NCT05330650

Brief Summary

A prospective comparative randomized blinded study conducted in the obstetrics gynecology department of Ben Arous hospital over an eight-month period between November 2020 and June 2021. The aim of this study is to evaluate effectiveness of Triclosan coated suture use in obstetrical surgery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
318

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Nov 2020

Shorter than P25 for phase_4

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2020

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2021

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2021

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

March 21, 2022

Completed
25 days until next milestone

First Posted

Study publicly available on registry

April 15, 2022

Completed
Last Updated

April 15, 2022

Status Verified

April 1, 2022

Enrollment Period

7 months

First QC Date

March 21, 2022

Last Update Submit

April 8, 2022

Conditions

Keywords

Surgical Site Infectionscaesarean sectionhealthcare costs

Outcome Measures

Primary Outcomes (1)

  • Incidence of surgical site infection

    30 days

Secondary Outcomes (2)

  • Health care costs attributable to surgical site infection

    30 days

  • Wound healing time

    30 days

Study Arms (2)

Triclosan coated suture

ACTIVE COMPARATOR
Drug: Coated Vicryl+

Non coated suture

ACTIVE COMPARATOR
Drug: Vicryl

Interventions

We used coated suture for : hystetrotomy reparation / aponeurosis and skin closure.

Triclosan coated suture
VicrylDRUG

We used non coated suture for : hystetrotomy reparation / aponeurosis and skin closure.

Non coated suture

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Pregnant women with indicated cesarean delivery and who have signed a written consent.

You may not qualify if:

  • Cases with incomplete follow up
  • Breach of operative protocol

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Obstetrics and Gynecology Departement

Ben Arous, 2096, Tunisia

Location

Related Publications (1)

  • Mbarki W, Bettaieb H, Souayeh N, Laabidi I, Rouis H, Halouani S, Boufarghine R, Bouyahia M, Bouhmida R, Ouederni M, Ben Amor A, Chermiti A, Laamiri H, Lika A, Chaibi I, Oueslati H, Hsayaoui N, Mbarki C. Evaluation of Triclosan coated suture in obstetrical surgery: A prospective randomized controlled study (NCT05330650). PLoS One. 2022 Dec 15;17(12):e0278939. doi: 10.1371/journal.pone.0278939. eCollection 2022.

MeSH Terms

Conditions

InfectionsSurgical Wound Infection

Interventions

Polyglactin 910

Condition Hierarchy (Ancestors)

Wound InfectionPostoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PolyestersPolymersMacromolecular SubstancesBiomedical and Dental MaterialsManufactured MaterialsTechnology, Industry, and Agriculture

Study Officials

  • Chaouki Mbarki

    Ben Arous Hospital, Tunis, Tunisia

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant professor

Study Record Dates

First Submitted

March 21, 2022

First Posted

April 15, 2022

Study Start

November 1, 2020

Primary Completion

May 31, 2021

Study Completion

June 30, 2021

Last Updated

April 15, 2022

Record last verified: 2022-04

Data Sharing

IPD Sharing
Will not share

Locations