The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females

NCT06377943 | Completed

• 1 other identifier: SIAT-IRB-240415-H0718
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This Study is focused on the interaction between resting metabolic rate (RMR), physical activity (PA), and thyroid hormones (TH). TH controls almost all the cell activities of the body so, it is known as one of the major regulatory hormones. This is the reason for individuals who suffer from thyroid disorders show abnormal metabolism. Recently it was suggested that interindividual variations in thyroid hormone levels also influence daily physical activity.

Conditions

Thyroid; Physical Activities; Resting Energy Expenditure

Outcome Measures

Primary Outcomes (10)

• Body weight

  Subjects will be asked to fast overnight and weight will be measured using a calibrated Seca body weight scale first thing in the morning on subjects wearing light clothes and no shoes.

  Measurements will take at the first day of the visit

• Height

  Measured by seca 217 stable stadiometer. Subjects wearing no shoes.

  Measurements will take at the first day of the visit

• Waist and Hip circumferences

  Waist and Hip circumferences will be measured using a whole body laser scanner.

  Measurements will take at the first day of the visit

• Fat mass

  Fat mass will be measured by Magnetic Resonance Imaging (Shanghai united imaging, uMR 790 ) or DXA (Hologic).

  Measurements will take at the first day of the visit

• Far free mass

  Fat free mass will be measured by Bioimpedance Analysis (Tanita, MC-980) or DXA (Hologic).

  Measurements will take at the first day of the visit

• Bone mass

  Bone mass will be measured by DXA (Hologic).

  Measurements will take at the first day of the visit

• Resting Metabolism

  Resting energy expenditure will be measured using indirect calorimetry via a respiratory hood system (Cosmed). The subject attends the lab after an overnight fast. The person lies down on a flatbed and the hood is placed over their head. Metabolic rates (oxygen consumption and CO2 production) are monitored for 30 minutes. Calorimeters will be assessed with a turbine test to ensure the accuracy of measurements. Validation via an alcohol burn will be performed monthly.

  Measurements will take at the first day of the visit.

• Physical activity

  Physical activity of the participants will be recorded using GT3X accelerometer worn near the hip for a consecutive period of 14 days. The monitor should not be worn while bathing or swimming. The first day is discarded along with any day where the wear time is less than 10 hours. For a valid measure, the goal is to get at least 2 weekday and 2 weekend days.

  Measurements last for 14 days

• Thyroid hormone

  Nurses will collect the blood samples on day 1. Levels of circulating thyroid hormones will be measured using radio immunoassay.

  Blood samples will collect at the first day of the visit.

• Resting Metabolism

  The whole room calorimeter/metabolic chamber (OMNICAL, Maastricht instrument) will be used to measure resting metabolic rate. The metabolic chamber is a sealed room with a continuous gas supply (CO2- 0.80×10-2, O2 -18.00×10-2), providing subjects with 24-hour energy expenditure data. The total energy expenditure of the subjects in MJ/day was plotted against time in 30-minute intervals over 24 hours. The lowest and most stable energy expenditure during sleep time was considered the RMR of the subjects, which occurred from 2:00 am to 5:00 am.

  measurements will take at the first day of visit

Secondary Outcomes (2)

• Total energy expenditure

  Measurements take for 14 days

• Total energy expenditure

  Measurements take at the first day of the visit

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study participants are adult healthy females.

You may qualify if:

• Female age ≥18;
• BMI≥18.5

You may not qualify if:

• Intended weight change exceeding 2kg within the past three months;
• Having any special medical diets or having eating disorders;
• Pregnant women or breastfeeding women;
• People who have metal implants in their bodies;
• Patients with metabolic diseases, infectious diseases, and genetic disorders such as hypothyroidism, and hyperthyroidism;
• Patients with a personal or family history of medullary thyroid carcinoma (MTC), or patients with rare type 2 multiple endocrine tumor syndrome (MEN2); People with a fear of needles (Trypanophobia), claustrophobia; People who are fear of blood (Hemophobia) or pathological hypotension;

Sponsors & Collaborators

• Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences: lead

Study Sites (1)

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

Shenzhen, Guangdong, 518000, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum samples and Urine samples

MeSH Terms

Conditions

Thyroid Diseases; Motor Activity

Condition Hierarchy (Ancestors)

Endocrine System Diseases; Behavior

Study Officials

• John R Speakman, PhD

  Shenzhen Institute of Advanced Technology, CAS

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, chief researcher

Study Record Dates

• First Submitted: April 17, 2024
• First Posted: April 22, 2024
• Study Start: June 29, 2024
• Primary Completion: October 31, 2024
• Study Completion: January 31, 2025
• Last Updated: August 15, 2025

Record last verified: 2025-08

Locations

CN (1)