Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys

NCT05022992 | Unknown

• 1 other identifier: 2020-03179
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention. Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.

Conditions

Hormones; Cytokines

Outcome Measures

Primary Outcomes (8)

• Growth Hormone Baseline

  Blood Concentration of Growth Hormone

  Baseline testing before the exercise intervention (Pre values)

• Change from Baseline Growth Hormone Post exercise

  Blood Concentration of Growth Hormone

  Right after the completion of the exercise intervention (Post values)

• Change from Baseline Growth Hormone 15 minutes post exercise

  Blood Concentration of Growth Hormone

  15 minutes after the completion of the exercise intervention (Post-15 values)

• Change from Baseline Growth Hormone 30 minutes post exercise

  Blood Concentration of Growth Hormone

  30 minutes after the completion of the exercise intervention (Post-30 values)

• Insulin-like Growth Factor-1 Baseline

  Blood concentration of Insulin-like Growth Factor-1

  Baseline testing before the exercise intervention (Pre values)

• Change from Baseline Insulin-like Growth Factor-1 Post exercise

  Blood concentration of Insulin-like Growth Factor-1

  Right after the completion of the exercise intervention (Post values)

• Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise

  Blood concentration of Insulin-like Growth Factor-1

  15 minutes after the completion of the exercise intervention (Post-15 values)

• Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise

  Blood concentration of Insulin-like Growth Factor-1

  30 minutes after the completion of the exercise intervention (Post-30 values)

Secondary Outcomes (24)

• Cortisol Baseline

  Baseline testing before the exercise intervention (Pre values)

• Change from Baseline Cortisol Post exercise

  Right after the completion of the exercise intervention (Post values)

• Change from Baseline Cortisol 15 minutes Post exercise

  15 minutes after the completion of the exercise intervention (Post-15 values)

• Change from Baseline Cortisol 30 minutes Post exercise

  30 minutes after the completion of the exercise intervention (Post-30 values)

• Testosterone Baseline

  Baseline testing before the exercise intervention (Pre values)

Study Arms (2)

Resistance Training Session

EXPERIMENTAL

Resistance training. Heavy resistance training. 10 reps x 3 set of upper- and lower-body resistance exercises

Other: Resistance Training

Control

NO INTERVENTION

Control activity. None-exercising. 30 min of rest

Interventions

Resistance Training OTHER

Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.

Resistance Training Session

Eligibility Criteria

• Age: 9 Years - 17 Years
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Healthy boys (n=40)
• Physically active, defined as a minimum of 2 years experience in a sports club
• Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
• No previous experience of structured resistance training

You may not qualify if:

• Chronic diseases that affect full participation
• Injuries that limit full participation

Sponsors & Collaborators

• Umeå University: lead

Study Sites (1)

Umeå Movement and Exercise Laboratory, Umeå University

Umeå, Västerbotten County, 901 87, Sweden

Location

Related Publications (1)

• Jansson D, Lundberg E, Rullander AC, Domellof M, Lindberg AS, Andersson H, Theos A. Hormonal and inflammatory responses in prepubertal vs. pubertal male children following an acute free-weight resistance training session. Eur J Appl Physiol. 2025 Feb;125(2):381-392. doi: 10.1007/s00421-024-05603-2. Epub 2024 Sep 11.

  PMID: 39259397 DERIVED

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Apostolos Theos, PhD

  Umeå University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Apostolos Theos, PhD

CONTACT

+46702811565; apostolos.theos@umu.se

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: June 11, 2021
• First Posted: August 26, 2021
• Study Start: September 1, 2021
• Primary Completion: December 1, 2021
• Study Completion: March 1, 2022
• Last Updated: August 26, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)