Correlation Between Root Resorption and Dentin Sialoprotein Upon Application of Different Orthodontic Forces.

NCT03644537 | Unknown

• 1 other identifier: CEBD-CU-2018-07-13
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

Since root resorption is a frequent consequence of orthodontic treatment, DSP are non-collagenous dentin-specific matrix proteins postulated to be involved in the mineralization of pre-dentin into dentin. Calculating the amount of DSP -Dentine Sialo Protein- produced upon root resorption might be an indicative biological marker for root resorption

Conditions

Root Resorption

Outcome Measures

Primary Outcomes (1)

• DSP (DentinSialoProtein )

  concentration of DSP is expected to be secreted into the gingival crevicular fluid upon root resorption

  with in 3 monthes from applied intrusion

Study Arms (3)

heavy force 100gm

OTHER

heavy intrusive force is to be applied on a first premolar on one side

Procedure: Orthodontic intrusion

medium force 25 gm

OTHER

medium intrusive force is to be applied on a first premolar on one side

Procedure: Orthodontic intrusion

light force 10 gm

OTHER

light intrusive force is to be applied on a first premolar on one side

Procedure: Orthodontic intrusion

Interventions

Orthodontic intrusion PROCEDURE

27 female patients coming to the Orthodontic department, Cairo University seeking orthodontic treatment, where their age ranges from 15 - 18 years, where their treatment plan include extraction of upper first premolars, and using the split-mouth technique, one side will be control group without application of force where the other side will receive intrusive mechanics for the same patient in the upper arch (one side will not receive any force and the same tooth on the other side of the arch will suffer intrusive mechanics, that's why named SPLIT MOUTH TECHNIQUE - as if the arch is split into two subjects, one control subject (tooth) and the other study subject (tooth) . According to the amount of force of the working side, the total number of patients will be divided into 3 groups. Each of 9 subjects, the first group where a light force will be applied (10 gm), the second group where moderate force will be applied (25gm), the third group where heavy force will be applied(100 gram).

heavy force 100gm; light force 10 gm; medium force 25 gm

Eligibility Criteria

• Age: 15 Years - 18 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Adolescent female patients age ranging from 15- 18 yrs, with the full set of the permanent dentition.
• No previous orthodontic treatment.
• Class I crowding or Class II malocclusion whose treatment requires extraction of first maxillary premolars.
• Adequate oral hygiene.

You may not qualify if:

• Systematic diseases.
• Bad Oral hygiene.
• Missing permanent teeth (except for third molars).
• Uncontrolled Pathological Conditions that may contra-indicate immediate orthodontic treatment (caries, gingivitis, periodontitis).

Sponsors & Collaborators

• Aya Ahmed Moursi El Faham: lead

Study Sites (1)

economic treatment center, Orthodontics Department, Cairo University

Cairo, Egypt

RECRUITING

MeSH Terms

Conditions

Root Resorption

Condition Hierarchy (Ancestors)

Tooth Resorption; Tooth Diseases; Stomatognathic Diseases

Central Study Contacts

Aya A El Faham, Master student

CONTACT

01099922902; aya.elfaham@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: July 13, 2018
• First Posted: August 23, 2018
• Study Start: October 7, 2017
• Primary Completion: April 1, 2019
• Study Completion: June 1, 2019
• Last Updated: August 23, 2018

Record last verified: 2018-08

Locations

EG (1)