Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
GLORIOSA
Randomized, Multicenter, Open-label, Phase 3 Study of Mirvetuximab Soravtansine in Combination With Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients With FRα-high Recurrent Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed After Second Line Platinum-based Chemotherapy Plus Bevacizumab
2 other identifiers
interventional
520
22 countries
264
Brief Summary
GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine + Bevacizumab as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3 ovarian-cancer
Started Mar 2023
Longer than P75 for phase_3 ovarian-cancer
264 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 30, 2022
CompletedFirst Posted
Study publicly available on registry
July 6, 2022
CompletedStudy Start
First participant enrolled
March 15, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 1, 2032
June 2, 2026
May 1, 2026
4 years
June 30, 2022
May 29, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Assess Progression-free survival (PFS)
Progression-free survival defined as assessed by BICR per RECIST v1.1, defined as the time from date of randomization until BICR-assessed PD or death due to any cause, whichever occurs first
Up to 4 years
Secondary Outcomes (8)
Assess Overall survival (OS)
Up to 10 years
Assess Safety and tolerability
Up to 10 years
Assess time to second disease progression (PFS2)
Up to 10 years
Assess Objective Response Rate (ORR)
Up to 10 years
Assess Duration of response (DOR)
Up to 10 years
- +3 more secondary outcomes
Study Arms (2)
Arm 1
EXPERIMENTALMirvetuximab Soravtansine (MIRV) plus Bevacizumab
Arm 2
ACTIVE COMPARATORBevacizumab monotherapy
Interventions
Participants will receive MIRV 6.0 mg/kg adjusted ideal body weight (AIBW) plus Bevacizumab 15mg/kg every 3 weeks
Eligibility Criteria
You may qualify if:
- Adult women \>/=18 years old
- Confirmed diagnosis of high-grade serous epithelial ovarian, primary peritoneal, or fallopian tube cancer
- Confirmed high FRα expression by regulatory-agency approved Ventana FOLR1 (FOLR1-2.1)
- Relapsed disease after frontline (first-line) platinum-based chemotherapy and must be plantinum-sensitive
- Willing and able to sign the informed consent form (ICF) and adhere to protocol requirements
- Negative pregnancy test and willing to use highly effective contraceptive method(s) while on study medication and for at least 7 months after the last dose of MIRV and 6 months after the last dose of bevacizumab
You may not qualify if:
- Endometrioid, clear cell, mucinous, or sarconmatous histology; mixed tumors containing any of the above or low grade/borderline ovarian tumor
- More than one line of prior chemotherapy before current/planned triplet therapy
- PD (progressive disease) while on or following platinum-based therapy
- Prior or whole-pelvis or wide-field radiotherapy
- \> Grade 1 peripheral neuropathy
- History of or concurrent ocular disorders
- Grade 4 thromboembolic events
- Not appropriate for bevacizumab treatment
- Requiring use of folate-containing supplements
- Prior hypersensitivity to monoclonal antibodies
- Pregnant or breatfeeding women
- Received prior MIRV or other FRα-targeting agents
- Untreated or symptomatic central nervous system metastases
- History of other malignancy within 3 years prior to signing study consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AbbVielead
- GOG Foundationcollaborator
Study Sites (264)
Usa Mitchell Cancer Institute /ID# 269661
Mobile, Alabama, 36604, United States
Honorhealth Virginia G. Piper Cancer Care Network - Biltmore /ID# 269987
Phoenix, Arizona, 85016, United States
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 269573
Irvine, California, 92618, United States
Moores Cancer Center at UC San Diego /ID# 269564
La Jolla, California, 92093, United States
Kaiser Permanente - Los Angeles Medical Center /ID# 269541
Los Angeles, California, 90027, United States
University Of California Irvine Medical Center /ID# 269572
Orange, California, 92868, United States
Stanford Women'S Cancer Center /ID# 269552
Palo Alto, California, 94304, United States
Kaiser Permanente - Riverside Medical Center /ID# 269539
Riverside, California, 92505, United States
Kaiser Permanente Zion Medical Center /ID# 269537
San Diego, California, 92120, United States
Kaiser Permanente - San Diego Medical Center /ID# 269540
San Diego, California, 92123, United States
Kaiser Permanente - San Marcos Medical Offices /ID# 269542
San Marcos, California, 92069, United States
Olive View-Ucla Medical Center /ID# 269584
Sylmar, California, 91342, United States
John Muir Health - Walnut Creek Medical Center /ID# 269575
Walnut Creek, California, 94598, United States
Broward General Medical Center /ID# 269577
Fort Lauderdale, Florida, 33316, United States
Regional Cancer Center /ID# 269558
Fort Myers, Florida, 33905, United States
Baptist Md Anderson Cancer Center - Jacksonville - Palm Avenue /ID# 269560
Jacksonville, Florida, 32207, United States
Mount Sinai Medical Center /ID# 269582
Miami, Florida, 33140, United States
Sarasota Memorial Hospital /ID# 269526
Sarasota, Florida, 34239, United States
Northside Hospital /ID# 269660
Atlanta, Georgia, 30342, United States
Rush University Medical Center /ID# 269583
Chicago, Illinois, 60612, United States
University of Chicago Medical Center /ID# 269546
Chicago, Illinois, 60637, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center /ID# 269110
Indianapolis, Indiana, 46202-5116, United States
St. Vincent Indianapolis Hospital /ID# 269107
Indianapolis, Indiana, 46260, United States
University of Iowa /ID# 269566
Iowa City, Iowa, 52242, United States
The University of Kansas Cancer Center - Westwood /ID# 269106
Westwood, Kansas, 66205, United States
Baptist Health Lexington /ID# 269568
Lexington, Kentucky, 40503, United States
University of Kentucky Chandler Medical Center. /ID# 269536
Lexington, Kentucky, 40536, United States
Louisiana State University Health Sciences Center - New Orleans /ID# 269559
New Orleans, Louisiana, 70112, United States
Ochsner Medical Center - Jefferson Highway /ID# 269530
New Orleans, Louisiana, 70121, United States
Maine Medical Center - Scarborough Campus /ID# 269555
Scarborough, Maine, 04074, United States
Johns Hopkins Hospital /ID# 269579
Baltimore, Maryland, 21287, United States
Sinai Hospital Of Baltimore /ID# 269567
Manchester, Maryland, 21215, United States
GBMC Cancer Center /ID# 269561
Towson, Maryland, 21204-6831, United States
Tufts Medical Center /ID# 269547
Boston, Massachusetts, 02111-1552, United States
Baystate Medical Center /ID# 269544
Springfield, Massachusetts, 01199, United States
Corewell Health /ID# 269562
Grand Rapids, Michigan, 49503, United States
Minnesota Oncology - Coon Rapids Clinic /ID# 269550
Coon Rapids, Minnesota, 55433, United States
Nebraska Methodist Hospital /ID# 269580
Omaha, Nebraska, 68114, United States
The Center Of Hope /ID# 269528
Reno, Nevada, 89511, United States
Dartmouth-Hitchcock Medical Center /ID# 269576
Lebanon, New Hampshire, 03756, United States
John Theurer Cancer Center /ID# 269109
Hackensack, New Jersey, 07601, United States
The Valley Hospital /ID# 269548
Paramus, New Jersey, 07652, United States
Holy Name Medical Center /ID# 269543
Teaneck, New Jersey, 07666, United States
New York Oncology Hematology - Albany Cancer Center /ID# 269565
Albany, New York, 12206-5013, United States
Women'S Cancer Care Associates /ID# 269553
Albany, New York, 12208, United States
Northwell Health Center for Advanced Medicine. /ID# 269108
Lake Success, New York, 11042, United States
Perlmutter Cancer Center at NYU Langone Hematology Oncology Associates - Mineola /ID# 269534
Mineola, New York, 11501, United States
NYU Laura and Isaac Perlmutter Cancer Center /ID# 269556
New York, New York, 10016, United States
Icahn School of Medicine at Mount Sinai /ID# 269529
New York, New York, 10029, United States
University of North Carolina at Chapel Hill /ID# 269563
Chapel Hill, North Carolina, 27514, United States
Duke Cancer Institute /ID# 269557
Durham, North Carolina, 27710, United States
University of Cincinnati /ID# 269578
Cincinnati, Ohio, 45267-2827, United States
Jamescare Gynecologic Oncology At Mill Run /ID# 269105
Hilliard, Ohio, 43026, United States
Kettering Medical Center /ID# 269585
Kettering, Ohio, 45429, United States
OU Health - Stephenson Cancer Center /ID# 269525
Oklahoma City, Oklahoma, 73104, United States
Oklahoma Cancer Specialists and Research Institute /ID# 269527
Tulsa, Oklahoma, 74146, United States
Willamette Valley Cancer Institute and Research Center /ID# 269988
Eugene, Oregon, 97401, United States
Compass Oncology - Rose Quarter /ID# 270131
Portland, Oregon, 97227, United States
Oregon Health and Science University /ID# 269581
Portland, Oregon, 97239, United States
University Of Pittsburgh Medical Center Magee - Womens Hospital /ID# 269659
Pittsburgh, Pennsylvania, 15213, United States
Allegheny Health Network West Penn Hospital /ID# 269551
Pittsburgh, Pennsylvania, 15244, United States
Asplundh Cancer Pavilion /ID# 269574
Willow Grove, Pennsylvania, 19090, United States
Sanford Cancer Center /ID# 269535
Sioux Falls, South Dakota, 57104, United States
West Cancer Center and Research Institute - Germantown /ID# 269569
Germantown, Tennessee, 38138, United States
Texas Oncology - Austin Central /ID# 269531
Austin, Texas, 78731, United States
Texas Oncology - Bedford /ID# 269571
Bedford, Texas, 76022, United States
Texas Oncology - Methodist Dallas Cancer Center /ID# 269554
Dallas, Texas, 75203, United States
Texas Oncology - Fort Worth Cancer Center /ID# 269532
Fort Worth, Texas, 76104, United States
US Oncology Research Investigational Products Center /ID# 278746
Irving, Texas, 75063, United States
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 269549
San Antonio, Texas, 78240, United States
University of Virginia Health System /ID# 269545
Charlottesville, Virginia, 22908-0816, United States
Virginia Oncology Associates - Norfolk (Lake Wright) /ID# 269533
Norfolk, Virginia, 23502, United States
VCU Health Adult Outpatient Pavillion /ID# 269570
Richmond, Virginia, 23219, United States
Swedish Cancer Institute /ID# 269538
Seattle, Washington, 98104-3588, United States
Sanatorio De La Mujer /ID# 269352
Rosario, Santa Fe Province, 2000, Argentina
Hospital Italiano de Buenos Aires /ID# 269356
Buenos Aires, 1181, Argentina
Hospital Italiano de Córdoba (Sociedad de Beneficencia Hospital Italiano) /ID# 269090
Córdoba, 5004, Argentina
Isis Centro Especializado De Luce /ID# 269353
Santa Fe, 3000, Argentina
Westmead Hospital /ID# 269362
Westmead, New South Wales, 2145, Australia
Gold Coast University Hospital /ID# 269365
Southport, Queensland, 4215, Australia
Ballarat Base Hospital /ID# 269364
Ballarat, Victoria, 3350, Australia
Monash Health - Monash Medical Centre /ID# 269360
Clayton, Victoria, 3168, Australia
Cabrini Hospital Malvern /ID# 269359
Malvern, Victoria, 3144, Australia
Peter MacCallum Cancer Centre /ID# 269361
Melbourne, Victoria, 3000, Australia
Epworth Hospital /ID# 269363
Richmond, Victoria, 3121, Australia
St. John Of God Subiaco Hospital /ID# 269358
Subiaco, Western Australia, 6008, Australia
Imelda Ziekenhuis /ID# 269369
Bonheiden, Antwerpen, 2820, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 269368
Brussels, Brussels Capital, 1200, Belgium
Grand Hôpital De Charleroi - Notre Dame /ID# 269367
Charleroi, Hainaut, 6000, Belgium
AZ Sint-Lucas /ID# 269366
Ghent, Oost-Vlaanderen, 9000, Belgium
Universitair Ziekenhuis Leuven /ID# 269370
Leuven, Vlaams-Brabant, 3000, Belgium
AZ-Delta. /ID# 269091
Roeselare, West-Vlaanderen, 8800, Belgium
UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 269371
Namur, 5000, Belgium
Hospital Santa Izabel /ID# 269384
Salvador, Estado de Bahia, 40050-410, Brazil
Catarina Pesquisa Clinica /ID# 269379
Itajaí, Santa Catarina, 88301-220, Brazil
Beneficência Portuguesa de São Paulo /ID# 269092
São Paulo, São Paulo, 01323-001, Brazil
Hospital Nove De Julho /ID# 269375
São Paulo, São Paulo, 01409-002, Brazil
Complex Oncology Center - Shumen /ID# 269372
Shumen, 9705, Bulgaria
Comprehensive Cancer Center /ID# 269373
Vratsa, 3000, Bulgaria
Arthur J.E Child Comprehensive Cancer Centre /ID# 269388
Calgary, Alberta, T2N 5G2, Canada
Cross Cancer Institute /ID# 269392
Edmonton, Alberta, T6G 1Z2, Canada
Bc Cancer Agency - Fraser Valley Centre /ID# 269398
Surrey, British Columbia, V3V 1Z2, Canada
BC Cancer - Vancouver /ID# 269394
Vancouver, British Columbia, V5Z 4E6, Canada
Juravinski Cancer Centre - Hamilton Health Sciences /ID# 269396
Hamilton, Ontario, L8V 5C2, Canada
Kingston General Hospital /ID# 269397
Kingston, Ontario, K7L 2V7, Canada
The Ottawa Hospital - General Campus /ID# 269391
Ottawa, Ontario, K1H 8L6, Canada
Princess Margaret Cancer Centre /ID# 269390
Toronto, Ontario, M5G 2M9, Canada
Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 269395
Montreal, Quebec, H1T 2M4, Canada
CHUM - Centre hospitalier de l'Universite de Montréal /ID# 269387
Montreal, Quebec, H2X 0A9, Canada
McGill University Health Centre - Glen Site. /ID# 269389
Montreal, Quebec, H4A 3J1, Canada
CIUSSS Estrie - Sherbrooke University Hospital Center /ID# 269393
Sherbrooke, Quebec, J1H 5N4, Canada
The first affiliated hospital of bengbu medical college
Bengbu, Anhui, 233000, China
Capital Medical University (Cmu)
Beijing, Beijing Municipality, 100069, China
Beijing Cancer Hospital
Beijing, Beijing Municipality, 100142, China
Fujian Province Cancer Hospital
Fuzhou, Fujian, 350014, China
The First Affiliated Hospital, Sun-Yat Sen University
Guangzhou, Guangdong, 510080, China
Sun Yat-Sen University (Sysu) - Sun Yat-Sen Memorial Hospital
Guangzhou, Guangdong, 510120, China
Affiliated Cancer Hospital of Guangxi Medical University
Nanning, Guangxi, 530021, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450014, China
Hubei Cancer Hospital
Wuhan, Hubei, 430079, China
Hunan Province Cancer Hospital
Changsha, Hunan, 410013, China
The First Bethune Hospital Of Jilin University
Changchun, Jilin, 130499, China
Liaoning Cancer Hospital & Institute
Shenyang, Liaoning, 110042, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, 710061, China
Qilu Hospital Of Shandong University
Jinan, Shandong, 250014, China
Shandong Cancer Hospital
Jinan, Shandong, 250117, China
LinYi Cancer Hospital
Linyi, Shandong, 276001, China
Fudan University Cancer Hospital /ID# 271025
Shanghai, Shanghai Municipality, 200032, China
Shanxi Cancer Hospital
Taiyuan, Shanxi, 030000, China
West China Second University Hospital, Sichuan University
Chengdu, Sichuan, 610000, China
Tianjin Cancer Hospital
Tianjin, Tianjin Municipality, 300060, China
Cancer Hospital Affliated to Xinjiang Medical University
Ürümqi, Xinjiang, 830011, China
Yunnan Province Cancer Hospital
Kunming, Yunnan, 650106, China
The Affiliated Women'S Hospital Of Zhejiang University
Hangzhou, Zhejiang, 310006, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China
Fakultní Nemocnice Brno - Obilní Trh /ID# 269401
Brno, Brno-mesto, 602 00, Czechia
General University Hospital in Prague, Charles University /ID# 269402
Prague, Ceske Budejovice, 120 00, Czechia
Nemocnice Novy Jicin /ID# 269400
Nový Jičín, Novy Jicin, 741 01, Czechia
Fakultni nemocnice Ostrava /ID# 269403
Ostrava, Ostrava-mesto, 708 52, Czechia
Hopitaux Universitaires de Strasbourg - Le Nouvel Hopital Civil (NHC) /ID# 269419
Strasbourg, Bas-Rhin, 67000, France
Hôpital La Timone /ID# 269421
Marseille, Bouches-du-Rhone, 13885, France
Chu Dijon /Id# 269417
Dijon, Bourgogne-Franche-Comté, 21000, France
CHU Brest /ID# 269422
Brest, Finistere, 29200, France
Centre Leon Berard /ID# 269418
Lyon, Rhone, 69373, France
Institut Curie /ID# 269420
Paris, Île-de-France Region, 75248, France
Klinikum Esslingen /ID# 269435
Esslingen am Neckar, Baden-Wurttemberg, 73730, Germany
Universitaetsklinikum Heidelberg /ID# 269438
Heidelberg, Baden-Wurttemberg, 69120, Germany
Universitaetsklinikum Erlangen /ID# 269439
Erlangen, Bavaria, 91054, Germany
Universitaetsklinikum Giessen /ID# 269432
Giessen, Hesse, 35392, Germany
Onkologische Schwerpunktpraxis Bielefeld /ID# 269440
Bielefeld, North Rhine-Westphalia, 33604, Germany
Universitaetsklinikum Bonn /ID# 269434
Bonn, North Rhine-Westphalia, 53127, Germany
Klinikum Dortmund Klinikzentrum Mitte /ID# 269441
Dortmund, North Rhine-Westphalia, 44137, Germany
Universitaetsmedizin Mainz /ID# 269442
Mainz, Rhineland-Palatinate, 55131, Germany
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 269433
Dresden, Saxony, 01307, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 269429
Hamburg, 20246, Germany
Krankenhaus Jerusalem /ID# 269430
Hamburg, 20357, Germany
General Hospital of Athens Alexandra /ID# 269444
Athens, Attica, 11528, Greece
St. Luke's Hospital S.A. /ID# 269445
Panórama, Thessaloniki, 55236, Greece
Hygeia Hospital /ID# 270132
Athens, 15123, Greece
IASO Hospital /ID# 269443
Marousi, 15123, Greece
St James Hospital /ID# 269446
Dublin, Dublin, D08 NHY1, Ireland
Bon Secours Cork Hospital /ID# 269449
Cork, T12 DV56, Ireland
Cork University Hospital /ID# 269451
Cork, T12 E8YV, Ireland
Beaumont Hospital /ID# 269452
Dublin, D09 XR63, Ireland
University Hospital Galway /ID# 269447
Galway, H91 YR71, Ireland
Sligo General Hospital /ID# 269448
Sligo, F91 H684, Ireland
Waterford Regional Hospital /ID# 269450
Waterford, X91 ER8E, Ireland
Edith Wolfson Medical Center /ID# 269461
Holon, Central District, 5822012, Israel
Meir Medical Center /ID# 269454
Kfar Saba, Central District, 4428164, Israel
Rabin Medical Center /ID# 269456
Petah Tikva, Central District, 4941492, Israel
Kaplan Medical Center /ID# 269457
Rehovot, Central District, 7660101, Israel
The Chaim Sheba Medical Center /ID# 269094
Ramat Gan, Tel Aviv, 5265601, Israel
Tel Aviv Sourasky Medical Center /ID# 269455
Tel Aviv, Tel Aviv, 6423906, Israel
The Lady Davis Carmel Medical Center /ID# 269453
Haifa, 34362, Israel
Shaare Zedek Medical Center /ID# 269459
Jerusalem, 9103102, Israel
Hadassah Medical Center-Hebrew University /ID# 269458
Jerusalem, 91120, Israel
ZIV Medical Center /ID# 269460
Safed, 1311001, Israel
Azienda Ospedaliero Universitaria Careggi /ID# 269465
Florence, Firenze, 50134, Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 269474
Meldola, Forlì-Cesena, 47014, Italy
Ente Ospedaliero Ospedali Galliera /ID# 269472
Genoa, Genova, 16128, Italy
Ospedale San Martino /ID# 269469
Genoa, Genova, 16132, Italy
IRCCS Istituto Clinico Humanitas /ID# 269473
Rozzano, Lombardy, 20089, Italy
IRCCS Ospedale San Raffaele /ID# 269475
Milan, Milano, 20132, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori /ID# 269477
Milan, Milano, 20133, Italy
Casa di Cura San Pio X /ID# 277973
Milan, Milano, 20159, Italy
Istituto Nazionale Tumori Irccs Fondazione G. Pascale /ID# 269097
Naples, Napoli, 80131, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 269470
Rome, Roma, 00161, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 269096
Rome, Roma, 00168, Italy
Ospedale di Mirano - Azienda ULSS 3 /ID# 269462
Mirano, Venezia, 30035, Italy
IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 269476
Bologna, 40138, Italy
Ospedale Cannizzaro /ID# 269478
Catania, 95126, Italy
Alessandro Manzoni Hospital /ID# 269467
Lecco, 23900, Italy
Azienda USL Toscana Nord Ovest - Ospedale San Luca /ID# 269095
Lucca, 55100, Italy
Azienda Ospedaliero Universitaria Di Parma /ID# 269466
Parma, 43100, Italy
Fondazione IRCCS Policlinico San Matteo /ID# 269463
Pavia, 27100, Italy
AUSL Piacenza-Ospedale Guglielmo da Saliceto /ID# 269468
Piacenza, 29121, Italy
New Hospital of Prato - S. Stefano /ID# 269464
Prato, 59100, Italy
AUSL di Reggio Emilia - Arcispedale Santa Maria Nuova /ID# 269471
Reggio Emilia, 42122, Italy
Aichi Cancer Center /ID# 274332
Nagoya, Aichi-ken, 464-8681, Japan
Chiba University Hospital /ID# 274371
Chiba, Chiba, 260-8677, Japan
The Jikei University Kashiwa Hospital /ID# 274334
Kashiwa, Chiba, 277-0004, Japan
National Hospital Organization Shikoku Cancer Center /ID# 276078
Matsuyama, Ehime, 791-0280, Japan
Kurume University Hospital /ID# 274337
Kurume-shi, Fukuoka, 830-0011, Japan
Sapporo Medical University Hospital /ID# 274330
Sapporo, Hokkaido, 060-8543, Japan
Hokkaido University Hospital /ID# 274331
Sapporo, Hokkaido, 060-8648, Japan
Hyogo Cancer Center /ID# 274323
Akashi-shi, Hyōgo, 673-8558, Japan
Iwate Medical University Hospital - Yahabacho /ID# 274635
Yahaba, Iwate, 028-3695, Japan
Kagoshima University Hospital /ID# 276081
Kagoshima, Kagoshima-ken, 890-8520, Japan
Tokai University Hospital /ID# 274336
Isehara, Kanagawa, 259-1193, Japan
Tohoku University Hospital /ID# 274327
Sendai, Miyagi, 980-8574, Japan
Niigata University Medical & Dental Hospital /ID# 274329
Niigata, Niigata, 951-8520, Japan
Okayama University Hospital /ID# 274324
Okayama, Okayama-ken, 700-8558, Japan
Kindai University Hospital /ID# 274335
Sakai-shi, Osaka, 590-0197, Japan
Osaka Medical And Pharmaceutical University Hospital /ID# 276079
Takatsuki, Osaka, 569-8686, Japan
Saitama Medical University International Medical Center /ID# 274953
Hidaka, Saitama, 350-1298, Japan
Shizuoka Cancer Center /ID# 274325
Sunto-gun, Shizuoka, 411-8777, Japan
Jichi Medical University Hospital /ID# 274634
Shimotsuke-shi, Tochigi, 329-0498, Japan
National Cancer Center Hospital /ID# 274321
Chuo-Ku, Tokyo, 104-0045, Japan
The Cancer Institute Hospital Of JFCR /ID# 274326
Koto-ku, Tokyo, 135-8550, Japan
Keio University Hospital /ID# 276159
Shinjuku-ku, Tokyo, 160-8582, Japan
The Jikei University Hospital /ID# 276160
Tokyo, 105-8461, Japan
The Medical City /ID# 269493
Pasig, National Capital Region, 1600, Philippines
East Avenue Medical Center /ID# 269099
Quezon City, National Capital Region, 1104, Philippines
Cardinal Santos Medical Center /ID# 269100
San Juan City, National Capital Region, 1502, Philippines
Wielkopolskie Centrum Onkologii /ID# 269494
Poznan, Greater Poland Voivodeship, 61-866, Poland
Jagiellonskie Centrum Innowacji Sp. z o.o. /ID# 269497
Krakow, Lesser Poland Voivodeship, 30-348, Poland
Mazowiecki Szpital Wojewodzki im. Sw. Jana Pawla II w Siedlcach Sp. z o.o. /ID# 269500
Siedlce, Masovian Voivodeship, 08-110, Poland
Szpitale Pomorskie Sp. z o.o. /ID# 269495
Gdynia, Pomeranian Voivodeship, 81-519, Poland
National Cancer Center /ID# 269481
Goyang-si, Gyeonggido, 10408, South Korea
CHA Bundang Medical Center /ID# 269489
Seongnam, Gyeonggido, 13496, South Korea
Seoul National University Bundang Hospital /ID# 269482
Seongnam-si, Gyeonggido, 13620, South Korea
Keimyung University Dongsan Hospital /ID# 269488
Daegu, Gyeongsangbuk-do, 42601, South Korea
Korea University Anam Hospital /ID# 269486
Seoul, Seoul Teugbyeolsi, 02841, South Korea
Seoul National University Hospital /ID# 269479
Seoul, Seoul Teugbyeolsi, 03080, South Korea
Yonsei University Health System Severance Hospital /ID# 269483
Seoul, Seoul Teugbyeolsi, 03722, South Korea
Asan Medical Center /ID# 269480
Seoul, Seoul Teugbyeolsi, 05505, South Korea
Gangnam Severance Hospital /ID# 269484
Seoul, Seoul Teugbyeolsi, 06273, South Korea
Samsung Medical Center /ID# 269487
Seoul, Seoul Teugbyeolsi, 06351, South Korea
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 269485
Seoul, Seoul Teugbyeolsi, 06591, South Korea
Korea University Guro Hospital /ID# 269490
Seoul, Seoul Teugbyeolsi, 08308, South Korea
Complejo Hospitalario Universitario A Coruña /ID# 269414
A Coruña, A Coruna, 15006, Spain
Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 269409
L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitario Reina Sofia /ID# 270296
Córdoba, Cordoba, 14004, Spain
Hospital Universitario Virgen de la Victoria /ID# 269413
Málaga, Malaga, 29010, Spain
Clinica Universidad de Navarra - Pamplona /ID# 269410
Pamplona, Navarre, 31008, Spain
Hospital Universitari Vall d'Hebron /ID# 269406
Barcelona, 08035, Spain
Hospital Clinic de Barcelona /ID# 269408
Barcelona, 08036, Spain
Hospital Universitari De Girona Doctor Josep Trueta /ID# 269411
Girona, 17007, Spain
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 269405
Madrid, 28027, Spain
Hospital Universitario La Paz /ID# 269407
Madrid, 28046, Spain
Hospital Clínico Universitario de Valencia /ID# 269412
Valencia, 46010, Spain
Baskent Universitesi Adana Uyg. Ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 270174
Adana, 01120, Turkey (Türkiye)
Hacettepe University Faculty of Medicine /ID# 269521
Ankara, 06230, Turkey (Türkiye)
Baskent Universitesi Ankara Hastanesi /ID# 269524
Ankara, 06490, Turkey (Türkiye)
Cheltenham General Hospital /ID# 269427
Cheltenham, Gloucestershire, GL53 7AN, United Kingdom
Guy's Hospital /ID# 269426
London, Greater London, SE1 9RT, United Kingdom
The Royal Marsden - Chelsea /ID# 269102
London, Greater London, SW3 6JJ, United Kingdom
Mount Vernon Hospital /ID# 269423
Northwood, Greater London, HA6 2RN, United Kingdom
University Hospital Southampton /ID# 269425
Southampton, Hampshire, SO16 6YD, United Kingdom
The Royal Marsden - Sutton /ID# 269103
Sutton, Surrey, SM2 5PT, United Kingdom
The Christie /ID# 269428
Manchester, M20 4BX, United Kingdom
Singleton Hospital /ID# 269424
Swansea, SA2 8QA, United Kingdom
Related Publications (1)
O'Malley DM, Myers T, Wimberger P, Van Gorp T, Redondo A, Cibula D, Nicum S, Rodrigues M, Backes FJ, Barlin JN, Lewin SN, Lim P, Pothuri B, Diver E, Banerjee S, Lorusso D. Maintenance with mirvetuximab soravtansine plus bevacizumab vs bevacizumab in FRalpha-high platinum-sensitive ovarian cancer. Future Oncol. 2024;20(32):2423-2436. doi: 10.1080/14796694.2024.2372241. Epub 2024 Jul 31.
PMID: 39082675DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
ABBVIE INC.
AbbVie
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 30, 2022
First Posted
July 6, 2022
Study Start
March 15, 2023
Primary Completion (Estimated)
April 1, 2027
Study Completion (Estimated)
May 1, 2032
Last Updated
June 2, 2026
Record last verified: 2026-05
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- For details on when studies are available for sharing, visit https://vivli.org/ourmember/abbvie/
- Access Criteria
- To learn more about the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/
AbbVie is committed to responsible clinical trial data sharing. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information.