Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics

NCT05414019 | Enrolling By Invitation DMC

• 1 other identifier: 799/2234
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluation of root resorption following different mandibular incisors intrusive mechanics : A randomized clinical trial

Conditions

Orthodontic Tooth Movement; Intrusion of Tooth; Resorption, Root

Keywords

Intrusion; Root resorption; Cone beam computed tomography; Utility Arch; Nitinol reverse curve wire; Miniscrew; Mandibular incisors

Outcome Measures

Primary Outcomes (2)

• Linear amount of root resorption

  Cone beam computed tomography linear measurements

  Change in Linear Root resorption at 6 months

• Volumetric amount of root resorption

  Cone beam computed tomography volumetric measurements

  Change in Volumetric Root resorption at 6 months

Study Arms (3)

Mini-screw

ACTIVE COMPARATOR

7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine.

Other: Mini-screw

Utility arch

ACTIVE COMPARATOR

7 patients will receive an intrusive force delivered by intrusive utility arch.

Other: Utility arch

Nitinol reverse curve wire

ACTIVE COMPARATOR

7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.

Other: Nitinol reverse curve wire

Interventions

Mini-screw OTHER

7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine.

Mini-screw

Utility arch OTHER

7 patients will receive an intrusive force delivered by intrusive utility arch.

Utility arch

Nitinol reverse curve wire OTHER

7 patients will receive an intrusive force delivered by Nitinol reverse curve wire

Nitinol reverse curve wire

Eligibility Criteria

• Age: 12 Years - 16 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Patient will be included in this study if has:
• An age range between 12 and 16 years.
• Deep overbite with excessive curve of Spee of more than 5mm
• Over erupted lower incisors.
• Permanent teeth are all present (except for third molar).
• No previous orthodontic treatment.
• No indications or symptoms of periodontal disease in the past or present, as determined by clinical and radiographic examination

You may not qualify if:

• Patients who needed surgery to fix skeletal problems.
• Any previous trauma or root canal therapy
• Missing lower incisor.
• Patients with congenital dentoskeletal disorders

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Al Azhar University

Cairo, Egypt

Location

Related Publications (9)

• Goel P, Tandon R, Agrawal KK. A comparative study of different intrusion methods and their effect on maxillary incisors. J Oral Biol Craniofac Res. 2014 Sep-Dec;4(3):186-91. doi: 10.1016/j.jobcr.2014.11.007. Epub 2014 Dec 6.

  PMID: 25737942 BACKGROUND

• Hamdan AM, Lewis SM, Kelleher KE, Elhady SN, Lindauer SJ. Does overbite reduction affect smile esthetics? Angle Orthod. 2019 Nov;89(6):847-854. doi: 10.2319/030819-177.1. Epub 2019 Jul 15.

  PMID: 31306077 BACKGROUND

• Piancino MG, Tortarolo A, Di Benedetto L, Crincoli V, Falla D. Chewing Patterns and Muscular Activation in Deep Bite Malocclusion. J Clin Med. 2022 Mar 19;11(6):1702. doi: 10.3390/jcm11061702.

  PMID: 35330027 BACKGROUND

• Nielsen IL. Vertical malocclusions: etiology, development, diagnosis and some aspects of treatment. Angle Orthod. 1991 Winter;61(4):247-60. doi: 10.1043/0003-3219(1991)0612.0.CO;2.

  PMID: 1763835 BACKGROUND

• Sonnesen L, Svensson P. Temporomandibular disorders and psychological status in adult patients with a deep bite. Eur J Orthod. 2008 Dec;30(6):621-9. doi: 10.1093/ejo/cjn044. Epub 2008 Aug 5.

  PMID: 18684706 BACKGROUND

• Guven BA, Ciger S. Evaluation of the Effect of Fixed Anterior Biteplane Treatment on Temporomandibular Joint in Patients with Deep Bite. Turk J Orthod. 2020 Mar 1;33(1):8-12. doi: 10.5152/TurkJOrthod.2020.19108. eCollection 2020 Mar.

  PMID: 32284893 BACKGROUND

• Millett DT, Cunningham SJ, O'Brien KD, Benson PE, de Oliveira CM. Orthodontic treatment for deep bite and retroclined upper front teeth in children. Cochrane Database Syst Rev. 2018 Feb 1;2(2):CD005972. doi: 10.1002/14651858.CD005972.pub4.

  PMID: 29390172 BACKGROUND

• Nanda R. The differential diagnosis and treatment of excessive overbite. Dent Clin North Am. 1981 Jan;25(1):69-84. No abstract available.

  PMID: 6937401 BACKGROUND

• Burstone CR. Deep overbite correction by intrusion. Am J Orthod. 1977 Jul;72(1):1-22. doi: 10.1016/0002-9416(77)90121-x.

  PMID: 267433 BACKGROUND

MeSH Terms

Conditions

Root Resorption

Condition Hierarchy (Ancestors)

Tooth Resorption; Tooth Diseases; Stomatognathic Diseases

Study Officials

• Mahmoud S Nassar, student

  Al-Azhar University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Observation: Each patient will be followed up on periodic base for progress evaluation and integrity checks, as well as root resorption will be evaluated using CBCT images taken before and after the intrusion. Ethical considerations: An informed consent form (attached copy) that explains every step in the research will be given and discussed carefully with the patient and his/her parents before participation in the study and should be signed freely. The objectives of the study will be discussed and explained with the patients and / or their guardians and they will receive a copy of the consent form as well. Data management and analysis: The data will be collected, tabulated, and statistically analyzed using Statistical Package for Social Sciences (SPSS program, version 18, Inc., Chicago, III).
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Model Details: The total sample of patients will be randomly divided into three equal groups: Miniscrew: 7 patients will receive an intrusive force delivered by elastics from 2 miniscrews between mandibular lateral incisor and mandibular canine. Utility arch: 7 patients will receive an intrusive force delivered by intrusive utility arch. Nitinol reverse curve wire: 7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.

Study Record Dates

• First Submitted: May 29, 2022
• First Posted: June 10, 2022
• Study Start: May 15, 2025
• Primary Completion: January 1, 2026
• Study Completion: January 1, 2026
• Last Updated: April 25, 2025

Record last verified: 2025-04

Locations

EG (1)