Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Root Resorption

NCT06198322 | Unknown

• 1 other identifier: REC-FDBSU/P206042023-03/AR
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate and compare the effect of PRF and vitamin Dꝫ injections on root resorption by using CBCT

Conditions

Root Resorption

Keywords

platelet-rich fibrin; vitamin D3; root resorption

Outcome Measures

Primary Outcomes (1)

• - Assess the effect of using PRF and vitamin Dꝫ injections on root resorption and length and compare them by using CBCT.

  Cone beam computed tomography (CBCT) will be obtained before treatment and after canine retraction to evaluate the severity of root resorption associated with the two techniques.

  3 - 4 months

Study Arms (2)

Platelet-rich Fibrin

EXPERIMENTAL

A 20 ml blood sample will be drawn from the median cubital vein into a PRF tube. Centrifugation will be done at 700 rpm for 3 minutes and the liquid of PRF will be suctioned out using a separate syringe. PRF will be injected distal to the canine on the experimental side three times; at the beginning of canine retraction (T0), 1 month after the start of canine retraction (T1), and 2 months after the start of canine retraction (T2).

Other: Platelet-rich Fibrin

Vitamin D3

EXPERIMENTAL

Subjects will receive vitamin Dꝫ injection distal to the canine on the experimental side three times; at the beginning of canine retraction (T0), 1 month after the start of canine retraction (T1), and 2 months after the start of canine retraction (T2).

Other: Vitamin D3

Interventions

Platelet-rich Fibrin OTHER

Platelet-rich Fibrin will be injected distal to the canine on the experimental side

Platelet-rich Fibrin

Vitamin D3 OTHER

Vitamin D3 will be injected distal to the canine on the experimental side

Vitamin D3

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18- 40 years old.
• Angle Class I or Class II dental malocclusion that required bilateral maxillary first premolar extraction and upper canine retraction as a part of the treatment plan.
• Good to fair oral hygiene.
• Normal probing depth.

You may not qualify if:

• Active periodontal disease.
• Poor oral hygiene.
• Systemic diseases or medications that alter bone metabolism or tooth movement.
• Craniofacial anomalies

Sponsors & Collaborators

• Beni-Suef University: lead

Study Sites (1)

Faculty of Dentistry Beni Suef University

Banī Suwayf, Egypt

RECRUITING

Related Publications (16)

• Nakano T, Hotokezaka H, Hashimoto M, Sirisoontorn I, Arita K, Kurohama T, Darendeliler MA, Yoshida N. Effects of different types of tooth movement and force magnitudes on the amount of tooth movement and root resorption in rats. Angle Orthod. 2014 Nov;84(6):1079-85. doi: 10.2319/121913-929.1. Epub 2014 Apr 22.

  PMID: 24754797 BACKGROUND

• Kalra S, Gupta P, Tripathi T, Rai P. External apical root resorption in orthodontic patients: molecular and genetic basis. J Family Med Prim Care. 2020 Aug 25;9(8):3872-3882. doi: 10.4103/jfmpc.jfmpc_802_20. eCollection 2020 Aug.

  PMID: 33110782 BACKGROUND

• Dudic A, Giannopoulou C, Meda P, Montet X, Kiliaridis S. Orthodontically induced cervical root resorption in humans is associated with the amount of tooth movement. Eur J Orthod. 2017 Oct 1;39(5):534-540. doi: 10.1093/ejo/cjw087.

  PMID: 28339612 BACKGROUND

• Jiang RP, McDonald JP, Fu MK. Root resorption before and after orthodontic treatment: a clinical study of contributory factors. Eur J Orthod. 2010 Dec;32(6):693-7. doi: 10.1093/ejo/cjp165. Epub 2010 Mar 22.

  PMID: 20308200 BACKGROUND

• Gupta P, Bhagyalakshmi A, Avinash BS, Prashant A, Raghunath N. Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: An in-vivo study. Am J Orthod Dentofacial Orthop. 2022 Nov;162(5):735-743. doi: 10.1016/j.ajodo.2021.07.019. Epub 2022 Aug 23.

  PMID: 36008239 BACKGROUND

• Erdur EA, Karakasli K, Oncu E, Ozturk B, Hakki S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod. 2021 May 1;91(3):285-292. doi: 10.2319/060320-508.1.

  PMID: 33459765 BACKGROUND

• Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement : A randomized split-mouth-controlled trial. J Orofac Orthop. 2021 Jul;82(4):268-277. doi: 10.1007/s00056-020-00275-x. Epub 2021 Jan 22.

  PMID: 33481053 BACKGROUND

• Reyes Pacheco AA, Collins JR, Contreras N, Lantigua A, Pithon MM, Tanaka OM. Distalization rate of maxillary canines in an alveolus filled with leukocyte-platelet-rich fibrin in adults: A randomized controlled clinical split-mouth trial. Am J Orthod Dentofacial Orthop. 2020 Aug;158(2):182-191. doi: 10.1016/j.ajodo.2020.03.020. Epub 2020 Jun 24.

  PMID: 32591274 BACKGROUND

• Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021 Mar 2;21(1):92. doi: 10.1186/s12903-021-01456-9.

  PMID: 33653326 BACKGROUND

• Varughese ST, Shamanna PU, Goyal N, Thomas BS, Lakshmanan L, Pulikkottil VJ, Ahmed MG. Effect of Vitamin D on Canine Distalization and Alveolar Bone Density Using Multi-slice Spiral CT: A Randomized Controlled Trial. J Contemp Dent Pract. 2019 Dec 1;20(12):1430-1435.

  PMID: 32381845 BACKGROUND

• Al-Attar A, Abid M. The Effect of Vitamin D3 on the Alignment of Mandibular Anterior Teeth: A Randomized Controlled Clinical Trial. Int J Dent. 2022 Feb 14;2022:6555883. doi: 10.1155/2022/6555883. eCollection 2022.

  PMID: 35198025 BACKGROUND

• Khalaf RM, Almudhi AA. Effects of vitamin D deficiency on the rate of orthodontic tooth movement: An animal study. Saudi Dent J. 2022 Feb;34(2):129-135. doi: 10.1016/j.sdentj.2021.12.008. Epub 2021 Dec 23.

  PMID: 35241902 BACKGROUND

• Tehranchi A, Sadighnia A, Younessian F, Abdi AH, Shirvani A. Correlation of Vitamin D status and orthodontic-induced external apical root resorption. Dent Res J (Isfahan). 2017 Nov-Dec;14(6):403-411. doi: 10.4103/1735-3327.218565.

  PMID: 29238379 BACKGROUND

• Azizi F, Karami N, Golshah A, Imani MM, Safari-Faramani R. Effect of Serum Level of Vitamin D on External Apical Root Resorption in Maxillary Anterior Teeth in Patients under Fixed Orthodontic Treatment. Int J Dent. 2022 Sep 27;2022:7942998. doi: 10.1155/2022/7942998. eCollection 2022.

  PMID: 36203821 BACKGROUND

• Navya S, Prashantha GS, Sabrish S, Roshan MS, Mathew S. Evaluation of the effect of local administration of PRP vs vitamin D3 on the rate of orthodontic tooth movement and the associated external apical root resorption. J Oral Biol Craniofac Res. 2022 Nov-Dec;12(6):879-884. doi: 10.1016/j.jobcr.2022.09.011. Epub 2022 Oct 4.

  PMID: 36250145 BACKGROUND

• Lund H, Grondahl K, Hansen K, Grondahl HG. Apical root resorption during orthodontic treatment. A prospective study using cone beam CT. Angle Orthod. 2012 May;82(3):480-7. doi: 10.2319/061311-390.1. Epub 2011 Sep 16.

  PMID: 21919826 BACKGROUND

MeSH Terms

Conditions

Root Resorption

Interventions

Cholecalciferol

Condition Hierarchy (Ancestors)

Tooth Resorption; Tooth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Cholestenes; Cholestanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Sterols; Vitamin D; Secosteroids; Membrane Lipids; Lipids

Study Officials

• Rehab Khalil

  Faculty of Dentistry Beni Suef University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rehab Khalil

CONTACT

01005230669; rehababdelrazek@dent.bsu.edu.eg

Walid Salem

CONTACT

01032206673; dr.waledsalem@dent.bsu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Single-blinded limited to the outcome assessment
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Orthodontics

Model Details: split-mouth, prospective, single-center, single-blinded, two-arm randomized clinical trial with a 1:1 allocation ratio.

Study Record Dates

• First Submitted: December 27, 2023
• First Posted: January 10, 2024
• Study Start: May 11, 2023
• Primary Completion: March 1, 2024
• Study Completion: April 1, 2024
• Last Updated: January 11, 2024

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)