NCT05244603

Brief Summary

Dysarthria and hearing loss are communication disorders that can substantially reduce intelligibility of speech and the addition of background noise adds a further challenge. This proposal utilizes an established signal processing technique, currently exploited for improved understanding of speech in noise for listeners with hearing loss, to investigate its potential application to overcome speech-in-noise difficulties for listeners understanding dysarthric speech. Successful completion of this project will demonstrate proof-of-concept for the application of this signal processing technique to dysarthric speech in noise, and inform the development of an R01 proposal to perform a large-scale evaluation of the technology, and clinically meaningful implications, in a broad range of disordered speech types and severities.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
435

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Dec 2021

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2021

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

February 4, 2022

Completed
13 days until next milestone

First Posted

Study publicly available on registry

February 17, 2022

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2023

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2023

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

March 26, 2025

Completed
Last Updated

March 26, 2025

Status Verified

March 1, 2025

Enrollment Period

2 years

First QC Date

February 4, 2022

Results QC Date

December 3, 2024

Last Update Submit

March 24, 2025

Conditions

Hearing Loss, SensorineuralDysarthria

Outcome Measures

Primary Outcomes (1)

  • Percent Correct Speech Intelligibility

    Percent of keywords correctly identified by the participant for the processed speech stimuli, listeners were presented with phrases containing several words and they reported back what they heard. The number of words corrected reported by each listener was counted and converted to a 'percent correct' score.

    One hour

Study Arms (2)

Normal Hearing

EXPERIMENTAL

Listeners with normal hearing

Behavioral: Ideal binary mask

Hearing Impaired

EXPERIMENTAL

Listeners with hearing loss

Behavioral: Ideal binary mask

Interventions

Ideal binary maskBEHAVIORAL

Speech in noise processed by ideal binary mask to reduce background noise

Hearing ImpairedNormal Hearing

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Native speakers of American English
  • No history of speech or language impairment
  • No significant prior contact with persons having neurogenic speech disorders
  • to 70 years of age
  • Auditory thresholds of 20 dB HL or better bilaterally at octave frequencies from 250-8000 Hz (if under 55 years of age)
  • Auditory thresholds of 25 dB HL or better bilaterally at octave frequencies from 250-4000 Hz (if over 55 years of age)
  • to 90 years of age

You may not qualify if:

  • Mild or profound hearing loss
  • Conductive or mixed hearing loss
  • Asymmetric hearing loss
  • Obvious concomitant cognitive or mental impairment
  • Unable to achieve upward of 20% words correct

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Utah State University

Logan, Utah, 43221, United States

Location

Related Publications (1)

  • Borrie SA, Yoho SE, Healy EW, Barrett TS. The Application of Time-Frequency Masking To Improve Intelligibility of Dysarthric Speech in Background Noise. J Speech Lang Hear Res. 2023 May 9;66(5):1853-1866. doi: 10.1044/2023_JSLHR-22-00558. Epub 2023 Mar 21.

    PMID: 36944186RESULT

MeSH Terms

Conditions

Hearing Loss, SensorineuralDysarthria

Condition Hierarchy (Ancestors)

Hearing LossHearing DisordersEar DiseasesOtorhinolaryngologic DiseasesSensation DisordersNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsArticulation DisordersSpeech DisordersLanguage DisordersCommunication DisordersNeurobehavioral Manifestations

Results Point of Contact

Title
Dr. Sarah Yoho Leopold
Organization
Utah State University
sarah.leopold@usu.edu
6145708258

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Primary Investigator

Study Record Dates

First Submitted

February 4, 2022

First Posted

February 17, 2022

Study Start

December 1, 2021

Primary Completion

December 1, 2023

Study Completion

December 30, 2023

Last Updated

March 26, 2025

Results First Posted

March 26, 2025

Record last verified: 2025-03

Data Sharing

IPD Sharing
Will not share

Locations

US(1)