NCT03645772

Brief Summary

Rapid force production declines as a consequence of ageing. Given the functional relevance of rapid force production, exercise interventions in older adults should aim at improving the capacity to produce force rapidly. To improve this capacity, exercises should be performed with the intention to develop high speeds, as supported by previous work. Human locomotion fundamentally consists of multi-joint movements and rapidly coupled eccentric-concentric muscle actions, known as stretch-shortening cycle (SSC) activities or plyometrics. Plyometrics might therefore be used to optimize power production. However, there is limited research on the feasibility of plyometrics in older adults and its potential effects on rapid force production and functional capacity. This study will test the feasibility of a 12-week plyometric exercise intervention in older men and compare its effects on rapid force production to a traditional resistance exercise or walking intervention.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
42

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2018

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 29, 2018

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 19, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 19, 2018

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

August 17, 2018

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 24, 2018

Completed
Last Updated

August 24, 2018

Status Verified

August 1, 2018

Enrollment Period

5 months

First QC Date

August 17, 2018

Last Update Submit

August 23, 2018

Conditions

Outcome Measures

Primary Outcomes (4)

  • Rapid force production

    Subjects perform a test protocol on a sledge apparatus, consisting of explosive isometric voluntary contractions for the leg-extensor muscles of the right leg. The inclination of the sledge is 20° to horizontal. The seat of the sledge is inclined backwards (130°). The knee joint angle is set at 90° and the hip angle at 70°. The point of force application is aligned with the head of the fifth metatarsal. Subjects are instructed to kick as fast and as hard as possible and maintain their maximum force for approximately 3s. The rate of force development (N/s) is defined as the linear slope of the force-time curve and is measured from the onset of movement till 100 ms.

    Change from baseline in rapid force production at 12 weeks

  • Jumping height in squat jump

    Subjects perform a test protocol on a sledge apparatus, consisting of squat jumps (SJ), countermovement jumps (CMJ), and drop jumps (DJ). The inclination of the sledge is 20° to horizontal. The seat of the sledge is inclined backwards (130°). A force platform is built in perpendicular to the jumping direction. A speed sensor is attached to the seat of the sledge, which is used to assess the transition point between braking and push-off phases and to calculate jumping height (in cm).

    Change from baseline in jumping height at 12 weeks

  • Jumping height in countermovement jump

    Subjects perform a test protocol on a sledge apparatus, consisting of squat jumps (SJ), countermovement jumps (CMJ), and drop jumps (DJ). The inclination of the sledge is 20° to horizontal. The seat of the sledge is inclined backwards (130°). A force platform is built in perpendicular to the jumping direction. A speed sensor is attached to the seat of the sledge, which is used to assess the transition point between braking and push-off phases and to calculate jumping height (in cm).

    Change from baseline in jumping height at 12 weeks

  • Jumping height in drop jump

    Subjects perform a test protocol on a sledge apparatus, consisting of squat jumps (SJ), countermovement jumps (CMJ), and drop jumps (DJ). The inclination of the sledge is 20° to horizontal. The seat of the sledge is inclined backwards (130°). A force platform is built in perpendicular to the jumping direction. A speed sensor is attached to the seat of the sledge, which is used to assess the transition point between braking and push-off phases and to calculate jumping height (in cm).

    Change from baseline in jumping height at 12 weeks

Secondary Outcomes (8)

  • Leg press one-repetition maximum

    Change from baseline in leg press 1-RM at 12 weeks

  • Maximal isometric strength

    Change from baseline in maximal isometric strength at 12 weeks

  • Maximal isokinetic strength

    Change from baseline in maximal isokinetic strength at 12 weeks

  • Stair Climbing performance

    Change from baseline in Stair Climbing performance at 12 weeks

  • Gait speed

    Change from baseline in gait speed at 12 weeks

  • +3 more secondary outcomes

Study Arms (3)

Plyometric exercise

EXPERIMENTAL

12-week progressive exercise program, consisting of plyometric exercises such as countermovement jump, forward and sideways step-up.

Other: Exercise intervention

Resistance exercise

ACTIVE COMPARATOR

12-week resistance exercise program for the leg muscles (2-4 sets of 8-15 repetitions at 8-15RM, leg press, leg extension, calve extension).

Other: Exercise intervention

Walking

ACTIVE COMPARATOR

12-week progressive walking program.

Other: Exercise intervention

Interventions

12-week progressive training intervention

Plyometric exerciseResistance exerciseWalking

Eligibility Criteria

Age65 Years - 80 Years
Sexmale
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may not qualify if:

  • No systematic engagement in (resistance) exercise in the 12-months prior to participation
  • Cardiovascular disease
  • Neurological disorders
  • Cognitive malfunctioning
  • Severe knee or hip problems

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Movement Sciences

Leuven, 3001, Belgium

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

August 17, 2018

First Posted

August 24, 2018

Study Start

January 29, 2018

Primary Completion

June 19, 2018

Study Completion

June 19, 2018

Last Updated

August 24, 2018

Record last verified: 2018-08

Data Sharing

IPD Sharing
Will not share

Locations