Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans

NCT05344287 | Completed

• 1 other identifier: 2019-0318
• Study Type: observational
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.

Conditions

Cardiovascular Diseases; Hypertension; Diet, Healthy

Keywords

health disparity; endothelial function; hypertension; vegan diet; Black Americans; inflammation

Outcome Measures

Primary Outcomes (10)

• Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG)

  Day 1

• C-reactive protein

  Day 1

• Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline)

  Day 1

• Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline)

  Day 1

• Pulse wave velocity (carotid-to-femoral)

  Day 1

• Augmentation index (AIx@HR75)

  Day 1

• Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline)

  Day 2

• Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline)

  Day 2

• Peripheral blood pressure (systolic, diastolic, mean)

  Day 1

• Central blood pressure (systolic, diastolic, mean)

  Day 1

Study Arms (2)

Typical American Diet

African American individuals who self-report adhering to a typical American diet prior to enrolling in the study.

Other: Typical American Diet

Plant-Based Diet

African American individuals who self-report adhering to a plant-based diet prior to enrolling in the study.

Other: Plant-Based Diet

Interventions

Typical American Diet OTHER

Participants self-reported adherence to a typical American diet prior to enrolling in the study. This factor determined cross-sectional group allocation.

Typical American Diet

Plant-Based Diet OTHER

Participants self-reported adherence to a 100% plant-based diet prior to enrolling in the study. This factor determined cross-sectional group allocation.

Plant-Based Diet

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Community sample from the greater Dallas-Fort Worth Metroplex area.

You may qualify if:

• Self-identify as African American/Black
• Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet
• Age 18-40

You may not qualify if:

• History of smoking within 2 years or being a current smoker
• Taking vasoactive medications
• Having overt cardiovascular, metabolic, or neurological disease
• Pregnant individuals

Sponsors & Collaborators

• The University of Texas at Arlington: lead

Study Sites (1)

UT Arlington - Science and Engineering Innovation and Research Building

Arlington, Texas, 76019, United States

Location

Related Publications (1)

• Martin ZT, Olvera G, Villegas CA, Campbell JC, Akins JD, Brown KK, Brothers RM. The impact of a plant-based diet on indices of cardiovascular health in African Americans: a cross-sectional study. Appl Physiol Nutr Metab. 2022 Sep 1;47(9):903-914. doi: 10.1139/apnm-2022-0027. Epub 2022 May 5.

  PMID: 35512369 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

stored serum

MeSH Terms

Conditions

Cardiovascular Diseases; Hypertension; Inflammation

Interventions

Diet, Plant-Based

Condition Hierarchy (Ancestors)

Vascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Robert M Brothers, PhD

  The University of Texas at Arlington

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 12, 2022
• First Posted: April 25, 2022
• Study Start: July 12, 2019
• Primary Completion: January 13, 2020
• Study Completion: January 13, 2020
• Last Updated: May 5, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will share

Locations

US (1)