Sleep Timing on Energy Intake and Energy Expenditure

NCT05096585 | Completed

• 1 other identifier: sleep timing 2016786
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

Studies in healthy young adults have shown that abnormal and undesirable physiological changes are a result of chronic sleep curtailment, with implications on inflammatory status, blood glucose regulation, circulating free fatty acids, and insulin sensitivity. Epidemiological studies suggest an increase in energy intake with shortened, sleep and this has been associated with weight gain. Interestingly most studies examining sleep restriction do not consider whether the restricted sleep is due to sleep delay or an advanced wake time. This study will investigate the change in physical activity or food intake during a period of sleep restriction. To date only one study has addressed this question but they only examined one study night and followed their subjects for only 24 hr. The objective of the proposed project is to examine the effects of shortened sleep on potential changes in physical activity and energy intake. The investigators hypothesize that after several nights of short sleep that different strategies are employed to remain awake and these strategies will also vary whether bed time was delayed or wake time was advanced. Aim 1: To examine the effects of sleep timing on energy intake and expenditure during periods of sleep restriction

Conditions

Obesity

Keywords

sleep restriction; physical activity; dietary intake; insulin resistance

Outcome Measures

Primary Outcomes (4)

• physical activity

  physical activity (percent time in sedentary, light, moderate and vigorous PA)

  24 hours

• dietary intake

  macronutrient content (percent carbohydrate, fat and protein intake

  24 hours

• physical activity

  Step count (steps/day)

  24 hours

• dietary intake

  energy intake (kcals)

  24 hour

Study Arms (3)

normal sleep

PLACEBO COMPARATOR

Subjects will go to sleep at their normal bedtime and normal sleep duration (7-9 hr)

Behavioral: Delayed bedtime sleep restriction; Behavioral: Early wake sleep restriction

delayed bedtime sleep restriction

EXPERIMENTAL

Subjects will go to sleep at 2 hr later than their normal bedtime

Behavioral: Delayed bedtime sleep restriction; Behavioral: Early wake sleep restriction

early waking sleep restriction

EXPERIMENTAL

Subjects will wake up 2 hr earlier than their normal wake time

Behavioral: Delayed bedtime sleep restriction; Behavioral: Early wake sleep restriction

Interventions

Delayed bedtime sleep restriction BEHAVIORAL

bedtime 2 hr later than their normal bedtime

delayed bedtime sleep restriction; early waking sleep restriction; normal sleep

Early wake sleep restriction BEHAVIORAL

wake time 2 hr earlier than their normal wake time

delayed bedtime sleep restriction; early waking sleep restriction; normal sleep

Eligibility Criteria

• Age: 21 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Overweight and obese men and women 21-45 years of age BMI of \<40 kg/m2 normally active (\>5000 steps per day) sleep: 7-9 hours per night

You may not qualify if:

• type 1 diabetes cardiovascular disease uncontrolled hypertension smoker pregnant recent changes in hormonal birth control night shift workers take regular daytime naps operate heavy equipment Sleep less than 7 hour/night

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Misouri

Columbia, Missouri, 65211, United States

Location

MeSH Terms

Conditions

Obesity; Motor Activity; Insulin Resistance

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Officials

• Jill Kanaley, PhD

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Model Details: All subjects will complete 3 study conditions with a minimum of one week between each condition.

Study Record Dates

• First Submitted: October 14, 2021
• First Posted: October 27, 2021
• Study Start: August 1, 2021
• Primary Completion: December 1, 2022
• Study Completion: December 1, 2022
• Last Updated: March 10, 2023

Record last verified: 2023-03

Locations

US (1)