The Effect of Breaking Prolonged Sitting on Adipose Tissue and Metabolism
1 other identifier
interventional
11
0 countries
N/A
Brief Summary
The purpose of this project is to investigate the effect of breaking prolonged sitting on acute adipose tissue and metabolic responses.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jul 2014
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2016
CompletedFirst Submitted
Initial submission to the registry
February 9, 2016
CompletedFirst Posted
Study publicly available on registry
August 17, 2016
CompletedAugust 17, 2016
August 1, 2016
1.5 years
February 9, 2016
August 11, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Incremental area under curve (iAUC) for insulin
330 minutes
Secondary Outcomes (4)
Changes in gene expression in the adipose tissue
Before the 1st meal and 120 min after the 2nd meal (330 minutes).
Changes in insulin, glucose, TAG and NEFA in blood
330 minutes
Changes in serum Interleukin-6 (IL-6), leptin and adiponectin
330 minutes
Changes in Interleukin-6 (IL-6), leptin and adiponectin protein secretion from adipose tissue explants
Before the 1st meal and 120 min after the 2nd meal (330 minutes).
Study Arms (2)
Prolonged Sitting
ACTIVE COMPARATORParticipants sat on a chair during the trial.
Breaking Sitting
EXPERIMENTALParticipants walked regularly during the trial.
Interventions
After consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min.
After consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min.
Eligibility Criteria
You may qualify if:
- Male and post-menopausal females (post-menopausal diagnosis based on consecutive absence of menstrual cycles for \>12 months).
- Aged between 35 and 64 years
- Central overweight (waist circumference greater than 94 cm for males and 80 cm for females)
- Weight stable for more than 3 months (no change in weight +/- 3%)
- Non-smoker
- Able to walk comfortably on a treadmill
You may not qualify if:
- Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
- Waist circumference \< 94cm for male and \< 80cm for female
- Taking medications that may influence lipid or carbohydrate metabolism or immune system function
- Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Bathlead
- Ministry of Education, Taiwancollaborator
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD student
Study Record Dates
First Submitted
February 9, 2016
First Posted
August 17, 2016
Study Start
July 1, 2014
Primary Completion
January 1, 2016
Study Completion
January 1, 2016
Last Updated
August 17, 2016
Record last verified: 2016-08