Skyline Medical Center, PC

Elkhorn, Nebraska, 68022, United States

Location

Methodist Physicians Clinic

Fremont, Nebraska, 68025, United States

Location

Velocity Clin Res, Norfolk

Norfolk, Nebraska, 68701, United States

Location

Midwest Regional Health Services

Omaha, Nebraska, 68144, United States

Location

Univ of Nebraska Medical CTR

Omaha, Nebraska, 68198-3020, United States

Location

Palm Research Center Inc-Vegas

Las Vegas, Nevada, 89128, United States

Location

Southern New Hampshire Diabetes and Endocrinology

Nashua, New Hampshire, 03060, United States

Location

Premier Research Inc.

Trenton, New Jersey, 08611, United States

Location

AMC Community Endocrinology

Albany, New York, 12203, United States

Location

Dr. Alexander Perkelvald

Brooklyn, New York, 11229, United States

Location

Mid Hudson Med Res-New Windsor

New Windsor, New York, 12553, United States

Location

Great Lakes Medical Research

Westfield, New York, 14787, United States

Location

University of North Carolina Medical Center

Chapel Hill, North Carolina, 27514, United States

Location

Physicians East Endocrinology

Greenville, North Carolina, 27834, United States

Location

Carteret Medical Group

Morehead City, North Carolina, 28557, United States

Location

Centricity Rsrch MHCity Multi

Morehead City, North Carolina, 28557, United States

Location

Lillestol Research LLC

Fargo, North Dakota, 58104, United States

Location

Velocity Clin Res Cleveland

Beachwood, Ohio, 44122, United States

Location

Diab & Endo Assoc of Stark Co

Canton, Ohio, 44718, United States

Location

Velocity Clin Res_Cincinnati

Cincinnati, Ohio, 45219, United States

Location

Albert J Weisbrot

Mason, Ohio, 45040, United States

Location

Advanced Med Res Maumee

Maumee, Ohio, 43537, United States

Location

University of Toledo Medical Center

Toledo, Ohio, 43614, United States

Location

University of Toledo_Toledo

Toledo, Ohio, 43614, United States

Location

Intend Research

Norman, Oklahoma, 73069, United States

Location

Lynn Institute of Norman

Norman, Oklahoma, 73069, United States

Location

Velocity Clinical Res Medford

Medford, Oregon, 97504, United States

Location

Heritage Valley Multispeciality Group Inc

Beaver, Pennsylvania, 15009, United States

Location

Richard M Kastelic MD Assoc

Johnstown, Pennsylvania, 15905, United States

Location

Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States

Location

Preferred Primary Care Physicians, Inc.

Uniontown, Pennsylvania, 15401, United States

Location

Carolina Health Specialists

Myrtle Beach, South Carolina, 29572, United States

Location

Palmetto Clinical Research

Summerville, South Carolina, 29485, United States

Location

Chattanooga Medical Research, LLC

Chattanooga, Tennessee, 37404, United States

Location

Univ Diab & Endo Consultants

Chattanooga, Tennessee, 37411, United States

Location

Jackson Clinic

Jackson, Tennessee, 38305, United States

Location

Holston Medical Group

Kingsport, Tennessee, 37660, United States

Location

Accellacare US Inc., d/b/a Accellacare of Knoxville

Knoxville, Tennessee, 37938, United States

Location

Clinical Neuroscience Solutions

Memphis, Tennessee, 38119, United States

Location

Amarillo Med Spec LLP

Amarillo, Texas, 79106, United States

Location

Arlington Family Res. Ctr Inc

Arlington, Texas, 76012-4637, United States

Location

Central Texas Clinical Research

Austin, Texas, 78705, United States

Location

Velocity Clin Res Austin

Cedar Park, Texas, 78613, United States

Location

Thyroid Endocrinology & Diabetes PA

Dallas, Texas, 75208, United States

Location

Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States

Location

Academy of Diabetes, T&E

El Paso, Texas, 79935, United States

Location

Diabetes and Thyroid Ctr of FW

Fort Worth, Texas, 76132, United States

Location

Gonzalez Family & Occupational Medicine

Houston, Texas, 77029, United States

Location

JCCT- Juno NW Houston

Houston, Texas, 77040, United States

Location

Houston Institute for Clinical Research

Houston, Texas, 77074, United States

Location

Protenium Clinical Research

Hurst, Texas, 76054, United States

Location

DCOL Ctr for Clin Res

Longview, Texas, 75605, United States

Location

Tekton Research

McKinney, Texas, 75069, United States

Location

Clinical Investigations Of Texas

Plano, Texas, 75075, United States

Location

San Antonio Prem Int Med

San Antonio, Texas, 78220, United States

Location

Briggs Clinical Research, LLC

San Antonio, Texas, 78224, United States

Location

Diabetes Glandular Diseases Clinic

San Antonio, Texas, 78229, United States

Location

VIP Trials

San Antonio, Texas, 78230, United States

Location

Diabetes Glandular Diseases Clinic

San Antonio, Texas, 78240, United States

Location

Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States

Location

Med-Olam Clinical Reseach LLC

Sugar Land, Texas, 77479, United States

Location

Hillcrest Family Health Center

Waco, Texas, 76708, United States

Location

Advanced Research Institute

Ogden, Utah, 84405, United States

Location

South Ogden Family Medicine/ CCT Research

Ogden, Utah, 84405, United States

Location

Olympus Family Medicine

Salt Lake City, Utah, 84117, United States

Location

Chrysalis Clinical Research

St. George, Utah, 84790, United States

Location

Velocity Clin Res-Salt Lk City

West Jordan, Utah, 84088, United States

Location

Virginia Endo Res, LLC

Chesapeake, Virginia, 23321, United States

Location

York Clinical Research LLC

Norfolk, Virginia, 23504, United States

Location

CVS Store Number: 01396

Reston, Virginia, 20191-4327, United States

Location

CVS Store Number: 1537

Richmond, Virginia, 23230-3005, United States

Location

Amherst Family Practice P.C.

Winchester, Virginia, 22601, United States

Location

WVU Medicine

Morgantown, West Virginia, 26506, United States

Location

Prevea Health

Green Bay, Wisconsin, 54303, United States

Location

EDUMED s.r.o.

Náchod, 547 01, Czechia

Location

Diahelp - diabetologie

Pardubice, 530 02, Czechia

Location

MUDr. Jitka Zemanova - diabetologie a interna, s.r.o.

Plzen - Vychodni Predmesti, 326 00, Czechia

Location

Diabet2 s.r.o.

Prague, 110 00, Czechia

Location

MUDr. Michala Pelikanova

Prague, 140 00, Czechia

Location

ResTrial s.r.o.

Prague, 18100, Czechia

Location

University Hospital of Athens ATTIKON

Athens, Attica, 12462, Greece

Location

University Hospital of Alexandroupolis

Alexandroupoli, 68100, Greece

Location

"Laiko" General Hospital of Athens

Athens, 11527, Greece

Location

Alexandra General Hospital, Therapeutic Clinic

Athens, 11528, Greece

Location

Alexandra General Hospital, Therapeutic Clinic

Athens, GR-11528, Greece

Location

Geniko Nosokomeio Nikaias Peiraia Ag. Panteleimon Geniko Nosokomeio Dytikis Attikis I - Diabetes Department

Nikaia, GR-18454, Greece

Location

Geniko Nosokomeio Peiraia Tzaneio

Piraeus, 18536, Greece

Location

AHEPA General University Hospital

Thessaloniki, 54636, Greece

Location

EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes

Thessaloniki, 54645, Greece

Location

"Thermi" Private Hosital

Thessaloniki, 57001, Greece

Location

General Hospital of Thessaloniki "G.Papanikolaou"

Thessaloniki, 57010, Greece

Location

"Thermi" Private Hosital

Thessaloniki, GR-57001, Greece

Location

A.O.U. Università Studi della Campania "Luigi Vanvitelli"

Naples, Campania, 80138, Italy

Location

Ospedale Santa Maria Goretti - UOD Diabetologia

Latina, LT, 04100, Italy

Location

Azienda Unita' Sanitaria Locale Toscana Nord Ovest - Cittadella della Salute Campo di Marte

Lucca, LU, 55100, Italy

Location

Istituto Scientifico San Raffaele

Milan, MI, 20132, Italy

Location

Policlinico Umberto I Seconda Clinica Medica

Roma, RM, 00161, Italy

Location

Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia

Perugia, Umbria, 06129, Italy

Location

Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, 24127, Italy

Location

Policlinico Mater Domini Università di Catanzaro

Catanzaro, 88100, Italy

Location

ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari

Montichiari, 25018, Italy

Location

A.O.U. Università Studi della Campania "Luigi Vanvitelli"

Naples, 80138, Italy

Location

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di scienze Mediche e Chirurgiche

Rome, 00168, Italy

Location

ULS De Matosinhos E.P.E.- Hospital Pedro Hispano

Senhora Da Hora, Matosinhos, Matosinhos, 4464-513, Portugal

Location

ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta

Almada, 2805-267, Portugal

Location

ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro

Aveiro, 3814-501, Portugal

Location

ULS De Braga, E.P.E. - Hospital de Braga

Braga, 4710-243, Portugal

Location

ULS Do Oeste E.P.E. - Unidade Caldas da Rainha

Caldas da Rainha, 2500-176, Portugal

Location

ULS Da Região De Leiria E.P.E.- Hospital de Santo André

Leiria, 2410-197, Portugal

Location

Unidade Local De Saúde De São José, E.P.E. - Hospital Curry Cabral

Lisbon, 1050-099, Portugal

Location

Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital Egas Moniz

Lisbon, 1349-019, Portugal

Location

ULS De Santo António, E.P.E. - Hospital de Santo António

Porto, 4099-001, Portugal

Location

ULS De São João, E.P.E. - Hospital de São João

Porto, 4200-319, Portugal

Location

ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia

Viana do Castelo, 4904-858, Portugal

Location

Caribbean Medical Research Center

San Juan, 00918, Puerto Rico

Location

Medical Practice SRL

Oradea, Bihor County, 410001, Romania

Location

Grandmed SRL

Oradea, Bihor County, 410159, Romania

Location

Spitalul Judetean de Urgenta Targoviste

Targoviste, Dâmbovița County, 130083, Romania

Location

CMI Dr Pop Lavinia

Baia Mare, Maramureş, 430222, Romania

Location

Novus Medical Clinica SRL

Ploieşti, Prahova, 100018, Romania

Location

Centrul Medical Sfantul Stefan

Timișoara, Timiș County, 300125, Romania

Location

Mariodiab Clinic SRL

Brasov, 500101, Romania

Location

Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed

Brasov, 500283, Romania

Location

Clinica Grivitei 224 S.R.L.

Brăila, 810197, Romania

Location

Diabs&Nutricare Srl

Bucharest, 040172, Romania

Location

Clinic of Diabetes Constanta

Constanța, 900591, Romania

Location

Clinical Emergency Sf. Apostol Andrei Hospital

Galati, 800578, Romania

Location

SC Consultmed SRL

Iași, 700547, Romania

Location

S.C. Dianutrilife Medica S.R.L.

Ploieşti, 100561, Romania

Location

Clinica Korall S.R.L. Satu Mare

Satu Mare, 440055, Romania

Location

Dentosim Queen Srl

Târgu Mureş, 540098, Romania

Location

Volosevich First City Clinical Hospital

Arkhangelsk, 163001, Russia

Location

SPb SBHI "Snegirev Maternity Hospital No. 6"

Saint Petersburg, 191014, Russia

Location

Medinet LLC

Saint Petersburg, 194356, Russia

Location

SPb SBHI City polyclinic #117

Saint Petersburg, 194358, Russia

Location

Medical Research Institute LLC

Saint Petersburg, 196084, Russia

Location

Solovyev Clinical Emergency Hospital

Yaroslavl, 150003, Russia

Location

Solovyov Clinical Emergency Hospital

Yaroslavl, 150003, Russia

Location

DIA - CLARUS s.r.o.

Bojnice, 97201, Slovakia

Location

MediTask, s.r.o

Bratislava, 83103, Slovakia

Location

MEDISPEKTRUM s.r.o.

Bratislava, 851 01, Slovakia

Location

DIA-MAX s.r.o.

Levice, 93401, Slovakia

Location

IN-DIA s.r.o.

Lučenec, 984 01, Slovakia

Location

DIA - SANTMART, s.r.o., Ambulancia diabetologie a poruch latkovej premeny a vyzivy

Martin, 036 01, Slovakia

Location

FUNKYSTUFF s.r.o

Nové Zámky, 940 59, Slovakia

Location

Diakom, spol. s r.o.

Poprad, 05801, Slovakia

Location

DIALIPID, s.r.o.

Prešov, 080 01, Slovakia

Location

Tatratrial s.r.o.

Rožňava, 04801, Slovakia

Location

Amb. Diabetologie a prouch latkovej premeny a vyzivy ENDIANT s.r.o.

Sereď, 926 01, Slovakia

Location

BENROD s.r.o.

Štúrovo, 943 01, Slovakia

Location

MUDr. Korecova, metabolicke centrum s.r.o.

Trenčín, 911 01, Slovakia

Location

Diabetes Care Centre & CDE Centre

Benoni, Gauteng, 1501, South Africa

Location

East Rand Physicians

Benoni, Gauteng, 1501, South Africa

Location

East Rand Physicians

Johannesburg, Gauteng, 1501, South Africa

Location

Centre for Diabetes

Johannesburg, Gauteng, 2198, South Africa

Location

Dr J Reddy

Durban, KwaZulu-Natal, 4450, South Africa

Location

Dr Pillay's Rooms

Durban, KwaZulu-Natal, 4450, South Africa

Location

Dr T Padayachee

eMkhomazi, KwaZulu-Natal, 4170, South Africa

Location

Centro Periférico de Especialidades Bola Azul

Almería, 04009, Spain

Location

ABS La Roca del Vallés_Endocrinología

La Roca Del Vallés, 08430, Spain

Location

ABS La Roca del Vallés

La Roca Del Vallés, 08430, Spain

Location

Hospital Infanta Leonor

Madrid, 28031, Spain

Location

Hospital Son Espases

Palma de Mallorca, 07120, Spain

Location

H. Infanta Luisa_Endocrino y Obesidad

Seville, 41010, Spain

Location

Kharkiv Regional Clinical Hospital - Endocrinology department

Kharkiv, 61058, Ukraine

Location

Khmelnytskyi Regional Hospital - Endocrinology department

Khmelnytskyi, 29000, Ukraine

Location

Ternopil Central District Hospital - Outpatient department

Ternopil, 46001, Ukraine

Location

Medical centre"Elitmedservis"LLC

Zaporizhzhia, 69037, Ukraine

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2Obesity

Interventions

semaglutide

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesOverweightOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Clinical Reporting Office (2834)
Organization
Novo Nordisk A/S

Study Officials

  • Clinical Transparency (dept. 2834)

    Novo Nordisk A/S

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 22, 2022

First Posted

August 24, 2022

Study Start

August 29, 2022

Primary Completion

March 5, 2025

Study Completion

April 9, 2025

Last Updated

May 11, 2026

Results First Posted

May 11, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

More information

Locations