Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

NCT05341258 | Completed

• 1 other identifier: 3751
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured. Blood gas analysis is routinely performed in patients whom intubated in the intensive care unit and receiving mechanical ventilation support, and the patient's treatment is optimized according to the results of the examination. The patient's mechanical ventilation settings are regulated by analyzing the Partial Arterial Carbondioxide (paCO2) value in the patient's blood gas result. The difference between the paCO2 value in the blood gas and the End-tidal Carbondioxide (EtCO2) value measured in the mechanical ventilator is 3-5mmHg in normal healthy people, while this difference is seen more in critical care patients. In critically ill patients in the intensive care unit, there is a greater increase in the difference between paCO2 and ETCO2 in cases where mortality is high, such as global perfusion disorder, shock situations, and massive pulmonary embolism, etc. In this study, it was planned to investigate the use of the difference between the paCO2 value in the blood gas taken from the patient and the ETCO2 value measured in the mechanical ventilator to predict the mortality rate of the patient.

Conditions

Critical Illness; Ventilation Perfusion Mismatch; Shock; Pulmonary Embolism; Trauma; Copd

Outcome Measures

Primary Outcomes (1)

• Mortality

  Evaluation of correlation between PaCO2 and ETCO2 gradient difference and mortality in intubated critical care patients and mortality rates

  6 months

Secondary Outcomes (2)

• ICU Length of Stay

  6 months

• Ventilator Free Days

  6 months

Study Arms (1)

Critical Care Patients whom intubated last 24 hours

OTHER

Critical Care Patients whom intubated last 24 hours

Diagnostic Test: EtCO2; Diagnostic Test: PaCO2

Interventions

EtCO2 DIAGNOSTIC_TEST

EtCO2

Critical Care Patients whom intubated last 24 hours

PaCO2 DIAGNOSTIC_TEST

PaCO2

Critical Care Patients whom intubated last 24 hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Critical Care Patients intubated in last 24 hours.

You may not qualify if:

• Patients younger than 18 years old.

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

Study Sites (1)

Gaziosmanpasa Training Research Hospital

Istanbul, 34255, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Critical Illness; Shock; Pulmonary Embolism; Wounds and Injuries; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Lung Diseases, Obstructive; Chronic Disease

Study Officials

• Ulku Aygen Turkmen, Proffessor

  Director of Anesthesiology and Reanimation Department

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 17, 2022
• First Posted: April 22, 2022
• Study Start: January 1, 2022
• Primary Completion: August 1, 2022
• Study Completion: August 1, 2022
• Last Updated: August 24, 2022

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)